Detection of gluten immunogenic peptides and the Celiac Disease Adherence Test to monitor gluten-free diet: a pilot study

2022 ◽  
Author(s):  
Gry Irene Skodje ◽  
Frida van Megen ◽  
Marianne Stendahl ◽  
Christine Henriksen ◽  
Knut Erik Aslaksen Lundin ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Pilot Study ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Immunogenic Peptides ◽  
Adherence Test

Detection of Gluten Immunogenic Peptides in Feces and Urine in Patients with Celiac Disease on a Gluten-Free Diet

2017 ◽  
Vol 152 (5) ◽  
pp. S163
Author(s):  
Emilia Sugai ◽  
Ana Costa ◽  
Ma. de la Paz Temprano ◽  
Sonia I. Niveloni ◽  
Edgardo Smecuol ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Immunogenic Peptides

scholarly journals Challenges of Monitoring the Gluten-Free Diet Adherence in the Management and Follow-Up of Patients with Celiac Disease

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2274
Author(s):  
Herbert Wieser ◽  
Ángela Ruiz-Carnicer ◽  
Verónica Segura ◽  
Isabel Comino ◽  
Carolina Sousa
Keyword(s):  
Celiac Disease ◽  
Clinical Symptoms ◽  
Poor Quality ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Free Products ◽  
Immunogenic Peptides ◽  
Immune Mediated ◽  
Strict Diet

Celiac disease (CD) is a chronic gluten-responsive immune mediated enteropathy and is treated with a gluten-free diet (GFD). However, a strict diet for life is not easy due to the ubiquitous nature of gluten. This review aims at examining available evidence on the degree of adherence to a GFD, the methods to assess it, and the barriers to its implementation. The methods for monitoring the adherence to a GFD are comprised of a dietary questionnaire, celiac serology, or clinical symptoms; however, none of these methods generate either a direct or an accurate measure of dietary adherence. A promising advancement is the development of tests that measure gluten immunogenic peptides in stools and urine. Causes of adherence/non-adherence to a GFD are numerous and multifactorial. Inadvertent dietary non-adherence is more frequent than intentional non-adherence. Cross-contamination of gluten-free products with gluten is a major cause of inadvertent non-adherence, while the limited availability, high costs, and poor quality of certified gluten-free products are responsible for intentionally breaking a GFD. Therefore, several studies in the last decade have indicated that many patients with CD who follow a GFD still have difficulty controlling their diet and, therefore, regularly consume enough gluten to trigger symptoms and damage the small intestine.

Teaching Families of Children with Celiac Disease about Gluten-Free Diet Using Distributed Education: a Pilot Study

2020 ◽  
pp. 1-3
Author(s):  
Mohsin Rashid ◽  
Jennifer Haskett ◽  
Lisa Parkinson McGraw ◽  
Angela Noble ◽  
Johan van Limbergen ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Pilot Study ◽  
Tertiary Care ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Pediatric Hospital ◽  
Maritime Provinces ◽  
Travel Costs ◽  
Item Questionnaire ◽  
Regional Hospitals

Introduction: Treatment of celiac disease is a strict life-long gluten-free diet (GFD). The GFD is complex, and counseling by a dietitian is essential. The number of new referrals for GFD education has increased. We studied the feasibility of GFD teaching using distributed education. Methods: The IWK Health Center in Halifax is the only tertiary-care pediatric hospital in the 3 Maritime provinces with GFD experienced dietitians. Families travel long distances to attend teaching sessions. Families outside the Halifax area were offered to participate in the 2.5-hour education sessions held once a month via live videoconference link at their regional hospitals. All participants were surveyed with a 10-item questionnaire assessing the content and delivery and usefulness of information. Results: Over a 6-month period, 39 families attended the sessions, 21 locally and 18 at distributed sites across the Maritimes. The survey was completed by 26 participants (67%). All participants at both sites strongly agreed or agreed that their setting was good for learning and the information provided was easy to understand. There were no significant differences between the 2 groups on any individual questions in the 2 domains assessed (all P > 0.06). Conclusions: Distributed education on GFD is feasible and as effective as in person education. It affords convenience and savings to families by reducing travel costs.

scholarly journals Celiac Dietary Adherence Test and Standardized Dietician Evaluation in Assessment of Adherence to a Gluten-Free Diet in Patients with Celiac Disease

Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2300
Author(s):  
Katarzyna Gładyś ◽  
Jolanta Dardzińska ◽  
Marek Guzek ◽  
Krystian Adrych ◽  
Sylwia Małgorzewicz
Keyword(s):  
Celiac Disease ◽  
Tissue Transglutaminase ◽  
Dietary Assessment ◽  
Accurate Method ◽  
Gluten Free Diet ◽  
Dietary Adherence ◽  
Gluten Free ◽  
Extensive Experience ◽  
Food Ingredients ◽  
Adherence Test

Adherence to a gluten-free diet (GFD) is currently the mainstay of treatment strategy for celiac disease (CD). The aim of our study was measuring a GFD adherence in CD patients using two newly validated methods of dietary assessment—Standardized Dietician Evaluation (SDE) and the Celiac Dietary Adherence Test (CDAT). Ninety-two adults with CD were evaluated by a registered dietitian with extensive experience with the use of SDE and CDAT. Duodenal biopsy was performed and blood was drawn for serum anti-endomysial, anti-deamidated gliadin peptide and anti-tissue transglutaminase antibodies in forty four of those patients. The results of CDAT and SDE were very convergent, but SDE scores better correlated with serologic and histologic findings. As many as 24–52% of study participants did not adhere well enough to a GFD. Insufficient adherence to a GFD in CD patients is still a significant problem. The knowledge about gluten content in food ingredients and additives is very low among adults with CD. SDE is the most accurate method in assessing compliance with a GFD and is especially helpful in determining hidden sources of gluten. The CDAT may be a fast tool for screening for a GFD adherence in CD patients.

Use of gluten immunogenic peptides in controlling the adherence to gluten-free diet in patients with celiac disease

2019 ◽  
Vol 493 ◽  
pp. S106
Author(s):  
R. Pérez Garay ◽  
B. Fernández Da Vila ◽  
I. Martínez Roda ◽  
D. Armas Méndez ◽  
S. Domenech Manteca ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Immunogenic Peptides

A Clinical and Histochemical Study of Celiac Disease Before and During a Gluten-Free Diet

1965 ◽  
Vol 48 (2) ◽  
pp. 155-172 ◽  
Author(s):  
I. Michael Samloff ◽  
John S. Davis ◽  
Eric A. Schenk
Keyword(s):  
Celiac Disease ◽  
Histochemical Study ◽  
Gluten Free Diet ◽  
Gluten Free
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