scholarly journals Chronic hypoxia increases peroxynitrite, MMP9 expression, and collagen accumulation in fetal guinea pig hearts

2011 ◽  
Vol 71 (1) ◽  
pp. 25-31 ◽  
Author(s):  
LaShauna C. Evans ◽  
Hongshan Liu ◽  
Gerard A. Pinkas ◽  
Loren P. Thompson
Keyword(s):  
Guinea Pig ◽  
Chronic Hypoxia ◽  
Mmp9 Expression ◽  
Collagen Accumulation

Sex Differences in Right Ventricular-Vascular Coupling and Pulmonary Artery Impedance in Response to Chronic Hypoxia and Recovery

2012 ◽  
Author(s):  
Aiping Liu ◽  
Lian Tian ◽  
Diana M. Tabima ◽  
Naomi C. Chesler
Keyword(s):  
Pulmonary Artery ◽  
Chronic Hypoxia ◽  
Pulmonary Arteries ◽  
Pulmonary Artery Hypertension ◽  
Vascular Impedance ◽  
Female Predominance ◽  
Collagen Accumulation ◽  
Dominant Disease ◽  
Pulmonary Arterial

Pulmonary artery hypertension (PAH) is a female dominant disease (the female-to-male ratio is 4:1), characterized by small distal pulmonary arterial narrowing and large proximal arterial stiffening, which increase right ventricle (RV) afterload and ultimately lead to RV failure [1,2]. Our recent studies have shown that collagen accumulation induced by chronic hypoxia increases the stiffness of the large extralobar pulmonary arteries (PAs) [3], and affects pulmonary vascular impedance (PVZ) [4]. The role of collagen in the female predominance in developing PAH has not been explored to date.

scholarly journals Chronic Hypoxia Impairs Cytochrome Oxidase Activity Via Oxidative Stress in Selected Fetal Guinea Pig Organs

2012 ◽  
Vol 20 (3) ◽  
pp. 299-307 ◽  
Author(s):  
Yazan M. Al-Hasan ◽  
LaShauna C. Evans ◽  
Gerard A. Pinkas ◽  
Erinne R. Dabkowski ◽  
William C. Stanley ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Guinea Pig ◽  
Cytochrome Oxidase ◽  
Oxidase Activity ◽  
Chronic Hypoxia ◽  
Cytochrome Oxidase Activity

scholarly journals Chronic hypoxia differentially increases glutathione content and γ-glutamyl cysteine synthetase expression in fetal guinea pig organs

2008 ◽  
Vol 84 (2) ◽  
pp. 121-127 ◽  
Author(s):  
Chien Oh ◽  
Yafeng Dong ◽  
Christopher Harman ◽  
Hugh E. Mighty ◽  
Jerome Kopelman ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Chronic Hypoxia ◽  
Cysteine Synthetase

scholarly journals Persistent vascular collagen accumulation alters hemodynamic recovery from chronic hypoxia

2012 ◽  
Vol 45 (5) ◽  
pp. 799-804 ◽  
Author(s):  
Diana M. Tabima ◽  
Alejandro Roldan-Alzate ◽  
Zhijie Wang ◽  
Timothy A. Hacker ◽  
Robert C. Molthen ◽  
...  
Keyword(s):  
Chronic Hypoxia ◽  
Collagen Accumulation
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