Caspase 2 in apoptosis, the DNA damage response and tumour suppression: enigma no more?

2010 ◽  
Author(s):  
Sharad Kumar
Keyword(s):  
Dna Damage ◽  
Dna Damage Response ◽  
Tumour Suppression ◽  
Damage Response ◽  
Caspase 2

scholarly journals Erratum: Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability

2012 ◽  
Vol 19 (8) ◽  
pp. 1411-1411 ◽  
Author(s):  
L Dorstyn ◽  
J Puccini ◽  
C H Wilson ◽  
S Shalini ◽  
M Nicola ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Damage Response ◽  
Genetic Instability ◽  
Damage Response ◽  
Caspase 2

scholarly journals Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability

2012 ◽  
Vol 19 (8) ◽  
pp. 1288-1298 ◽  
Author(s):  
L Dorstyn ◽  
J Puccini ◽  
C H Wilson ◽  
S Shalini ◽  
M Nicola ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Damage Response ◽  
Genetic Instability ◽  
Damage Response ◽  
Caspase 2

scholarly journals The p53-caspase-2 axis in the cell cycle and DNA damage response

2021 ◽  
Author(s):  
Yoon Lim ◽  
Loretta Dorstyn ◽  
Sharad Kumar
Keyword(s):  
Cell Cycle ◽  
Dna Damage ◽  
Dna Damage Response ◽  
The Other ◽  
Interleukin 1Β ◽  
Converting Enzyme ◽  
High Similarity ◽  
Caspase 9 ◽  
Damage Response ◽  
Caspase 2

AbstractCaspase-2 was discovered almost three decades ago. It was one of the first two mammalian homologs of CED-3, the other being interleukin 1β-converting enzyme (ICE/caspase-1). Despite high similarity with CED-3 and its fly and mammalian counterparts (DRONC and caspase-9, respectively), the function of caspase-2 in apoptosis has remained enigmatic. A number of recent studies suggest that caspase-2 plays an important role in the regulation of p53 in response to cellular stress and DNA damage to prevent the proliferation and accumulation of damaged or aberrant cells. Here, we review these recent observations and their implications in caspase-2-mediated cellular death, senescence, and tumor suppression.

2118-P: Regulation of Ataxia-Telangiectasia and Rad3-Related (ATR)–Dependent DNA Damage Response by Nitric Oxide in ß-Cells

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 2118-P
Author(s):  
CHAY TENG YEO ◽  
BRYNDON OLESON ◽  
JOHN A. CORBETT ◽  
JAMIE K. SCHNUCK
Keyword(s):  
Nitric Oxide ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Ataxia Telangiectasia ◽  
Damage Response
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