scholarly journals Mouse Antibody of IgM Class is Prone to Non-Enzymatic Cleavage between CH1 and CH2 Domains

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Tomasz Klaus ◽  
Krystyna Stalińska ◽  
Dominik Czaplicki ◽  
Paweł Mak ◽  
Bozena Skupien-Rabian ◽  
...  
2018 ◽  
Author(s):  
Sarah Klass ◽  
Matthew J. Smith ◽  
Tahoe Fiala ◽  
Jessica Lee ◽  
Anthony Omole ◽  
...  

Herein, we describe a new series of fusion proteins that have been developed to self-assemble spontaneously into stable micelles that are 27 nm in diameter after enzymatic cleavage of a solubilizing protein tag. The sequences of the proteins are based on a human intrinsically disordered protein, which has been appended with a hydrophobic segment. The micelles were found to form across a broad range of pH, ionic strength, and temperature conditions, with critical micelle concentration (CMC) values below 1 µM being observed in some cases. The reported micelles were found to solubilize hydrophobic metal complexes and organic molecules, suggesting their potential suitability for catalysis and drug delivery applications.


2020 ◽  
Vol 109 ◽  
pp. 104754
Author(s):  
Kajsa Nilsson ◽  
Ahmed Abdelghani ◽  
Stephen Burleigh ◽  
Lene Buhelt Johansen ◽  
Helena Lindmark-Månsson ◽  
...  
Keyword(s):  

1963 ◽  
Vol 238 (4) ◽  
pp. 1441-1446
Author(s):  
Junichi Nomura ◽  
Yasutomi Nishizuka ◽  
Osamu Hayaishi
Keyword(s):  

1950 ◽  
Vol 186 (1) ◽  
pp. 287-296
Author(s):  
Francis. Binkley
Keyword(s):  

1957 ◽  
Vol 226 (1) ◽  
pp. 485-495 ◽  
Author(s):  
Hayato Kihara ◽  
Esmond E. Snell
Keyword(s):  

1967 ◽  
Vol 242 (5) ◽  
pp. 936-950
Author(s):  
Andrew Becker ◽  
Jerard Hurwitz
Keyword(s):  

1958 ◽  
Vol 233 (5) ◽  
pp. 1175-1178
Author(s):  
G.D. Kalyankar ◽  
Miyoshi Ikawa ◽  
Esmond E. Snell
Keyword(s):  

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