DNA cleavage assay for the identification of topoisomerase I inhibitors

2008 ◽  
Vol 3 (11) ◽  
pp. 1736-1750 ◽  
Author(s):  
Thomas S Dexheimer ◽  
Yves Pommier
Keyword(s):  
Dna Cleavage ◽  
Topoisomerase I ◽  
Topoisomerase I Inhibitors ◽  
Cleavage Assay

Synthesis and Biological Evaluation of 1,5-Naphthyridines as Topoisomerase I Inhibitors. A New Family of Antiproliferative Agents

2015 ◽  
Vol 14 (23) ◽  
pp. 2722-2728 ◽  
Author(s):  
Concepcion Alonso ◽  
Maria Fuertes ◽  
Maria Gonzalez ◽  
Alicia Rodriguez-Gascon ◽  
Gloria Rubiales ◽  
...  
Keyword(s):  
Topoisomerase I ◽  
Biological Evaluation ◽  
Antiproliferative Agents ◽  
Topoisomerase I Inhibitors ◽  
New Family ◽  
Synthesis And Biological Evaluation

Investigation of Isoindolo[2,1-a]quinoxaline-6-imines as Topoisomerase I Inhibitors with Molecular Modeling Methods

2017 ◽  
Vol 13 (3) ◽  
Author(s):  
Balazs Balogh ◽  
Anna Carbone ◽  
Virginia Spanò ◽  
Alessandra Montalbano ◽  
Paola Barraja ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Topoisomerase I ◽  
Modeling Methods ◽  
Topoisomerase I Inhibitors

Radiation lethality enhancement with 9-aminocamptothecin: Comparison to other topoisomerase I inhibitors

1996 ◽  
Vol 36 (2) ◽  
pp. 369-376 ◽  
Author(s):  
John P. Lamond ◽  
Meizhi Wang ◽  
Timothy J. Kinsella ◽  
David A. Boothman
Keyword(s):  
Topoisomerase I ◽  
Topoisomerase I Inhibitors

scholarly journals DNA sequence selectivity of human topoisomerase I-mediated DNA cleavage induced by camptothecin

2009 ◽  
Vol 18 (6) ◽  
pp. 1326-1331
Author(s):  
Chandanamali Punchihewa ◽  
Megan Carver ◽  
Danzhou Yang
Keyword(s):  
Dna Sequence ◽  
Dna Cleavage ◽  
Topoisomerase I ◽  
Sequence Selectivity
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