In vivo amplification of the androgen receptor gene and progression of human prostate cancer

1995 ◽  
Vol 9 (4) ◽  
pp. 401-406 ◽  
Author(s):  
Tapio Visakorpi ◽  
Eija Hyytinen ◽  
Pasi Koivisto ◽  
Minna Tanner ◽  
Riitta Keinänen ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Receptor Gene ◽  
Androgen Receptor Gene ◽  
Human Prostate ◽  
Human Prostate Cancer

scholarly journals Androgen receptor gene mutations in human prostate cancer.

1992 ◽  
Vol 89 (14) ◽  
pp. 6319-6323 ◽  
Author(s):  
J. R. Newmark ◽  
D. O. Hardy ◽  
D. C. Tonb ◽  
B. S. Carter ◽  
J. I. Epstein ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Receptor Gene ◽  
Gene Mutations ◽  
Androgen Receptor Gene ◽  
Human Prostate ◽  
Human Prostate Cancer

Androgen receptor gene mutations in human prostate cancer

1993 ◽  
Vol 46 (6) ◽  
pp. 759-765 ◽  
Author(s):  
Hiroyoshi Suzuki ◽  
Naohide Sato ◽  
Yoshio Watabe ◽  
Motoyuki Masai ◽  
Susumu Seino ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Receptor Gene ◽  
Gene Mutations ◽  
Androgen Receptor Gene ◽  
Human Prostate ◽  
Human Prostate Cancer

scholarly journals Focal amplification of the androgen receptor gene in hormone-naive human prostate cancer

2014 ◽  
Vol 110 (6) ◽  
pp. 1655-1662 ◽  
Author(s):  
S Merson ◽  
◽  
Z H Yang ◽  
D Brewer ◽  
D Olmos ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Receptor Gene ◽  
Androgen Receptor Gene ◽  
Human Prostate ◽  
Human Prostate Cancer

scholarly journals Genetic Alterations of Androgen Receptor Gene in Japanese Human Prostate Cancer

1997 ◽  
Vol 27 (6) ◽  
pp. 389-393 ◽  
Author(s):  
M. Watanabe ◽  
T. Ushijima ◽  
T. Shiraishi ◽  
R. Yatani ◽  
J. Shimazaki ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Receptor Gene ◽  
Genetic Alterations ◽  
Androgen Receptor Gene ◽  
Human Prostate ◽  
Human Prostate Cancer

Microsatellite Mutation (Cag24→18) in the Androgen Receptor Gene in Human Prostate Cancer

1994 ◽  
Vol 198 (1) ◽  
pp. 74-80 ◽  
Author(s):  
M.P. Schoenberg ◽  
J.M. Hakimi ◽  
S.P. Wang ◽  
G.S. Bova ◽  
J.I. Epstein ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Receptor Gene ◽  
Androgen Receptor Gene ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Microsatellite Mutation

scholarly journals GREB1 amplifies androgen receptor output in human prostate cancer and contributes to antiandrogen resistance

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Eugine Lee ◽  
John Wongvipat ◽  
Danielle Choi ◽  
Ping Wang ◽  
Young Sun Lee ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Target Gene ◽  
Prostate Cancer Cell ◽  
Human Prostate ◽  
Genomic Alteration ◽  
Human Prostate Cancer ◽  
Genomic Amplification ◽  
Human Prostate Cancer Cell

Genomic amplification of the androgen receptor (AR) is an established mechanism of antiandrogen resistance in prostate cancer. Here, we show that the magnitude of AR signaling output, independent of AR genomic alteration or expression level, also contributes to antiandrogen resistance, through upregulation of the coactivator GREB1. We demonstrate 100-fold heterogeneity in AR output within human prostate cancer cell lines and show that cells with high AR output have reduced sensitivity to enzalutamide. Through transcriptomic and shRNA knockdown studies, together with analysis of clinical datasets, we identify GREB1 as a gene responsible for high AR output. We show that GREB1 is an AR target gene that amplifies AR output by enhancing AR DNA binding and promoting EP300 recruitment. GREB1 knockdown in high AR output cells restores enzalutamide sensitivity in vivo. Thus, GREB1 is a candidate driver of enzalutamide resistance through a novel feed forward mechanism.

Lipid nanoparticle siRNA systems for silencing the androgen receptor in human prostate cancer in vivo

2012 ◽  
Vol 131 (5) ◽  
pp. E781-E790 ◽  
Author(s):  
Justin B. Lee ◽  
Kaixin Zhang ◽  
Yuen Yi C. Tam ◽  
Ying K. Tam ◽  
Nathan M. Belliveau ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Lipid Nanoparticle
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