Unclassified low grade spindle cell sarcoma with storiform pattern characterized by recurrent novel EWSR1/FUS-NACC1 fusions

Müllerian adenosarcoma is an uncommon biphasic tumor composed of malignant stromal and benign epithelial components. Morphologically, adenosarcoma is characterized by a broad leaflike architecture, reminiscent of phyllodes tumors of the breast. Periglandular cuffing of the stromal cells around the compressed or cystically dilated glands is characteristic. The mesenchymal component is typically a low-grade spindle cell sarcoma, whereas the epithelial counterpart is commonly endometrioid with frequent squamous or mucinous metaplasia and may, in some circumstances, show mild to moderate atypia. In all cases, it is important to assess for the presence of sarcomatous overgrowth and myometrial invasion, which are the prognostic factors. In this brief review, we present the clinical, histopathologic, and immunohistochemical features of adenosarcoma, as well as updates on the molecular biology of this neoplasm.

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Spindle Cell Sarcoma of Submandibular Salivary Gland: A Rare Presentation

International Journal of Head and Neck Surgery ◽

10.5005/jp-journals-10001-1070 ◽

2011 ◽

Vol 2 (3) ◽

pp. 144-145

Author(s):

Priti Rakesh Dhoke ◽

Vivek Vishwasji Harkare ◽

Nitin Vasant Deosthale ◽

Sonali Prabhakar Khadakkar ◽

Kanchan Sandeep Dhote ◽

...

Keyword(s):

Salivary Gland ◽

Spindle Cell ◽

Postoperative Radiotherapy ◽

Vascular Tumor ◽

Spindle Cell Sarcoma ◽

Submandibular Salivary Gland ◽

Low Grade ◽

Rare Presentation ◽

Cell Sarcoma ◽

High Degree

ABSTRACT Objective To report a rare case of spindle cell sarcoma of submandibular salivary gland, with intraoral extension with pathological dilemma. Case report A 40-year-old male presented with swelling and pain in right submandibular area since 1 year. Right submandibular gland excision with intraoral mass excision was done with reconstruction of floor of mouth. Postoperative histopathology was suggestive of low-grade malignant tumor with differential diagnosis of acinic cell tumor, vascular tumor and myoepithelial tumor. The immunohistochemistry report revealed spindle cell sarcoma with high degree of vascularity. Based on this report postoperative radiotherapy was planned. Conclusion According to literature, spindle cell sarcoma of submandibular salivary gland has not been reported yet. This case is presented for its uniqueness of its site, extension and histopathological dilemma.

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Unclassified Low-Grade Spindle Cell Sarcoma of the Vulva

American Journal of Clinical Pathology ◽

10.1093/ajcp/140.suppl1.098 ◽

2013 ◽

Vol 140 (suppl 1) ◽

pp. A098-A098

Author(s):

Jennifer Hawkins ◽

Sarah H. Kim ◽

Nigel Pereira ◽

Scott D. Richard ◽

Beth Mapow

Keyword(s):

Spindle Cell ◽

Spindle Cell Sarcoma ◽

Low Grade ◽

Cell Sarcoma

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Marginal Excision of Low-Grade Spindle Cell Sarcoma of Canine Extremities: 35 Dogs (19962006)

Veterinary Surgery ◽

10.1111/j.1532-950x.2008.00408.x ◽

2008 ◽

Vol 37 (5) ◽

pp. 461-465 ◽

Cited By ~ 57

Author(s):

DAMIANO STEFANELLO ◽

EMANUELA MORELLO ◽

PAOLA ROCCABIANCA ◽

SELINA IUSSICH ◽

CLAUDIA NASSUATO ◽

...

Keyword(s):

Spindle Cell ◽

Spindle Cell Sarcoma ◽

Low Grade ◽

Cell Sarcoma ◽

Marginal Excision

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Low grade spindle cell sarcoma of the true vocal folds

Otolaryngology Case Reports ◽

10.1016/j.xocr.2017.11.006 ◽

2018 ◽

Vol 7 ◽

pp. 13-15

Author(s):

Samuel R. Barber ◽

Pavel Kopach ◽

Elizabeth M. Genega ◽

Thomas L. Carroll

Keyword(s):

Spindle Cell ◽

Vocal Folds ◽

Spindle Cell Sarcoma ◽

Low Grade ◽

Cell Sarcoma

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Ultrastructure of mesotheliomas

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100110775 ◽

1984 ◽

Vol 42 ◽

pp. 98-101

Author(s):

Irving Dardick

Keyword(s):

Electron Microscopy ◽

Latent Period ◽

Spindle Cell ◽

Spindle Cell Sarcoma ◽

Metastatic Adenocarcinoma ◽

Cell Sarcoma ◽

Cytological Features ◽

Industrial Use ◽

Degree Of Differentiation

With the extensive industrial use of asbestos in this century and the long latent period (20-50 years) between exposure and tumor presentation, the incidence of malignant mesothelioma is now increasing. Thus, surgical pathologists are more frequently faced with the dilemma of differentiating mesothelioma from metastatic adenocarcinoma and spindle-cell sarcoma involving serosal surfaces. Electron microscopy is amodality useful in clarifying this problem.In utilizing ultrastructural features in the diagnosis of mesothelioma, it is essential to appreciate that the classification of this tumor reflects a variety of morphologic forms of differing biologic behavior (Table 1). Furthermore, with the variable histology and degree of differentiation in mesotheliomas it might be expected that the ultrastructure of such tumors also reflects a range of cytological features. Such is the case.

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