Posterior reversible encephalopathy syndrome (PRES) after haploidentical haematopoietic stem cell transplantation: incidence, risk factors and outcomes

2020 ◽  
Vol 55 (10) ◽  
pp. 2035-2042 ◽  
Author(s):  
Qi Chen ◽  
Xin Zhao ◽  
Hai-Xia Fu ◽  
Yu-Hong Chen ◽  
Yuan-Yuan Zhang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Posterior Reversible Encephalopathy Syndrome ◽  
Haematopoietic Stem Cell Transplantation ◽  
Haematopoietic Stem Cell ◽  
Posterior Reversible Encephalopathy ◽  
Incidence Risk ◽  
Reversible Encephalopathy

scholarly journals Neuroimaging Findings of Posterior Reversible Encephalopathy Syndrome (PRES) Following Hematopoietic Stem Cell Transplantation in Pediatric Recipients

2021 ◽  
Author(s):  
Ali Onder Atca ◽  
Berrin Erok ◽  
Selime Aydogdu
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Posterior Reversible Encephalopathy Syndrome ◽  
Hematopoietic Stem ◽  
Posterior Reversible Encephalopathy ◽  
Reversible Encephalopathy

Abstract Background: Hematopoietic stem cell transplantation (HSCT) is the intravenous infusion of hematopoietic progenitor cells derived from bone marrow, umblical cord blood or peripheral blood to restore hematologic and immunologic functions of bone marrow. HSCT is the only curative treatment in many childhood disorders and is used worldwide. However, serious complications are still an important concern of management. Central nervous system (CNS) complications in pediatric HSCT recipients can be associated with high morbidity and mortality. Posterior reversible encephalopathy syndrome (PRES) is the most common of these neuroimaging abnormalities in patients having neurological symptoms following HSCT. The most common presentation is posterior encephalopathy in which the lesions are located at the posterior parts of cerebral hemispheres, namely parietooccipital lobes. However, it can also be found in non-posterior distribution and can be accompanied by various atypical imaging manifestattions like restricted diffusion. Methods: In this study, we aimed to describe the typical and also uncommon neuroimaging manifestations of PRES following HSCT in our pediatric patients.We evaluated the medical records of 300 pediatric HSCT recipients.Results: We detected 14 cases of PRES, of which there were 3 cases of atypical neuroimaging manifestations, regarding both the sites of involvement and also the magnetic resonance imaging (MRI) manifestations. Conclusion: Such different presentations should not dissuade the diagnosis of PRES in the appropriate clinical settings in order to manage these patients timely and accurately.

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