scholarly journals Sex-specific timing of meiotic initiation is regulated by Cyp26b1 independent of retinoic acid signalling

2011 ◽  
Vol 2 (1) ◽  
Author(s):  
Sandeep Kumar ◽  
Christina Chatzi ◽  
Thomas Brade ◽  
Thomas J. Cunningham ◽  
Xianling Zhao ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Retinoic Acid Signalling ◽  
Meiotic Initiation ◽  
Specific Timing

scholarly journals Cyp26b1 regulates sex-specific timing of meiotic initiation independent of retinoic acid

2011 ◽  
Vol 356 (1) ◽  
pp. 193
Author(s):  
Sandeep Kumar ◽  
Christina Chatzi ◽  
Thomas Brade ◽  
Thomas Cunningham ◽  
Xianling Zhao ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Meiotic Initiation ◽  
Specific Timing

scholarly journals Retinoic acid regulates sex-specific timing of meiotic initiation in mice

2006 ◽  
Vol 103 (8) ◽  
pp. 2474-2479 ◽  
Author(s):  
J. Koubova ◽  
D. B. Menke ◽  
Q. Zhou ◽  
B. Capel ◽  
M. D. Griswold ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Meiotic Initiation ◽  
Specific Timing

Genesis and prevention of spinal neural tube defects in the curly tail mutant mouse: involvement of retinoic acid and its nuclear receptors RAR-beta and RAR-gamma

Development ◽  
1995 ◽  
Vol 121 (3) ◽  
pp. 681-691
Author(s):  
W.H. Chen ◽  
G.M. Morriss-Kay ◽  
A.J. Copp
Keyword(s):  
Retinoic Acid ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
In Situ Hybridisation ◽  
Tail Bud ◽  
Retinoic Acid Signalling ◽  
All Trans Retinoic Acid ◽  
Posterior Neuropore ◽  
Computerised Image Analysis ◽  
Curly Tail

A role for all-trans-retinoic acid in spinal neurulation is suggested by: (1) the reciprocal domains of expression of the retinoic acid receptors RAR-beta and RAR-gamma in the region of the closed neural tube and open posterior neuropore, respectively, and (2) the preventive effect of maternally administered retinoic acid (5 mg/kg) on spinal neural tube defects in curly tail (ct/ct) mice. Using in situ hybridisation and computerised image analysis we show here that in ct/ct embryos, RAR-beta transcripts are deficient in the hindgut endoderm, a tissue whose proliferation rate is abnormal in the ct mutant, and RAR-gamma transcripts are deficient in the tail bud and posterior neuropore region. The degree of deficiency of RAR-gamma transcripts is correlated with the severity of delay of posterior neuropore closure. As early as 2 hours following RA treatment at 10 days 8 hours post coitum, i.e. well before any morphogenetic effects are detectable, RAR-beta expression is specifically upregulated in the hindgut endoderm, and the abnormal expression pattern of RAR-gamma is also altered. These results suggest that the spinal neural tube defects which characterise the curly tail phenotype may be due to interaction between the ct gene product and one or more aspects of the retinoic acid signalling pathway.

LSC - 2021 - Investigating the role of vitamin A intake and retinoic acid signalling in lung homeostasis and repair-A multidisciplinary approach

2021 ◽  
Author(s):  
Mongey Róisín ◽  
Sally Yunsun Kim ◽  
Diana Van Der Plaat ◽  
Cosetta Minelli ◽  
Charlotte Dean ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Vitamin A ◽  
Multidisciplinary Approach ◽  
Retinoic Acid Signalling

scholarly journals Bmpr1bb is a novel gene involved in retinoic acid induced patterning of the zebrafish hindbrain

Eureka ◽  
2010 ◽  
Vol 1 (1) ◽  
pp. 11-19
Author(s):  
Braden Teitge
Keyword(s):  
Retinoic Acid ◽  
Bone Morphogenetic Proteins ◽  
Critical Role ◽  
Retinoic Acid Treatment ◽  
Teratogenic Effects ◽  
Downstream Target ◽  
Retinoic Acid Signalling ◽  
Uncharacterized Gene ◽  
Vitamin A Derivative

Retinoic acid signalling plays a critical role during zebrafish development.  The teratogenic effects of retinoic acid have been demonstrated by embryonic deformation resulting from insufficient or excessive levels of this vitamin A derivative.  During embryogenesis, bone morphogenetic proteins are closely linked to the physiological interpretation of RA gradients, particularly in the hindbrain.  We describe an uncharacterized gene, Bmpr1bb, as being significantly downregulated in response to retinoic acid treatment.  In situ expression demonstrates that Bmpr1bb is expressed ubiquitously at 10hpf, and is slowly downregulated until 48hpf where the expression is concentrated in the hindbrain.  We propose that Bmpr1bb is a downstream target of RA signalling, strongly downregulated during embryogenesis and specified to a specific region of the hindbrain.

Retinoic acid and androgen influence germ cells development and meiotic initiation in juvenile orange-spotted grouper, Epinephelus coioides

2020 ◽  
Vol 289 ◽  
pp. 113379
Author(s):  
Cheng Peng ◽  
Qing Wang ◽  
Jiaxing Chen ◽  
Huirong Yang ◽  
Wenrui Zhang ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Germ Cells ◽  
Epinephelus Coioides ◽  
Meiotic Initiation

scholarly journals Retinoic acid-stimulated ERK1/2 pathway regulates meiotic initiation in cultured fetal germ cells

PLoS ONE ◽  
2019 ◽  
Vol 14 (11) ◽  
pp. e0224628 ◽  
Author(s):  
Sung-Min Kim ◽  
Toshifumi Yokoyama ◽  
Dylan Ng ◽  
Ferhat Ulu ◽  
Yukiko Yamazaki
Keyword(s):  
Retinoic Acid ◽  
Germ Cells ◽  
Meiotic Initiation

scholarly journals Retinoic acid signalling during development

Development ◽  
2012 ◽  
Vol 139 (5) ◽  
pp. 843-858 ◽  
Author(s):  
M. Rhinn ◽  
P. Dolle
Keyword(s):  
Retinoic Acid ◽  
Retinoic Acid Signalling
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