Variation within voltage-gated calcium channel genes and antipsychotic treatment response in a South African first episode schizophrenia cohort

2018 ◽  
Vol 19 (1) ◽  
pp. 109-114 ◽  
Author(s):  
Kevin S. O’Connell ◽  
Nathaniel W. McGregor ◽  
Anil Malhotra ◽  
Todd Lencz ◽  
Robin Emsley ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Treatment Response ◽  
South African ◽  
First Episode ◽  
Antipsychotic Treatment ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channel ◽  
First Episode Schizophrenia

scholarly journals Predictors of antipsychotic treatment response in patients with first-episode schizophrenia, schizoaffective and schizophreniform disorders

2004 ◽  
Vol 185 (1) ◽  
pp. 18-24 ◽  
Author(s):  
Diana O. Perkins ◽  
Jeffrey A. Lieberman ◽  
Hongbin Gu ◽  
Mauricio Tohen ◽  
Joseph McEvoy ◽  
...  
Keyword(s):  
Clinical Response ◽  
Treatment Response ◽  
Negative Symptoms ◽  
Positive Symptom ◽  
First Episode ◽  
Antipsychotic Treatment ◽  
Duration Of Untreated Psychosis ◽  
First Episode Schizophrenia ◽  
Relationship Of ◽  
The Relationship

BackgroundDuration of untreated psychosis (DUP) may contribute to the observed heterogeneity of the treatment response in first-episode schizophrenia.AimsTo examine the relationship of DUP and premorbid function with clinical outcomes following up to 2 years of antipsychotic treatment.MethodFor a subsample (n = 191) of subjects participating in a clinical trial, DUP and premorbid function were prospectively compared with clinical response to olanzapine or haloperidol.ResultsShorter DUP and good premorbid function each independently are associated with better clinical response, including improvement in overall psychopathology and negative symptoms. Premorbid function also is associated with positive symptom, social and vocational outcomes.ConclusionsEarlier antipsychotic treatment is associated with better outcomes in first-episode schizophrenia. Poor premorbid function could indicate an illness subtype less likely to respond to antipsychotic treatment regardless of when it is instituted.

Modification of the association between antipsychotic treatment response and childhood adversity by MMP9 gene variants in a first-episode schizophrenia cohort

2018 ◽  
Vol 262 ◽  
pp. 141-148 ◽  
Author(s):  
Nathaniel McGregor ◽  
Nicole Thompson ◽  
Kevin Sean O’Connell ◽  
Robin Emsley ◽  
Lize van der Merwe ◽  
...  
Keyword(s):  
Treatment Response ◽  
Childhood Adversity ◽  
First Episode ◽  
Antipsychotic Treatment ◽  
Gene Variants ◽  
First Episode Schizophrenia ◽  
Mmp9 Gene

Patterns of variation influencing antipsychotic treatment outcomes in South African first-episode schizophrenia patients

2014 ◽  
Vol 15 (2) ◽  
pp. 189-199 ◽  
Author(s):  
Britt I Drogemöller ◽  
Dana JH Niehaus ◽  
Bonginkosi Chiliza ◽  
Lize van der Merwe ◽  
Laila Asmal ◽  
...  
Keyword(s):  
Treatment Outcomes ◽  
South African ◽  
First Episode ◽  
Antipsychotic Treatment ◽  
First Episode Schizophrenia

The identification of novel genetic variants associated with antipsychotic treatment response outcomes in first-episode schizophrenia patients

2016 ◽  
Vol 26 (5) ◽  
pp. 235-242 ◽  
Author(s):  
Britt I. Drögemöller ◽  
Robin Emsley ◽  
Bonginkosi Chiliza ◽  
Lize van der Merwe ◽  
Galen E.B. Wright ◽  
...  
Keyword(s):  
Treatment Response ◽  
Genetic Variants ◽  
First Episode ◽  
Antipsychotic Treatment ◽  
First Episode Schizophrenia
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