Background:Axial spondyloarthritis (axSpA) is a chronic inflammatory disease of the sacroiliac joints and spine. Lipid profiles, including total cholesterol(TC), high-density lipoprotein cholesterol(HDL-c), low-density lipoprotein cholesterol (LDL-c), TC/HDL-c, triglycerides(TG), have been reported to be changed regularly in axSpA patients. However, the clinical significance of lipid profiles in axSpA patients is controversial.Objectives:The study aims to determine the clinical significance of TC, HDL-c, LDL-c, TC/HDL-c, TG for axSpA patients.Methods:A total of 208 axSpA patients and 113 healthy subjects were enrolled in the study retrospectively. TC, HDL-c, LDL-c, TC/HDL-c, TG, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), Bath Ankylosing Spondylitis Disease Activity Index(BASDAI) were collected. AxSpA patients were divided into remission axSpA group(BASDAI<4, n=123) and active axSpA group(BASDAI≥4, n=85). Relationships between the parameters were assessed by the Sperman’ s correlations analysis. Receiver operation characteristic (ROC) curves were used to discriminate axSpA patients from healthy subjects and active axSpA group from remission axSpA group.Results:TC, HDL-c, and TG in axSpA group were lower than those of control group, while TC/HDL-c was higher (P<0.05). ROC curve results showed that the AUC value of HDL-c for axSpA was 0.790 (CI95%: 0.740-0.839), yielding a highest AUC value. The optimal cutoff value of HDL-c for axSpA was 1.095, with the Youden index of 0.496, sensitivity of 65.5% and specificity of 84.1%. HDL-c was negatively correlated with BASDAI (r=-0.159, P=0.022). TC/HDL-c was positively correlated with BASDAI (r=0.183, P=0.008). Besides, TC/HDL-c, CRP, ESR in active axSpA group were higher than those of remission axSpA group, while HDL-c was lower (P<0.05). ROC curve results showed that the AUC value of TC/HDL-c and CRP for active axSpA group were 0.621 (CI95%: 0.543-0.700) and 0.634 (CI95%: 0.556-0.712), yielding a higher AUC value than other parameters. The optimal cutoff value of TC/HDL-c for active axSpA group was 4.429, with the Youden index of 0.201, sensitivity of 40.2% and specificity of 79.9%.Conclusion:HDL-c was decreased in axSpA patients with a highest diagnostic value, compared with healthy control. TC/HDL-c was elevated in active axSpA patients, showing a significant correlation to the disease activity of axSpA.References:[1]Gluszko P, Bonek K, Rupinski R, et al. LIPID PROFILE AND ACTIVE SYSTEMIC INFLAMMATION MAY DIFFERENTLY AFFECT THE PATHOMECHANISM OF CARDIOVASCULAR DISORDERS IN ANKYLOSING SPONDYLITIS (AS) AND IN PSORIATIC ARTHRITIS (PSA)[J]. ANNALS OF THE RHEUMATIC DISEASES. 2016: 1146.Acknowledgments:This study was supported by Science and Technology Project of Guangzhou Haizhu District (Haike Business Infox 2018-89).Disclosure of Interests:None declared
The Expression and Clinical Significance of Different Forms of Mer Receptor Tyrosine Kinase in Systemic Lupus Erythematosus
