scholarly journals In vivo imaging of translocator protein, a marker of activated microglia, in alcohol dependence

2017 ◽  
Vol 22 (12) ◽  
pp. 1759-1766 ◽  
Author(s):  
A T Hillmer ◽  
C M Sandiego ◽  
J Hannestad ◽  
G A Angarita ◽  
A Kumar ◽  
...  
Keyword(s):  
Alcohol Dependence ◽  
In Vivo Imaging ◽  
Protein A ◽  
Translocator Protein ◽  
Activated Microglia

scholarly journals In vivo imaging of activated microglia in a mouse model of focal cerebral ischemia by two-photon microscopy

2015 ◽  
Vol 6 (9) ◽  
pp. 3303 ◽  
Author(s):  
Seoyeon Bok ◽  
Taejun Wang ◽  
Chan-Ju Lee ◽  
Seong-Uk Jeon ◽  
Young-Eun Kim ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Mouse Model ◽  
In Vivo Imaging ◽  
Focal Cerebral Ischemia ◽  
Activated Microglia ◽  
Two Photon Microscopy ◽  
Two Photon

In vivo imaging of neuroinflammation in the rodent brain with [11C]SSR180575, a novel indoleacetamide radioligand of the translocator protein (18 kDa)

2010 ◽  
Vol 38 (3) ◽  
pp. 509-514 ◽  
Author(s):  
Fabien Chauveau ◽  
Hervé Boutin ◽  
Nadja Van Camp ◽  
Cyrille Thominiaux ◽  
Philippe Hantraye ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Translocator Protein ◽  
Rodent Brain ◽  
Translocator Protein 18 Kda

scholarly journals TSPO PET Imaging: From Microglial Activation to Peripheral Sterile Inflammatory Diseases?

2017 ◽  
Vol 2017 ◽  
pp. 1-17 ◽  
Author(s):  
Bérenger Largeau ◽  
Anne-Claire Dupont ◽  
Denis Guilloteau ◽  
Maria-João Santiago-Ribeiro ◽  
Nicolas Arlicot
Keyword(s):  
Pet Imaging ◽  
Inflammatory Diseases ◽  
Protein A ◽  
Translocator Protein ◽  
Brain Diseases ◽  
Disease Heterogeneity ◽  
Peripheral Tissues ◽  
Positron Emission ◽  
Potential Biomarker

Peripheral sterile inflammatory diseases (PSIDs) are a heterogeneous group of disorders that gathers several chronic insults involving the cardiovascular, respiratory, gastrointestinal, or musculoskeletal system and wherein inflammation is the cornerstone of the pathophysiology. In PSID, timely characterization and localization of inflammatoryfociare crucial for an adequate care for patients. In brain diseases,in vivopositron emission tomography (PET) exploration of inflammation has matured over the last 20 years, through the development of radiopharmaceuticals targeting the translocator protein-18 kDa (TSPO) as molecular biomarkers of activated microglia. Recently, TSPO has been introduced as a possible molecular target for PSIDs PET imaging, making this protein a potential biomarker to address disease heterogeneity, to assist in patient stratification, and to contribute to predicting treatment response. In this review, we summarized the major research advances recently made in the field of TSPO PET imaging in PSIDs. Promising preliminary results have been reported in bowel, cardiovascular, and rheumatic inflammatory diseases, consolidated by preclinical studies. Limitations of TSPO PET imaging in PSIDs, regarding both its large expression in healthy peripheral tissues, unlike in central nervous system, and the production of peripheral radiolabeled metabolites, are also discussed, regarding their possible consequences on TSPO PET signal’s quantification.

scholarly journals Cerebrovascular and microglial states are not altered by functional neuroinflammatory gene variant

2016 ◽  
Vol 36 (4) ◽  
pp. 819-830 ◽  
Author(s):  
Daniel Felsky ◽  
Philip L De Jager ◽  
Julie A Schneider ◽  
Konstantinos Arfanakis ◽  
Debra A Fleischman ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Microglial Activation ◽  
Protein A ◽  
Translocator Protein ◽  
Postmortem Brain ◽  
Amyloid Angiopathy ◽  
Religious Orders ◽  
Binding Characteristics

The translocator protein, a microglial-expressed marker of neuroinflammation, has been implicated in Alzheimer’s disease, which is characterized by alterations in vascular and inflammatory states. A TSPO variant, rs6971, determines binding affinity of exogenous radioligands in vivo; however, the effect of these altered binding characteristics on inflammatory and cerebrovascular biomarkers has not been assessed. In 2345 living subjects (Alzheimer’s Disease Neuroimaging Initiative, n = 1330) and postmortem brain samples (Religious Orders Study and Memory and Aging Project, n = 1015), we analyzed effects of rs6971 on white matter hyperintensisites, cerebral infarcts, circulating inflammatory biomarkers, amyloid angiopathy, and microglial activation. We found that rs6971 does not alter translocator protein in a way that impacts cerebrovascular and inflammatory states known to be affected in dementia.

scholarly journals The translocator protein ligand [18F]DPA-714 images glioma and activated microglia in vivo

2012 ◽  
Vol 39 (5) ◽  
pp. 811-823 ◽  
Author(s):  
Alexandra Winkeler ◽  
Raphael Boisgard ◽  
Ali R. Awde ◽  
Albertine Dubois ◽  
Benoit Thézé ◽  
...  
Keyword(s):  
Translocator Protein ◽  
Activated Microglia

scholarly journals In Vivo Imaging of Translocator Protein in Long-term Cannabis Users

2019 ◽  
Vol 76 (12) ◽  
pp. 1305 ◽  
Author(s):  
Tania Da Silva ◽  
Sina Hafizi ◽  
Jeremy J. Watts ◽  
Cynthia Shannon Weickert ◽  
Jeffrey H. Meyer ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Translocator Protein

In vivo imaging of the 18-kDa translocator protein (TSPO) with [18F]FEDAA1106 and PET does not show increased binding in Alzheimer’s disease patients

2013 ◽  
Vol 40 (6) ◽  
pp. 921-931 ◽  
Author(s):  
Andrea Varrone ◽  
Patrik Mattsson ◽  
Anton Forsberg ◽  
Akihiro Takano ◽  
Sangram Nag ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
In Vivo Imaging ◽  
Translocator Protein

In vivo imaging of activated microglia using [11 C]PK11195 and positron emission tomography in patients after ischemic stroke

Neuroreport ◽  
2000 ◽  
Vol 11 (13) ◽  
pp. 2957-2960 ◽  
Author(s):  
Alexander Gerhard ◽  
Bernd Neumaier ◽  
Ercan Elitok ◽  
Gerhard Glatting ◽  
Vincent Ries ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Ischemic Stroke ◽  
In Vivo Imaging ◽  
Emission Tomography ◽  
Activated Microglia ◽  
Positron Emission
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