Nebivolol is more effective than atenolol for blood pressure variability attenuation and target organ damage prevention in L-NAME hypertensive rats

2021 ◽  
Author(s):  
Julieta S. Del Mauro ◽  
Paula D. Prince ◽  
Yanina Santander Plantamura ◽  
Miguel A. Allo ◽  
Luciano Parola ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Variability ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Target Organ ◽  
Hypertensive Rats ◽  
Damage Prevention

Effects of carvedilol or amlodipine on target organ damage in L-NAME hypertensive rats: their relationship with blood pressure variability

2017 ◽  
Vol 11 (4) ◽  
pp. 227-240 ◽  
Author(s):  
Julieta S. Del Mauro ◽  
Paula D. Prince ◽  
Martín Donato ◽  
Nahuel Fernandez Machulsky ◽  
Marcela A. Morettón ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Variability ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Target Organ ◽  
Hypertensive Rats

scholarly journals Beneficial Effects of Paeoniflorin Enriched Extract on Blood Pressure Variability and Target Organ Damage in Spontaneously Hypertensive Rats

2017 ◽  
Vol 2017 ◽  
pp. 1-16 ◽  
Author(s):  
Bo Li ◽  
Zheng-Biao Yang ◽  
Shan-Shan Lei ◽  
Jie Su ◽  
Min-Xia Pang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Variability ◽  
Spontaneously Hypertensive Rats ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Target Organ ◽  
Hypertensive Rats ◽  
Short Term ◽  
Spontaneously Hypertensive ◽  
Radix Paeoniae Alba

Blood pressure variability (BPV) is associated with the development and progression of severe target organ damage (TOD). This study aims to evaluate the protective effect of paeoniflorin enriched extract from Radix Paeoniae Alba (PG) on BPV and TOD in spontaneously hypertensive rats (SHR). All SHR were orally treated with distilled water, metoprolol (MP, 20 mg/kg), and PG (PG-H, 90 mg/kg or PG-L, 30 mg/kg) for a single time or daily for 7 weeks. The 24-hour dynamic blood pressure was monitored and then calculated BPV including long- and short-term systolic blood pressure variability (SBPV), diastolic blood pressure variability (DBPV), mean blood pressure variability (MBPV), and heart rate variability (HRV) as well as the 24-hour-SBP, 24-hour-DBP, and 24-hour-MBP. The protective effects of PG on TOD were observed by histopathologic and biochemical detection. The results indicated that long- and short-term SBPV, DBPV, MBPV, and HRV as well as 24-hour-SBP, 24-hour-DBP, and 24-hour-MBP showed no significant changes after single-dose administration of PG and significantly decreased after administration with PG for 7 weeks. PG could also markedly improve the damage of aorta, heart, kidney, and brain. This study suggested that PG could notably reduce BPV, stabilize blood pressure, and mitigate TOD in SHR.

Correlation between blood pressure variability and subclinical target organ damage in patients with essential hypertension

2019 ◽  
Vol 34 (9) ◽  
pp. 641-647 ◽  
Author(s):  
Mostafa El Mokadem ◽  
Hesham Boshra ◽  
Yasser Abd el Hady ◽  
Amany Kasla ◽  
Ahmed Gouda
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Blood Pressure Variability ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Target Organ

BLOOD PRESSURE VARIABILITY AND SUBCLINICAL TARGET ORGAN DAMAGE: PP.35.472

2010 ◽  
Vol 28 ◽  
pp. e590
Author(s):  
O Azevedo ◽  
F Ferreira ◽  
F Almeida ◽  
C Ferreira ◽  
J Guardado ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Variability ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Target Organ
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