scholarly journals Dynamic network biomarker indicates pulmonary metastasis at the tipping point of hepatocellular carcinoma

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Biwei Yang ◽  
Meiyi Li ◽  
Wenqing Tang ◽  
Weixin Liu ◽  
Si Zhang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Pulmonary Metastasis ◽  
Dynamic Network ◽  
Tipping Point ◽  
Network Biomarker

Understanding migraine using dynamic network biomarkers

Cephalalgia ◽  
2014 ◽  
Vol 35 (7) ◽  
pp. 627-630 ◽  
Author(s):  
Markus A Dahlem ◽  
Jürgen Kurths ◽  
Michel D Ferrari ◽  
Kazuyuki Aihara ◽  
Marten Scheffer ◽  
...  
Keyword(s):  
Mathematical Modeling ◽  
Mathematical Models ◽  
Dynamic Network ◽  
Tipping Point ◽  
Trigger Factors ◽  
Clinical Neuroscience ◽  
Complex Interactions ◽  
Network Biomarker ◽  
Network Biomarkers ◽  
Premonitory Symptoms

Background Mathematical modeling approaches are becoming ever more established in clinical neuroscience. They provide insight that is key to understanding complex interactions of network phenomena, in general, and interactions within the migraine-generator network, in particular. Purpose In this study, two recent modeling studies on migraine are set in the context of premonitory symptoms that are easy to confuse for trigger factors. This causality confusion is explained, if migraine attacks are initiated by a transition caused by a tipping point. Conclusion We need to characterize the involved neuronal and autonomic subnetworks and their connections during all parts of the migraine cycle if we are ever to understand migraine. We predict that mathematical models have the potential to dismantle large and correlated fluctuations in such subnetworks as a dynamic network biomarker of migraine.

scholarly journals Landscape dynamic network biomarker analysis reveals the tipping point of transcriptome reprogramming to prevent skin photodamage

2021 ◽  
Author(s):  
Chengming Zhang ◽  
Hong Zhang ◽  
Jing Ge ◽  
Tingyan Mi ◽  
Xiao Cui ◽  
...  
Keyword(s):  
Dynamic Network ◽  
Tipping Point ◽  
Critical Transition ◽  
Skin Model ◽  
Uvb Irradiation ◽  
Network Biomarker ◽  
Skin Response ◽  
Landscape Dynamic ◽  
Skin Lightening ◽  
3D Skin

Abstract Skin, as the outmost layer of human body, is frequently exposed to environmental stressors including pollutants and ultraviolet (UV), which could lead to skin disorders. Generally, skin response process to ultraviolet B (UVB) irradiation is a nonlinear dynamic process, with unknown underlying molecular mechanism of critical transition. Here, the landscape dynamic network biomarker (l-DNB) analysis of time series transcriptome data on 3D skin model was conducted to reveal the complicated process of skin response to UV irradiation at both molecular and network levels. The advanced l-DNB analysis approach showed that: (i) there was a tipping point before critical transition state during pigmentation process, validated by 3D skin model; (ii) 13 core DNB genes were identified to detect the tipping point as a network biomarker, supported by computational assessment; (iii) core DNB genes such as COL7A1 and CTNNB1 can effectively predict skin lightening, validated by independent human skin data. Overall, this study provides new insights for skin response to repetitive UVB irradiation, including dynamic pathway pattern, bi-phasic response, and DNBs for skin lightening change, and enables us to further understand the skin resilience process after external stress.

Role of surgical resection for pulmonary metastasis of hepatocellular carcinoma

Lung Cancer ◽  
2010 ◽  
Vol 70 (3) ◽  
pp. 295-300 ◽  
Author(s):  
Kook Nam Han ◽  
Young Tae Kim ◽  
Jung-Hwan Yoon ◽  
Kyung-Suk Suh ◽  
Ji Yeon Song ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Surgical Resection ◽  
Pulmonary Metastasis

Prolonged survival after repeat resection of pulmonary metastasis from hepatocellular carcinoma

2002 ◽  
Vol 9 (3) ◽  
pp. 386-388 ◽  
Author(s):  
Masanori Aramaki ◽  
Katsunori Kawano ◽  
Atsushi Sasaki ◽  
Toshifumi Matsumoto ◽  
Seiichiro Kai ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Pulmonary Metastasis ◽  
Prolonged Survival ◽  
Repeat Resection

scholarly journals Nomogram for Predicting the Prognosis of Patients with Hepatocellular Carcinoma Presenting with Pulmonary Metastasis

2021 ◽  
Vol Volume 13 ◽  
pp. 2083-2094
Author(s):  
Yongjie Zhou ◽  
Xin Zhou ◽  
Jingqin Ma ◽  
Wen Zhang ◽  
Zhiping Yan ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Pulmonary Metastasis

Mo1417 ADHERENCE TO GUIDELINES FOR SCREENING OF PULMONARY METASTASIS IN PATIENTS WITH HEPATOCELLULAR CARCINOMA: A QUALITY IMPROVEMENT STUDY

2020 ◽  
Vol 158 (6) ◽  
pp. S-1402
Author(s):  
Rebecca Crain ◽  
Dora Richard ◽  
Mohammad Bilal ◽  
Manoj Kathuria ◽  
Olugbenga Ojo ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Quality Improvement ◽  
Pulmonary Metastasis ◽  
Adherence To Guidelines

scholarly journals Herbal Compound “Songyou Yin” Renders Hepatocellular Carcinoma Sensitive to Oxaliplatin through Inhibition of Stemness

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Qing-An Jia ◽  
Zheng-Gang Ren ◽  
Yang Bu ◽  
Zhi-Ming Wang ◽  
Qiang-Bo Zhang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Lines ◽  
Pulmonary Metastasis ◽  
Combination Treatment ◽  
Colony Formation ◽  
Immunohistochemical Analysis ◽  
Hep3b Cell ◽  
Invasion And Migration ◽  
Herbal Compound

We investigated the effect of Chinese herbal compound Song-you Yin on HCC stemness. MHCC97H and Hep3B cell lines were pretreated with SYY for 4 weeks, and their chemosensitivity to oxaliplatin was evaluated. The expression of CSC-related markers, cell invasion and migration, and colony formation were also examined. SYY-treated orthotopic nude mouse models of human HCC were developed to explore the effect of oxaliplatin on tumor growth, metastasis, and survival. The CSC-related molecular changesin vivowere also evaluated. The result showed that MHCC97H and Hep3B cells pretreated with SYY showed significantly increased chemosensitivity to oxaliplatin and the downregulation of CSC-related markers CD90, CD24, and EPCAM. SYY also attenuated cell motility, invasion, and colony formation in MHCC97H and Hep3B cell lines. The reduced tumorigenicity and pulmonary metastasis were observed in SYY-pretreated cell lines. Combination treatment with oxaliplatin and SYY significantly reduced tumor volume and pulmonary metastasis and prolonged survival compared with oxaliplatin treatment alone. Immunohistochemical analysis showed reduced expression of CD90, ABCG2, ALDH, CD44, EPCAM, vimentin, and MMP-9 and increased the expression of E-cadherin, in HCC cells following combination treatment. These data clearly demonstrate that SYY renders hepatocellular carcinoma sensitive to oxaliplatin through the inhibition of stemness.

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