scholarly journals Correction: Impact of energy turnover on the regulation of glucose homeostasis in healthy subjects

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Franziska Büsing ◽  
Franziska Anna Hägele ◽  
Alessa Nas ◽  
Mario Hasler ◽  
Manfred James Müller ◽  
...  
Keyword(s):  
Glucose Homeostasis ◽  
Healthy Subjects ◽  
Energy Turnover

Since publication of this article the authors noted that the legend for Table 1 was incomplete, as the subtitle was missing. The complete table should appear as given below. This has been corrected in both the PDF and HTML versions of the Article.

scholarly journals Impact of energy turnover on the regulation of glucose homeostasis in healthy subjects

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Franziska Büsing ◽  
Franziska Anna Hägele ◽  
Alessa Nas ◽  
Mario Hasler ◽  
Manfred James Müller ◽  
...  
Keyword(s):  
Glucose Homeostasis ◽  
Healthy Subjects ◽  
Energy Turnover

Plasma GSH/GSSG affects glucose homeostasis in healthy subjects and non-insulin-dependent diabetics

1992 ◽  
Vol 263 (3) ◽  
pp. E435-E440 ◽  
Author(s):  
G. Paolisso ◽  
G. Di Maro ◽  
G. Pizza ◽  
A. D'Amore ◽  
S. Sgambato ◽  
...  
Keyword(s):  
Glucose Homeostasis ◽  
Healthy Subjects ◽  
Relative Increase ◽  
Glucose Disposal ◽  
Simultaneous Increase ◽  
Diabetic Patients ◽  
Hormonal Changes ◽  
Arterial Blood ◽  
Type Ii Diabetics ◽  
Insulin Dependent

In healthy subjects (n = 10) and non-insulin-dependent (type II) diabetics (n = 10) matched for age [43.1 +/- 2.2 vs. 41 +/- 4.4 yr, P = not significant (NS)], body mass index (25.1 +/- 1.1 vs. 26 +/- 0.8 kg/m2, P = NS), gender ratio [5 males (M)/5 females (F) vs. 5M/5F], and mean arterial blood pressure (105 +/- 7 vs. 106 +/- 9 mmHg, P = NS), we determined the changes in insulin secretion and action after glutathione infusion (15 mg/min) and the relative increase in the plasma reduced (GSH)/oxidized (GSSG) glutathione ratio. The rise in the plasma GSH/GSSG ratio significantly improved total body glucose disposal in healthy subjects and in diabetic patients. In this latter group, GSH infusion potentiated the beta-cell response to glucose slightly. In controls and diabetics, insulin infusion with a simultaneous increase in the plasma GSH/GSSG ratio significantly enhanced nonoxidative glucose disposal without affecting oxidative glucose metabolism. After glutathione infusion, all metabolic and hormonal changes correlated with a significant decline in plasma membrane microviscosity. In conclusion, the plasma GSH/GSSG ratio seems to play a major role in the modulation of glucose homeostasis mainly in diabetics.

Serum Vitamin D Status, Vitamin D Receptor Polymorphism, and Glucose Homeostasis in Healthy Subjects

2017 ◽  
Vol 50 (01) ◽  
pp. 56-64 ◽  
Author(s):  
Otto Mayer ◽  
Jitka Seidlerová ◽  
Václava Černá ◽  
Alena Kučerová ◽  
Petra Karnosová ◽  
...  
Keyword(s):  
Vitamin D ◽  
Insulin Sensitivity ◽  
Vitamin D Receptor ◽  
Glucose Homeostasis ◽  
Healthy Subjects ◽  
Model Assessment ◽  
Vitamin D Status ◽  
Cell Secretion ◽  
Β Cell ◽  
Vdr Polymorphism

AbstractLow vitamin D status has been frequently associated with impaired glucose metabolism. We examined associations between 25-hydroxyvitamin D (25-OH-D) and several parameters of glucose homeostasis in virtually healthy subjects, and explored possible interaction with vitamin D receptor (VDR) polymorphism. Nondiabetic subjects without chronic medication or any known significant manifest disease were selected from large general-population based population survey. Insulin sensitivity and β cell secretion were calculated by homeostasis model assessment (HOMA) and soluble isoform of receptor for advanced glycation end-products (sRAGE) using commercial ELISA. Subjects were also genotyped for rs2228570 polymorphism of VDR. After adjustment for potential confounders, we observed a significant relationship between 25-OH-D and fasting glycemia (β coefficient=–5.904; p=0.002) or insulin sensitivity (β=0.042; p=0.001), but not with β cell secretion or sRAGE. We found also an interaction with VDR polymorphism. Subjects with low 25-OH-D and AA genotype had significantly lower insulin sensitivity than those with GG genotype plus highest 25-OH-D concentrations (107.3% vs. 183.9%, p=0.021). In conclusion, low vitamin D status was in virtually healthy subjects associated with decreased insulin sensitivity, namely in those with GG genotype of rs2228570 VDR polymorphism.

Reflex Responses in Upper Limb Muscles to Cutaneous Stimuli

1993 ◽  
Vol 20 (04) ◽  
pp. 271-278 ◽  
Author(s):  
R. Chen
Keyword(s):  
Stimulus Intensity ◽  
Upper Limb ◽  
Healthy Subjects ◽  
Voluntary Contraction ◽  
Cutaneous Reflexes ◽  
Focal Lesions ◽  
Normal Ranges ◽  
Conduction Velocities ◽  
Limb Muscles ◽  
Biphasic Responses

ABSTRACT:Cutaneous reflexes in the upper limb were elicited by stimulating digital nerves and recorded by averaging rectified EMG from proximal and distal upper limb muscles during voluntary contraction. Distal muscles often showed a triphasic response: an inhibition with onset about 50 ms (Il) followed by a facilitation with onset about 60 ms (E2) followed by another inhibition with onset about 80 ms (12). Proximal muscles generally showed biphasic responses beginning with facilitation or inhibition with onset at about 40 ms. Normal ranges for the amplitude of these components were established from recordings on 22 arms of 11 healthy subjects. An attempt was made to determine the alterent fibers responsible for the various components by varying the stimulus intensity, by causing ischemic block of larger fibers and by estimating the afferent conduction velocities. The central pathways mediating these reflexes were examined by estimating central delays and by studying patients with focal lesions

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