scholarly journals BRCA1/2 testing: therapeutic implications for breast cancer management

2018 ◽  
Vol 119 (2) ◽  
pp. 141-152 ◽  
Author(s):  
Nadine M. Tung ◽  
Judy E. Garber
Cancers ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 4233
Author(s):  
Joshua J. Li ◽  
Julia Y. Tsang ◽  
Gary M. Tse

The tumor microenvironment (TME) in breast cancer comprises local factors, cancer cells, immune cells and stromal cells of the local and distant tissues. The interaction between cancer cells and their microenvironment plays important roles in tumor proliferation, propagation and response to therapies. There is increasing research in exploring and manipulating the non-cancerous components of the TME for breast cancer treatment. As the TME is now increasingly recognized as a treatment target, its pathologic assessment has become a critical component of breast cancer management. The latest WHO classification of tumors of the breast listed stromal response pattern/fibrotic focus as a prognostic factor and includes recommendations on the assessment of tumor infiltrating lymphocytes and PD-1/PD-L1 expression, with therapeutic implications. This review dissects the TME of breast cancer, describes pathologic assessment relevant for prognostication and treatment decision, and details therapeutic options that interacts with and/or exploits the TME in breast cancer.


2010 ◽  
Vol 76 (1) ◽  
pp. 13-35 ◽  
Author(s):  
Monica Giovannini ◽  
Daniela Aldrighetti ◽  
Patrizia Zucchinelli ◽  
Carmen Belli ◽  
Eugenio Villa

The Breast ◽  
2011 ◽  
Vol 20 ◽  
pp. S3-S11 ◽  
Author(s):  
Nagi S. El Saghir ◽  
Clement A. Adebamowo ◽  
Benjamin O. Anderson ◽  
Robert W. Carlson ◽  
Peter A. Bird ◽  
...  

Breast Cancer ◽  
2018 ◽  
pp. 3-97
Author(s):  
Adnan Aydiner ◽  
Abdullah Igci ◽  
Neslihan Cabioglu ◽  
Leyla Ozer ◽  
Fatma Sen ◽  
...  

2013 ◽  
Vol 7 (11-12) ◽  
pp. 761
Author(s):  
Nathan Y Hoy ◽  
Peter Metcalfe

Survival to adulthood in spina bifida has greatly increased with the advent of modern therapies. With this prolonging of life expectancy, patients are exposed to the risk of adult onset malignancies and the complications of subsequent treatment. We present the case of a 66-year-old woman born with a terminal lipomyelomeningocele, presenting with new fecal incontinence and a desire to undivert her ileal conduit. The deterioration was attributed to chemotherapy for breast cancer. We highlight the urologic challenges of breast cancer management in the neurogenic bowel population, as well as the utility of an adult spina bifida clinic. To the best of our knowledge, this is the first case report of a spina bifida patient presenting with fecal and urinary complications from breast cancer chemotherapy.


2008 ◽  
Vol 11 (12) ◽  
Author(s):  
E. M. Umoh ◽  
N. Arora ◽  
R. M. Simmons

AbstractSurgical management of breast carcinoma has evolved to include more breast conserving techniques such as skin-, nipple-, and areola-sparing mastectomies, as improved cosmesis becomes an increasing concern. However, the oncologic risk of these procedures must be strongly considered before such techniques can be widely adopted. Here we review available literature on these techniques and their associated clinical outcome. From our own experience, as well as from that reported, we conclude that nipple-, skin-, and areola-sparing mastectomies in carefully selected patients can have safe oncologic outcomes comparable to more traditional surgical techniques and therefore may be a feasible option for breast cancer management.


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