Faculty Opinions recommendation of Janus kinase 2/signal transducer and activator of transcription 3 inhibitors attenuate the effect of cardiotrophin-like cytokine factor 1 and human focal segmental glomerulosclerosis serum on glomerular filtration barrier.

2017 ◽  
Author(s):  
Jochen Reiser
Keyword(s):  
Glomerular Filtration ◽  
Focal Segmental Glomerulosclerosis ◽  
Janus Kinase ◽  
Signal Transducer ◽  
Janus Kinase 2 ◽  
Glomerular Filtration Barrier ◽  
Filtration Barrier ◽  
Segmental Glomerulosclerosis ◽  
Transcription 3

scholarly journals The role of soluble urokinase-type Plasminogen Activator Receptor (suPAR) in Chronic Kidney Disease

2018 ◽  
Vol 1 (1) ◽  
Author(s):  
Ade Yonata ◽  
Ian Effendi ◽  
Zulkhair Ali ◽  
Novadian Suhaimi ◽  
S Suprapti
Keyword(s):  
Diabetic Nephropathy ◽  
Kidney Disease ◽  
Glomerular Filtration ◽  
Plasminogen Activator ◽  
Focal Segmental Glomerulosclerosis ◽  
Kidney Diseases ◽  
Glomerular Filtration Barrier ◽  
Filtration Barrier ◽  
Type Plasminogen Activator ◽  
Plasminogen Activator Receptor

Kidney disease affects 800 million children and adults worldwide, and the numbers keep increasing. A better understanding of the pathogenesis in kidney diseases, especially on a biomolecular level, is much needed to identify novel biomarkers and therapeutic targets for kidney diseases. The glomerular filtration barrier comprises endothelial cells, the glomerular basement membrane, and podocytes. The podocyte has a central role in part of the glomerular filtration barrier. The nor­mal functioning of podocytes is particularly important in preventing the heavy proteinuria seen in nephrotic syndrome or diabetic nephropathy, or in the disease process of focal segmental glomerulosclerosis. The podocyte is injured by circulating factors, which final­ly results in deranged podocyte motility. Soluble uro­kinase-type plasminogen activator receptor (suPAR) is a circulating form of glycosyl-phosphatidylinositol uPAR domain membrane protein and is known to play a role in the pathogenesis in kidney diseases, specifi­cally focal segmental glomerulosclerosis and diabetic nephropathy. suPAR binds to αvβ3 integrin on podo­cyte foot processes and causes podocyte structure dis­organization leading to glomerular filtration disruption and hence proteinuria. suPAR is also a potential bio­marker to predict the incidence of CKD.

Sign in / Sign up

Export Citation Format

Share Document