Understanding the reactivity of CoCrMo-implant wear particles

Mohamed A. Koronfel; Angela E. Goode; Johanna Nelson Weker; Stephen E. R. Tay; Camilla A. Stitt; Thiago A. Simoes; J. Frederick. W. Mosselmans; Paul Quinn; Rik Brydson; Alister Hart; Michael F. Toney; Alexandra E. Porter; Mary P. Ryan

doi:10.1038/s41529-018-0029-2

A simple method of suspending implant wear particles for more physiological modelling of cell-particle interactions in vitro

10.1101/2021.01.05.425343 ◽

2021 ◽

Author(s):

Christine Poon

Keyword(s):

Wear Debris ◽

Culture Media ◽

Polymeric Materials ◽

Wear Particle ◽

Physicochemical Characteristics ◽

Wear Particles ◽

Simple Method ◽

Implant Wear

AbstractArthroplasty implants e.g. hip, knee, spinal disc sustain relatively high compressive loading and friction wear, which lead to the formation of wear particles or debris between articulating surfaces. Despite advances in orthopaedic materials and surface treatments, the production of wear debris from any part of a joint arthroplasty implant is currently unavoidable. Implant wear debris induces host immune responses and inflammation, which causes patient pain and ultimately implant failure through progressive inflammation-mediated osteolysis and implant loosening, where the severity and rate of periprosthetic osteolysis depends on the material and physicochemical characteristics of the wear particles. Evaluating the cytotoxicity of implant wear particles is important for regulatory approved clinical application of arthroplasty implants, as is the study of cell-particle response pathways. However, the wear particles of polymeric materials commonly used for arthroplasty implants tend to float when placed in culture media, which limits their contact with cell cultures. This study reports a simple means of suspending wear particles in liquid medium using sodium carboxymethyl cellulose (NaCMC) to provide a more realistic proxy of the interaction between cells and tissues to wear particles in vivo, which are free-floating in synovial fluid within the joint cavity. Low concentrations of NaCMC dissolved in culture medium were found to be effective for suspending polymeric wear particles. Such suspensions may be used as more physiologically-relevant means for testing cellular responses to implant wear debris, as well as studying the combinative effects of shear and wear particle abrasion on cells in a dynamic culture environments such as perfused tissue-on-chip devices.

Download Full-text

New Bio-tribo-mineralogical Expertise Protocol for Joint Implant Wear Particles. Application: Medical Diagnostic and Articular Implants Optimisation

2019 E-Health and Bioengineering Conference (EHB) ◽

10.1109/ehb47216.2019.8969902 ◽

2019 ◽

Author(s):

V. Massardier ◽

M. Vincent ◽

C. Batailler ◽

S. Lustig ◽

J. Geringer ◽

...

Keyword(s):

Wear Particles ◽

Joint Implant ◽

Medical Diagnostic ◽

Implant Wear

Download Full-text

Mutant monocyte chemoattractant protein 1 protein attenuates migration of and inflammatory cytokine release by macrophages exposed to orthopedic implant wear particles

Journal of Biomedical Materials Research Part A ◽

10.1002/jbm.a.34981 ◽

2013 ◽

Vol 102 (9) ◽

pp. 3291-3297 ◽

Cited By ~ 14

Author(s):

Zhenyu Yao ◽

Michael Keeney ◽

Tzu-Hua Lin ◽

Jukka Pajarinen ◽

Katherine Barcay ◽

...

Keyword(s):

Inflammatory Cytokine ◽

Wear Particles ◽

Orthopedic Implant ◽

Cytokine Release ◽

Monocyte Chemoattractant Protein 1 ◽

Monocyte Chemoattractant ◽

Monocyte Chemoattractant Protein ◽

Implant Wear

Download Full-text

Size, Shape, and Spatial Distribution Analysis of Sub-Micron Hip Implant Wear Particles at Sub-Optical Resolution Using Deconvolution Methods

10.17918/etd-4295 ◽

2021 ◽

Author(s):

Andrew Carter Erwin

Keyword(s):

Spatial Distribution ◽

Optical Resolution ◽

Distribution Analysis ◽

Wear Particles ◽

Hip Implant ◽

Implant Wear

Download Full-text

ANALYSIS OF AUTOMATIC TRANSMISSION USING FOURIER TRANSFORM INFRARED (FTIR) SPECTROCOPY

e-Academia Journal ◽

10.24191/e-aj.v7isi-temic18.5378 ◽

2019 ◽

Vol 7 (SI-TeMIC18) ◽

Author(s):

Norhanifah Abdul Rahman ◽

Matzaini Katon Katon ◽

Nurina Alya Zulkifli Zulkifli

Keyword(s):

Fourier Transform ◽

Automatic Transmission ◽

Fourier Transform Infrared ◽

Oil Analysis ◽

Wear Particles ◽

Reliable Technique ◽

Fluid Analysis ◽

Analysis Technique ◽

Machine Elements ◽

Transmission Fluid

Automatic Transmission (AT) system is efficient in the aspects of vehicle safety, comfort, reliability and driving performance. The objectives of this paper are to collect the oil samples from AT systems of engine bus according to manufacturer's recommendations and analyse collected oil samples using oil analysis technique. The sample transmission fluid which was taken from the AT gearbox has been experimentally analyzed. The oil samples were taken with an interval of 5,000km, 30,000km, 50,000km, 80,000km, 180,000km and 300,000km for AT bus operation. These samples then have been analyzed by comparing between new and used transmission fluid using Fourier Transform Infrared (FTIR) spectroscopy. Oil analysis by FTIR is a form of Predictive Maintenance (PdM) to avoid major failure in machine elements. Most machine elements are not easily accessible in the transmission system. Having a reliable technique would avoid the needs to open the components unnecessarily, hence, help to prevent catastrophic failure which are very costly, and ease of regular monitoring. In order to identify the major failures of automatic gearbox, forecasts can be made regarding the lube transmission fluid analysis test. By using this test, the minor problems can be determined before they become major failures. At the end of this research, the wear particles profile for interval mileage of AT system was obtained. Keywords: Wear, Automatic Transmission (AT), Transmission fluid, Fourier Transform Infrared (FTIR), Oil analysis.

Download Full-text