scholarly journals Endometrial intraepithelial neoplasia with secretory differentiation: diagnostic features and underlying mechanisms

2013 ◽  
Vol 26 (6) ◽  
pp. 868-873 ◽  
Author(s):  
Carlos E Parra-Herran ◽  
Nicolas M Monte ◽  
George L Mutter
Keyword(s):  
Intraepithelial Neoplasia ◽  
Diagnostic Features ◽  
Endometrial Intraepithelial Neoplasia ◽  
Underlying Mechanisms ◽  
Secretory Differentiation

Endometrial hyperplasia (Clinical lecture)

2016 ◽  
pp. 10-18 ◽  
Author(s):  
I.B. Vovk ◽  
◽  
N.Е. Gorban ◽  
O.Ju. Borysiuk ◽  
◽  
...  
Keyword(s):  
Key Words ◽  
Hormonal Therapy ◽  
Endometrial Hyperplasia ◽  
Intraepithelial Neoplasia ◽  
Diagnosis And Treatment ◽  
Pathogenetic Mechanisms ◽  
Endometrial Intraepithelial Neoplasia ◽  
Mechanisms Of Development ◽  
Clinical Lecture

In clinical lecture presents modern views of endometrial hyperplasia in terms of practitioner gynecologist. The problems of classification, pathogenetic mechanisms of development of endometrial hyperplasia. Particular attention is paid to modern approaches to diagnosis and treatment of endometrial hyperplasia. Key words: hyperplasia, endometrium, classification, endometrial hyperplasia, endometrial intraepithelial neoplasia, hormonal therapy.

scholarly journals Molecular Classification to Prognosticate Response in Medically Managed Endometrial Cancers and Endometrial Intraepithelial Neoplasia

Cancers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2847
Author(s):  
Allison M. Puechl ◽  
Daniel Spinosa ◽  
Andrew Berchuck ◽  
Angeles Alvarez Secord ◽  
Kerry E. Drury ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Single Gene ◽  
Intraepithelial Neoplasia ◽  
Molecular Classification ◽  
Definitive Treatment ◽  
Time To Progression ◽  
Endometrial Intraepithelial Neoplasia ◽  
Definitive Therapy ◽  
Patients At Risk ◽  
Endometrial Cancers

Background: The aim of this study was to evaluate whether molecular classification prognosticates treatment response in women with endometrial cancers and endometrial intraepithelial neoplasia (EIN) treated with levonorgestrel intrauterine system (LNG-IUS). Methods: Patients treated with LNG-IUS for endometrial cancer or EIN from 2013 to 2018 were evaluated. Using immunohistochemistry and single gene sequencing of POLE, patients were classified into four groups as per the Proactive Molecular Risk Classifier for Endometrial cancer (ProMisE): POLE-mutated, mismatch repair-deficient (MMRd), p53 wild type (p53wt), and p53-abnormal (p53abn). Groups were assessed relative to the primary outcome of progression or receipt of definitive treatment. Results: Fifty-eight subjects with endometrioid endometrial cancer or EIN treated with LNG-IUS were included. Of these, 22 subjects (37.9%) had endometrial cancer and 36 subjects (62.1%) had EIN. Per the ProMisE algorithm, 44 patients (75.9%) were classified as p53wt, 6 (10.3%) as MMRd, 4 (6.9%) as p53abn, and 4 (6.9%) as POLE-mutated. Of the 58 patients, 11 (19.0%) progressed or opted for definitive therapy. Median time to progression or definitive therapy was 7.5 months, with p53abn tumors having the shortest time to progression or definitive therapy. Conclusions: Molecular classification of endometrial cancer and EIN prior to management with LNG-IUS is feasible and may predict patients at risk of progression.

The malignant potential of endometrial polyps can be determined by incorporating the Endometrial Intraepithelial Neoplasia (EIN) classification

2014 ◽  
Vol 133 ◽  
pp. 180-181
Author(s):  
Y. Naaman ◽  
S. Perlman ◽  
J. Diment ◽  
N. Oustinov ◽  
E. Vaisbuch ◽  
...  
Keyword(s):  
Intraepithelial Neoplasia ◽  
Malignant Potential ◽  
Endometrial Polyps ◽  
Endometrial Intraepithelial Neoplasia

Ovarian preservation in low-grade endometrial cancer and endometrial intraepithelial neoplasia: outcomes and long-term health sequelae

2021 ◽  
Vol 162 ◽  
pp. S225
Author(s):  
Jennifer Hagen ◽  
Annika Deitermann ◽  
Annelise Wilhite ◽  
Britt Erickson
Keyword(s):  
Endometrial Cancer ◽  
Intraepithelial Neoplasia ◽  
Low Grade ◽  
Ovarian Preservation ◽  
Endometrial Intraepithelial Neoplasia

Innovative Protocol of ART in Women with LNG-Ius for Fertility-Sparing Treatment of Endometrial Intraepithelial Neoplasia

2021 ◽  
Vol 28 (11) ◽  
pp. S44
Author(s):  
A. Gallo ◽  
R. Vallone ◽  
C. Alviggi ◽  
I. Strina ◽  
G. Saccone ◽  
...  
Keyword(s):  
Intraepithelial Neoplasia ◽  
Fertility Sparing ◽  
Endometrial Intraepithelial Neoplasia

Benign Endometrial Hyperplasia Sequence and Endometrial Intraepithelial Neoplasia

2007 ◽  
Vol 26 (2) ◽  
pp. 103-114 ◽  
Author(s):  
George L. Mutter ◽  
Richard J. Zaino ◽  
Jan P.A. Baak ◽  
Rex C. Bentley ◽  
Stanley J. Robboy
Keyword(s):  
Endometrial Hyperplasia ◽  
Intraepithelial Neoplasia ◽  
Endometrial Intraepithelial Neoplasia

scholarly journals Access to fertility-sparing treatment of endometrial intraepithelial neoplasia: reproductive outcomes and patient satisfaction

2019 ◽  
Vol 112 (3) ◽  
pp. e115
Author(s):  
Matthew Shear ◽  
Alice Kennedy ◽  
Hannah Stack-Dunnbier ◽  
Emily A. Seidler ◽  
Michele Hacker ◽  
...  
Keyword(s):  
Patient Satisfaction ◽  
Intraepithelial Neoplasia ◽  
Reproductive Outcomes ◽  
Fertility Sparing ◽  
Endometrial Intraepithelial Neoplasia

Endometrial Intraepithelial Neoplasia Terminology in Practice

2012 ◽  
Vol 31 (2) ◽  
pp. 168-173 ◽  
Author(s):  
Sarah E. Kane ◽  
Jonathan L. Hecht
Keyword(s):  
Intraepithelial Neoplasia ◽  
Endometrial Intraepithelial Neoplasia
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