DNA polymerase beta modulates cancer progression via enhancing CDH13 expression by promoter demethylation

Oncogene ◽  
2020 ◽  
Vol 39 (33) ◽  
pp. 5507-5519 ◽  
Author(s):  
Meina Wang ◽  
Kaili Long ◽  
Enjie Li ◽  
Lulu Li ◽  
Binghua Li ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Cancer Progression ◽  
Dna Polymerase Beta ◽  
Polymerase Beta

scholarly journals Chick embryo DNA polymerase beta. Purified enzyme consists of a single Mr = 40,000 polypeptide.

1980 ◽  
Vol 255 (20) ◽  
pp. 9942-9948 ◽  
Author(s):  
M. Yamaguchi ◽  
K. Tanabe ◽  
Y.N. Taguchi ◽  
M. Nishizawa ◽  
T. Takahashi ◽  
...  
Keyword(s):  
Chick Embryo ◽  
Dna Polymerase ◽  
Dna Polymerase Beta ◽  
Polymerase Beta

scholarly journals Studies of the domain structure of mammalian DNA polymerase beta. Identification of a discrete template binding domain.

1990 ◽  
Vol 265 (4) ◽  
pp. 2124-2131
Author(s):  
A Kumar ◽  
S G Widen ◽  
K R Williams ◽  
P Kedar ◽  
R L Karpel ◽  
...  
Keyword(s):  
Domain Structure ◽  
Dna Polymerase ◽  
Binding Domain ◽  
Dna Polymerase Beta ◽  
Polymerase Beta

scholarly journals Involvement of deoxyribonucleic acid polymerase β in nuclear deoxyribonucleic acid synthesis

1978 ◽  
Vol 173 (1) ◽  
pp. 309-314 ◽  
Author(s):  
T R Butt ◽  
W M Wood ◽  
E L McKay ◽  
R L P Adams
Keyword(s):  
Dna Synthesis ◽  
Dna Polymerase ◽  
Deoxyribonucleic Acid ◽  
Nuclear Dna ◽  
Dna Polymerase Beta ◽  
Cell Nuclei ◽  
High Molecular Weight Dna ◽  
Dna Polymerase Alpha ◽  
Polymerase Beta

The effects on DNA synthesis in vitro in mouse L929-cell nuclei of differential extraction of DNA polymerases alpha and beta were studied. Removal of all measurable DNA polymerase alpha and 20% of DNA polymerase beta leads to a 40% fall in the replicative DNA synthesis. Removal of 70% of DNA polymerase beta inhibits replicative synthesis by 80%. In all cases the nuclear DNA synthesis is sensitive to N-ethylmaleimide and aCTP (arabinosylcytosine triphosphate), though less so than DNA polymerase alpha. Addition of deoxyribonuclease I to the nuclear incubation leads to synthesis of high-molecular-weight DNA in a repair reaction. This occurs equally in nuclei from non-growing or S-phase cells. The former nuclei lack DNA polymerase alpha and the reaction reflects the sensitivity of DNA polymerase beta to inhibiton by N-ethylmaleimide and aCTP.

scholarly journals The Tyr-265-to-Cys mutator mutant of DNA polymerase beta induces a mutator phenotype in mouse LN12 cells

1999 ◽  
Vol 96 (17) ◽  
pp. 9580-9585 ◽  
Author(s):  
C. A. Clairmont ◽  
L. Narayanan ◽  
K.-W. Sun ◽  
P. M. Glazer ◽  
J. B. Sweasy
Keyword(s):  
Dna Polymerase ◽  
Dna Polymerase Beta ◽  
Mutator Phenotype ◽  
Polymerase Beta
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