Gut feelings: mechanosensing in the gastrointestinal tract

Author(s):  
Arnaldo Mercado-Perez ◽  
Arthur Beyder
2004 ◽  
Vol 12 (2) ◽  
pp. 217-225 ◽  
Author(s):  
GRAHAM J. DOCKRAY

The obesity epidemic is now widely recognized as a major threat to health in many different countries. Some surgical therapies for obesity are efficacious and indicate that signals from the gastrointestinal tract are capable of exerting beneficial long-term effects on food intake and body weight. The development of non-surgical therapies targeting this system depends on understanding how food, and the absence of food, in the gastrointestinal tract signals to those parts of the brain that regulate feeding behaviour. What can be called gastrointestinal surveillance systems include both nervous pathways linking the gut and brain, and some gut hormones. Nutrient sensing mechanisms within the gastrointestinal tract determine the release of satiety hormones such as cholecystokinin (CCK), or appetite stimulating hormones such as ghrelin, and offer potential therapeutic targets. It seems that CCK and ghrelin both act on the vagus nerve that links the gut to the brain. Examples of interactions between different factors regulating this pathway are discussed. It is argued that sufficient is now known to indicate that this signalling system can provide new targets for the treatment of obesity.


1985 ◽  
Vol 6 (2) ◽  
pp. 52-58 ◽  
Author(s):  
Susan T. Bagley

AbstractThe genus Klebsiella is seemingly ubiquitous in terms of its habitat associations. Klebsiella is a common opportunistic pathogen for humans and other animals, as well as being resident or transient flora (particularly in the gastrointestinal tract). Other habitats include sewage, drinking water, soils, surface waters, industrial effluents, and vegetation. Until recently, almost all these Klebsiella have been identified as one species, ie, K. pneumoniae. However, phenotypic and genotypic studies have shown that “K. pneumoniae” actually consists of at least four species, all with distinct characteristics and habitats. General habitat associations of Klebsiella species are as follows: K. pneumoniae—humans, animals, sewage, and polluted waters and soils; K. oxytoca—frequent association with most habitats; K. terrigena— unpolluted surface waters and soils, drinking water, and vegetation; K. planticola—sewage, polluted surface waters, soils, and vegetation; and K. ozaenae/K. rhinoscleromatis—infrequently detected (primarily with humans).


2001 ◽  
Vol 120 (5) ◽  
pp. A695-A695
Author(s):  
M RUEHL ◽  
I SCHOENFELDER ◽  
R FARNDALE ◽  
G KNIGHT ◽  
R SOMASUNDARAM ◽  
...  

1963 ◽  
Vol 45 (5) ◽  
pp. 625-632 ◽  
Author(s):  
Margot Shiner ◽  
T.E. Waters ◽  
J.D. Allan Gray ◽  
R.A. Lambert

1960 ◽  
Vol 39 (2) ◽  
pp. 191-195 ◽  
Author(s):  
Alice N. Bessman ◽  
George S. Mirick ◽  
Robert Hawkins

1959 ◽  
Vol 37 (1) ◽  
pp. 20-27 ◽  
Author(s):  
Jean A. Spencer ◽  
Carl G. Morlock ◽  
George P. Sayre

1957 ◽  
Vol 32 (6) ◽  
pp. 1013-1024 ◽  
Author(s):  
E. Clinton Texter ◽  
Hubbard W. Smith ◽  
Hugo C. Moeller ◽  
Clifford J. Barborka

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