scholarly journals Stem cell marker (Nanog) and Stat-3 signaling promote MicroRNA-21 expression and chemoresistance in hyaluronan/CD44-activated head and neck squamous cell carcinoma cells

Oncogene ◽  
2011 ◽  
Vol 31 (2) ◽  
pp. 149-160 ◽  
Author(s):  
L Y W Bourguignon ◽  
C Earle ◽  
G Wong ◽  
C C Spevak ◽  
K Krueger
Keyword(s):  
Squamous Cell Carcinoma ◽  
Stem Cell ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Carcinoma Cells ◽  
Neck Squamous Cell Carcinoma ◽  
Stem Cell Marker ◽  
Cell Marker

6 CD98 identifies a clinically relevant subpopulation of head and neck squamous cell carcinoma cells with stem cell properties

Oral Oncology ◽  
2015 ◽  
Vol 51 (5) ◽  
pp. e29
Author(s):  
S.R. Martens-de Kemp ◽  
M.M. Rietbergen ◽  
A. Brink ◽  
M. Stigter-van Walsum ◽  
E. Bloemena ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Stem Cell ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Carcinoma Cells ◽  
Neck Squamous Cell Carcinoma

Role of cancer stem-cell marker doublecortin-like kinase 1 in head and neck squamous cell carcinoma

Oral Oncology ◽  
2017 ◽  
Vol 67 ◽  
pp. 109-118 ◽  
Author(s):  
Lorenz Kadletz ◽  
Dietmar Thurnher ◽  
Robert Wiebringhaus ◽  
Boban M. Erovic ◽  
Ulana Kotowski ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Stem Cell Marker ◽  
Cancer Stem Cell Marker ◽  
Cell Marker

scholarly journals Cancer cell line microarray as a novel screening method for identification of radioresistance biomarkers in head and neck squamous cell carcinoma

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Johannes Routila ◽  
Karri Suvila ◽  
Reidar Grénman ◽  
Ilmo Leivo ◽  
Jukka Westermarck ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Stem Cell ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Cell Line ◽  
Cell Lines ◽  
Squamous Cell ◽  
Stem Cell Marker ◽  
Cell Marker ◽  
Hnscc Cell

Abstract Background Currently, no clinically useful biomarkers for radioresistance are available in head and neck squamous cell carcinoma (HNSCC). This study assesses the usefulness of Cell Line Microarray (CMA) method to enhance immunohistochemical screening of potential immunohistochemical biomarkers for radioresistance in HNSCC cell lines. Methods Twenty-nine HNSCC cell lines were cultured, cell pellets formalin-fixed, paraffin-embedded, and arrayed. Radioresistance features of the cell lines were combined to immunohistochemical stains for p53, NDFIP1, EGFR, stem cell marker Oct4, and PP2A inhibitor CIP2A. Results Expression of p53, EGFR or CIP2A did not indicate intrinsic radioresistance in vitro. Stem cell marker Oct4 nuclear positivity and NDFIP1 nuclear positivity was correlated with increased intrinsic radioresistance. Conclusion The usefulness of CMA in analysis of HNSCC cell lines and discovery of biomarkers is demonstrated. CMA is very well adapted to both testing of antibodies in a large panel of cell lines as well as correlating staining results with other cell line characteristics. In addition, CMA-based antibody screening proved an efficient and relatively simple method to identify potential radioresistance biomarkers in HNSCC.

Significance of site-specific prognosis of cancer stem cell marker CD44 in head and neck squamous-cell carcinoma

Oral Oncology ◽  
2011 ◽  
Vol 47 (6) ◽  
pp. 510-516 ◽  
Author(s):  
Linda-Lotta Kokko ◽  
Saija Hurme ◽  
Sanna-Mari Maula ◽  
Kalle Alanen ◽  
Reidar Grénman ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Stem Cell Marker ◽  
Cancer Stem Cell Marker ◽  
Cell Marker ◽  
Site Specific

scholarly journals CD98 marks a subpopulation of head and neck squamous cell carcinoma cells with stem cell properties

2013 ◽  
Vol 10 (3) ◽  
pp. 477-488 ◽  
Author(s):  
Sanne R. Martens-de Kemp ◽  
Arjen Brink ◽  
Marijke Stigter-van Walsum ◽  
J. Mirjam A. Damen ◽  
François Rustenburg ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Stem Cell ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Carcinoma Cells ◽  
Neck Squamous Cell Carcinoma
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