Janus kinase-targeting therapies in rheumatology: a mechanisms-based approach

Nature Reviews Rheumatology ◽

10.1038/s41584-021-00726-8 ◽

2022 ◽

Author(s):

Yoshiya Tanaka ◽

Yiming Luo ◽

John J. O’Shea ◽

Shingo Nakayamada

Keyword(s):

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Staphylococcal enterotoxins modulate interleukin-2 receptor expression and ligand induced tyrosine phosphorylation of the Janus Kinase 3 (Jak3) and Stat proteins

Immunology Letters ◽

10.1016/s0165-2478(97)87131-3 ◽

1997 ◽

Vol 56 (1-3) ◽

pp. 76

Author(s):

M Nielsen

Keyword(s):

Tyrosine Phosphorylation ◽

Interleukin 2 ◽

Receptor Expression ◽

Janus Kinase ◽

Stat Proteins ◽

Staphylococcal Enterotoxins ◽

Interleukin 2 Receptor ◽

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Embryonic lethality in mice deficient in Janus kinase 2 (JAK2)

Immunology Letters ◽

10.1016/s0165-2478(97)87940-0 ◽

1997 ◽

Vol 56 (1-3) ◽

pp. 275

Author(s):

H Neubauer

Keyword(s):

Embryonic Lethality ◽

Janus Kinase ◽

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Janus Kinase 2 Is Activated by Angiotensin II via G Proteins of the Gi Subfamily in Rat Neonatal Cardiac Myocytes

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(97)84171-x ◽

1998 ◽

Vol 31 (2) ◽

pp. 107A ◽

Author(s):

J Carlsen

Keyword(s):

Angiotensin Ii ◽

Cardiac Myocytes ◽

Janus Kinase ◽

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Effects of Janus Kinase Inhibition in Two Children with Aicardi-Goutières Syndrome

Neuropediatrics ◽

10.1055/s-0037-1602997 ◽

2017 ◽

Vol 48 (S 01) ◽

pp. S1-S45

Author(s):

V. Tüngler ◽

N. König ◽

K. Engel ◽

M. Smitka ◽

K. Ungerath ◽

...

Keyword(s):

Janus Kinase ◽

Kinase Inhibition ◽

Janus Kinase Inhibition

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Faculty Opinions recommendation of Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1016205.200182 ◽

2003 ◽

Author(s):

Gerald Spangrude

Keyword(s):

Allograft Rejection ◽

Janus Kinase ◽

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Faculty Opinions recommendation of Borrelia burgdorferi-induced expression of matrix metalloproteinases from human chondrocytes requires mitogen-activated protein kinase and Janus kinase/signal transducer and activator of transcription signaling pathways.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1019794.225426 ◽

2004 ◽

Author(s):

Timo Korhonen

Keyword(s):

Protein Kinase ◽

Matrix Metalloproteinases ◽

Borrelia Burgdorferi ◽

Signaling Pathways ◽

Janus Kinase ◽

Mitogen Activated Protein Kinase ◽

Human Chondrocytes ◽

Signal Transducer ◽

Induced Expression ◽

Mitogen Activated Protein

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Faculty Opinions recommendation of Tofacitinib, an oral Janus kinase inhibitor, in active ulcerative colitis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717954978.793464633 ◽

2012 ◽

Author(s):

Severine Vermeire

Keyword(s):

Ulcerative Colitis ◽

Kinase Inhibitor ◽

Janus Kinase ◽

Active Ulcerative Colitis ◽

Janus Kinase Inhibitor

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Faculty Opinions recommendation of Discovery and development of Janus kinase (JAK) inhibitors for inflammatory diseases.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718236891.793489638 ◽

2014 ◽

Author(s):

Peter R Bernstein

Keyword(s):

Inflammatory Diseases ◽

Janus Kinase ◽

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Faculty Opinions recommendation of Janus kinase 2/signal transducer and activator of transcription 3 inhibitors attenuate the effect of cardiotrophin-like cytokine factor 1 and human focal segmental glomerulosclerosis serum on glomerular filtration barrier.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725428053.793530397 ◽

2017 ◽

Author(s):

Jochen Reiser

Keyword(s):

Glomerular Filtration ◽

Focal Segmental Glomerulosclerosis ◽

Janus Kinase ◽

Signal Transducer ◽

Janus Kinase 2 ◽

Glomerular Filtration Barrier ◽

Filtration Barrier ◽

Segmental Glomerulosclerosis ◽

Transcription 3

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Faculty Opinions recommendation of The Janus kinase inhibitor ruxolitinib reduces HIV replication in human macrophages and ameliorates HIV encephalitis in a murine model.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726127212.793517951 ◽

2016 ◽

Author(s):

Boris Matija Peterlin

Keyword(s):

Murine Model ◽

Kinase Inhibitor ◽

Janus Kinase ◽

Hiv Replication ◽

Hiv Encephalitis ◽

Janus Kinase Inhibitor ◽

Human Macrophages

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