scholarly journals Differentiating malignant from benign thyroid nodules with indeterminate cytology by 99mTc-MIBI scan: a new quantitative method for improving diagnostic accuracy

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
A. Campennì ◽  
M. Siracusa ◽  
R. M. Ruggeri ◽  
R. Laudicella ◽  
S. A. Pignata ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Quantitative Method ◽  
Thyroid Nodules ◽  
99Mtc Mibi ◽  
Indeterminate Cytology ◽  
Benign Thyroid Nodules ◽  
Benign Thyroid

scholarly journals Assessment of perinodular stiffness in differentiating malignant from benign thyroid nodules

2021 ◽  
Author(s):  
Lei Hu ◽  
Xiao Liu ◽  
Chong Pei ◽  
Li Xie ◽  
Nianan He
Keyword(s):  
Risk Stratification ◽  
Diagnostic Accuracy ◽  
Thyroid Nodules ◽  
Needle Aspiration ◽  
Fine Needle ◽  
Measurement Function ◽  
Conventional Ultrasound ◽  
Single Method ◽  
Benign Thyroid Nodules ◽  
Benign Thyroid

Objective: We evaluated the diagnostic accuracy of perinodular stiffness, four risk stratification systems (RSSs) (KWAK-TIRADS, ACR-TIRADS, EU-TIRADS, and C-TIRADS), and the combination of perinodular stiffness and these four RSSs in differentiating malignant from benign thyroid nodules (TNs). Methods: A total of 788 TNs in 726 patients were examined with conventional ultrasound (US) examination and sound touch elastography (STE). All TNs were classified by each of the four RSSs. The stiffness inside (E) the TNs was measured by STE. The stiffness of the 2.0mm perinodular region (Eshell) was measured with the Shell measurement function of STE. The diagnostic performances of four RSSs, the E values, and the Eshell values were evaluated. All TNs were further divided into subgroups based on size (≤ 10 mm group and > 10 mm group). Results: Ninety-six TNs were classified as benign and 692 as malignant. Among the single-method approaches, ACR-TIRADS showed the highest AUC (0.77) for differentiating malignant from benign TNs for all TNs included. Eshell showed the highest AUC (0.75) in differentiating malignant from benign TNs for TNs with sizes ≤ 10 mm, and there were no significant differences in AUC among all single methods for diagnosis of TNs with sizes > 10 mm (P > 0.05). The combination of C-TIRADS and Eshell/E yielded the highest AUC for all TNs (0.83) and for TNs with size ≤ 10 mm (0.85) compared with other combinations. Conclusions: Eshell/E combined with conventional US improves the diagnostic accuracy in TNs, and may reduce unnecessary fine needle aspiration.

Preoperative Diagnosis of Benign Thyroid Nodules with Indeterminate Cytology

2012 ◽  
Vol 367 (8) ◽  
pp. 705-715 ◽  
Author(s):  
Erik K. Alexander ◽  
Giulia C. Kennedy ◽  
Zubair W. Baloch ◽  
Edmund S. Cibas ◽  
Darya Chudova ◽  
...  
Keyword(s):  
Preoperative Diagnosis ◽  
Thyroid Nodules ◽  
Indeterminate Cytology ◽  
Benign Thyroid Nodules ◽  
Benign Thyroid

Percutaneous microwave ablation of benign thyroid nodules

2015 ◽  
Vol 54 (01) ◽  
pp. 13-19 ◽  
Author(s):  
F. Nimsdorf ◽  
C. Happel ◽  
H. Ackermann ◽  
F. Grünwald ◽  
H. Korkusuz
Keyword(s):  
Microwave Ablation ◽  
Thyroid Nodules ◽  
Volume Reduction ◽  
Clinical Issue ◽  
New Approach ◽  
99Mtc Mibi ◽  
The Impact ◽  
Percutaneous Microwave Ablation ◽  
Benign Thyroid Nodules ◽  
Benign Thyroid

SummaryAim: Thyroid nodules represent a common clinical issue. Amongst other minimally invasive procedures, percutaneous microwave ablation (MWA) poses a promising new approach. The goal of this retrospective study is to find out if there is a correlation between volume reduction after 3 months and 99mTcuptake reduction of treated thyroid nodules. Patients, methods: 14 patients with 18 nodules were treated with MWA. Pre-ablative assessment included sonographical and functional imaging of the thyroid with 99mTcpertechnetate and 99mTc-MIBI. Additionally, patients underwent thyroid scintigraphy 24 hours after ablation in order to evaluate the impact of the treatment on a functional level and to ensure sufficient ablation of the targeted area. At a 3-month follow-up, ultrasound examination was performed to assess nodular volume reduction. Results: Mean relative nodular volume reduction after three months was 55.4 ± 17.9% (p < 0.05). 99mTcuptake 24 hours after treatment was 45.2 ± 31.9% (99mTc-MIBI) and 35.7 ± 20.3% (99mTcpertechnetate) lower than prior to ablation (p < 0.05). Correlating reduction of volume and 99mTc-uptake, Pearson's r was 0.41 (p < 0.05) for nodules imaged with 99mTc-MIBI and –0.98 (p < 0.05) for 99mTc-pertechnetate. According to scintigraphy 99.6 ± 22.6% of the determined target area could be successfully ablated. Conclusions: MWA can be considered as an efficient, low-risk and convenient new approach to the treatment of benign thyroid nodules. Furthermore, scintigraphy seems to serve as a potential prognostic tool for the later morphological outcome, allowing rapid evaluation of the targeted area in post-ablative examination.

scholarly journals Comparison of Ultrasonography and CT for Determining the Preoperative Benign or Malignant Nature of Thyroid Nodules: Diagnostic Performance According to Calcification

2020 ◽  
Vol 19 ◽  
pp. 153303382094818
Author(s):  
Jian-Hui Wu ◽  
Wei Zeng ◽  
Ren-Guo Wu ◽  
Mei Wang ◽  
Fei Ye ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Thyroid Nodules ◽  
Reference Standard ◽  
Imaging Tool ◽  
Complementary Role ◽  
Lower Accuracy ◽  
Lower Specificity ◽  
Histopathological Results ◽  
Benign Thyroid Nodules ◽  
Benign Thyroid

Background: The present study was designed to investigate the presence or absence of calcification and whether calcification size affect the diagnostic accuracy of ultrasonography (US) and computed tomography (CT) in predicting the benign or malignant nature of thyroid nodules. Material and Methods: From May 2014 to April 2019, 445 patients underwent thyroid US and neck CT before thyroid surgery. In each case, US and CT were retrospectively examined by radiologists. We divided the patients into 3 groups according to the type of calcification: no calcification, microcalcification, and macrocalcification. And macrocalcification group divided into rim calcifications and non-rim calcifications groups. We evaluated the diagnostic accuracy of US and CT for differentiating malignant from benign thyroid nodules using histopathological results as a reference standard. Results: In the overall population, adding CT to US resulted in greater sensitivity, lower specificity, and lower accuracy in the prediction of the benign or malignant nature of nodules. In the group with no calcification, US had a significantly greater accuracy than CT and combined US/CT. In the group with macrocalcification, especially in rim calcifications, adding CT to US resulted in greater sensitivity than US, and CT exhibited greater sensitivity and accuracy than US. Conclusion: US is superior to CT for the prediction of the benign or malignant nature of nodules in thyroid lesions according to calcification and CT is also currently not recommended as a routine imaging tool for thyroid nodules. However, the superior sensitivity and accuracy of CT in lesions with macrocalcification especially in rim calcifications may enable CT to play a complementary role in identifying benign and malignant nodules.

Percutaneous thermal microwave ablation of thyroid nodules

2014 ◽  
Vol 53 (04) ◽  
pp. 123-130 ◽  
Author(s):  
C. Happel ◽  
K. Heck ◽  
H. Ackermann ◽  
F. Grünwald ◽  
H. Korkusuz
Keyword(s):  
Functional Imaging ◽  
Work Experience ◽  
Thermal Ablation ◽  
Microwave Ablation ◽  
Thyroid Nodules ◽  
Minimal Invasive ◽  
Invasive Method ◽  
99Mtc Mibi ◽  
Benign Thyroid Nodules ◽  
Benign Thyroid

SummaryMicrowave ablation (MWA) is a new minimal invasive method for thermal ablation of benign thyroid nodules. In contrast to well-established radiofrequency ablation (RFA), MWA offers several advantages with similarly successful results. There has not been any use of functional imaging with 99mTc-per- technetate and 99mTc-MIBI-scans as a mere qualitative analysis of this imaging in the field of MWA in Europe until now. The aim of this study has been to demonstrate the feasibility of MWA as well as the applicability of functional imaging to verify effectiveness with a centerspecific score. Patients, methods: 11 patients (5 women, 6 men, average age 62.3 years) with 18 benign thyroid nodules were treated. MWA was operated under local anesthesia with a system working in a wavelength field of 902 to 928 MHz (Avecure MWG881, MedWaves, Inc. San Diego, CA). Pre- and postablative scans were controlled by two specialists in nuclear medicine with longtime work experience. Results: A center specific functional imaging score (CSFIS) was defined, a decrease of 1.4 points at an average was noticeable (range 1-3 points). In 66.7% (n = 12) of all nodules the score decreased by 1 point, 27.8% (n = 5) by 2 points and 5.6% (n = 1) by 3 points. The treatment was well tolerated and no severe complications were observed. Conclusion: The preliminary data suggests that MWA is an effective method to treat benign thyroid nodules. Functional imaging is a promising technique for early verification of effectiveness of thermal ablation.

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