scholarly journals Mapping of quantitative trait loci for life history traits segregating within common frog populations

Heredity ◽  
2019 ◽  
Vol 122 (6) ◽  
pp. 800-808 ◽  
Author(s):  
Gemma Palomar ◽  
Anti Vasemägi ◽  
Freed Ahmad ◽  
Alfredo G. Nicieza ◽  
José Manuel Cano
Keyword(s):  
Life History ◽  
Quantitative Trait Loci ◽  
Quantitative Trait ◽  
Life History Traits ◽  
Common Frog ◽  
Trait Loci

Localization of quantitative trait loci for diapause and other photoperiodically regulated life history traits important in adaptation to seasonally varying environments

2015 ◽  
Vol 24 (11) ◽  
pp. 2809-2819 ◽  
Author(s):  
Venera I. Tyukmaeva ◽  
Paris Veltsos ◽  
Jon Slate ◽  
Emma Gregson ◽  
Hannele Kauranen ◽  
...  
Keyword(s):  
Life History ◽  
Quantitative Trait Loci ◽  
Quantitative Trait ◽  
Life History Traits ◽  
Trait Loci ◽  
Varying Environments

scholarly journals Neutral mutation as the source of genetic variation in life history traits

2005 ◽  
Vol 86 (1) ◽  
pp. 53-63 ◽  
Author(s):  
KRUNOSLAV BRČIĆ-KOSTIĆ
Keyword(s):  
Genetic Variation ◽  
Life History ◽  
Quantitative Trait Loci ◽  
Quantitative Trait ◽  
Life History Traits ◽  
Balancing Selection ◽  
Evolutionary Genetics ◽  
Relative Fitness ◽  
Adaptive Genetic Variation ◽  
Trait Loci

The mechanism underlying the maintenance of adaptive genetic variation is a long-standing question in evolutionary genetics. There are two concepts (mutation–selection balance and balancing selection) which are based on the phenotypic differences between alleles. Mutation – selection balance and balancing selection cannot properly explain the process of gene substitution, i.e. the molecular evolution of quantitative trait loci affecting fitness. I assume that such loci have non-essential functions (small effects on fitness), and that they have the potential to evolve into new functions and acquire new adaptations. Here I show that a high amount of neutral polymorphism at these loci can exist in real populations. Consistent with this, I propose a hypothesis for the maintenance of genetic variation in life history traits which can be efficient for the fixation of alleles with very small selective advantage. The hypothesis is based on neutral polymorphism at quantitative trait loci and both neutral and adaptive gene substitutions. The model of neutral – adaptive conversion (NAC) assumes that neutral alleles are not neutral indefinitely, and that in specific and very rare situations phenotypic (relative fitness) differences between them can appear. In this paper I focus on NAC due to phenotypic plasticity of neutral alleles. The important evolutionary consequence of NAC could be the increased adaptive potential of a population. Loci responsible for adaptation should be fast evolving genes with minimally discernible phenotypic effects, and the recent discovery of genes with such characteristics implicates them as suitable candidates for loci involved in adaptation.

scholarly journals Mapping Quantitative Trait Loci Affecting Life History Traits in the Nematode Caenorhabditis elegans

Genetics ◽  
1996 ◽  
Vol 142 (3) ◽  
pp. 801-817
Author(s):  
David R Shook ◽  
Anne Brooks ◽  
Thomas E Johnson
Keyword(s):  
Life History ◽  
Caenorhabditis Elegans ◽  
Quantitative Trait Loci ◽  
Life Span ◽  
Quantitative Trait ◽  
Life History Traits ◽  
Pleiotropic Effects ◽  
Genetic Component ◽  
Nematode Caenorhabditis Elegans ◽  
Epistatic Effects

Abstract We have identified chromosomal regions containing quantitative trait loci (QTLs) specifying life history traits in recombinant-inbred strains of the nematode Caenorhabditis elegans. This approach also allows us to examine epistatic interactions between loci and pleiotropic effects on different traits at specific loci. QTLs for mean life span were identified on chromosomes II (near stP101), IV (stP5) and the X (stP61), and QTLs for fertility were identified on II (maP1), III (stP19) and IV (stP51). The QTLs for mean life span accounted for 90% of the genetic component of variance. The loci for mean fertility accounted for 88% of the genetic component of variance. Additional QTLs for temperature-sensitive fertility [II (stP36) and V (stP6)] and internal hatching [IV (stP5) were also mapped in these crosses. We found evidence for epistatic effects on mean life span between maP1 and bP1 (V), and for epistatic effects on mean fertility between stP36 and stP6, between stP98 (II) and stP192 (V), between maP1 and stP127 (III), between maP1 and stP103 (X), and between stP5 and stP6. Negatively correlated, pleiotropic effects on mean life span and internal hatching were found linked to stP5.

Identification of cis-regulated genes in quantitative trait loci driving liver fibrosis

2012 ◽  
Vol 50 (08) ◽  
Author(s):  
R Hall ◽  
R Müllenbach ◽  
S Huss ◽  
R Alberts ◽  
K Schughart ◽  
...  
Keyword(s):  
Quantitative Trait Loci ◽  
Liver Fibrosis ◽  
Quantitative Trait ◽  
Trait Loci
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