Faculty Opinions recommendation of Self-assembling multidomain peptide hydrogels: designed susceptibility to enzymatic cleavage allows enhanced cell migration and spreading.

2010 ◽  
Author(s):  
Melissa Starovasnik ◽  
Christopher Koth
Keyword(s):  
Cell Migration ◽  
Enzymatic Cleavage ◽  
Self Assembling ◽  
Peptide Hydrogels

scholarly journals Self-Assembling Multidomain Peptide Hydrogels: Designed Susceptibility to Enzymatic Cleavage Allows Enhanced Cell Migration and Spreading

2010 ◽  
Vol 132 (9) ◽  
pp. 3217-3223 ◽  
Author(s):  
Kerstin M. Galler ◽  
Lorenzo Aulisa ◽  
Katherine R. Regan ◽  
Rena N. D’Souza ◽  
Jeffrey D. Hartgerink
Keyword(s):  
Cell Migration ◽  
Enzymatic Cleavage ◽  
Self Assembling ◽  
Peptide Hydrogels

Self-Assembling Micelles Based on an Intrinsically Disordered Protein Domain

2018 ◽  
Author(s):  
Sarah Klass ◽  
Matthew J. Smith ◽  
Tahoe Fiala ◽  
Jessica Lee ◽  
Anthony Omole ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Fusion Proteins ◽  
Organic Molecules ◽  
Intrinsically Disordered Protein ◽  
Protein Domain ◽  
Enzymatic Cleavage ◽  
Intrinsically Disordered ◽  
Disordered Protein ◽  
Self Assembling ◽  
Protein Tag

Herein, we describe a new series of fusion proteins that have been developed to self-assemble spontaneously into stable micelles that are 27 nm in diameter after enzymatic cleavage of a solubilizing protein tag. The sequences of the proteins are based on a human intrinsically disordered protein, which has been appended with a hydrophobic segment. The micelles were found to form across a broad range of pH, ionic strength, and temperature conditions, with critical micelle concentration (CMC) values below 1 µM being observed in some cases. The reported micelles were found to solubilize hydrophobic metal complexes and organic molecules, suggesting their potential suitability for catalysis and drug delivery applications.

Self-assembling peptide hydrogels immobilized on silicon surfaces

2016 ◽  
Vol 69 ◽  
pp. 200-207 ◽  
Author(s):  
Stefano Franchi ◽  
Chiara Battocchio ◽  
Martina Galluzzi ◽  
Emanuele Navisse ◽  
Annj Zamuner ◽  
...  
Keyword(s):  
Silicon Surfaces ◽  
Self Assembling ◽  
Peptide Hydrogels

Synergistic effects of dual-presenting VEGF- and BDNF-mimetic peptide epitopes from self-assembling peptide hydrogels on peripheral nerve regeneration

Nanoscale ◽  
2019 ◽  
Vol 11 (42) ◽  
pp. 19943-19958 ◽  
Author(s):  
Jiaju Lu ◽  
Xiaoqing Yan ◽  
Xun Sun ◽  
Xuezhen Shen ◽  
Heyong Yin ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Synergistic Effects ◽  
Peripheral Nerve Regeneration ◽  
Mimetic Peptide ◽  
Peptide Epitopes ◽  
Self Assembling ◽  
Peptide Hydrogels

We developed the functionalized self-assembling peptide nanofiber hydrogel RAD/KLT/RGI that was dual-functionalized with VEGF- and BDNF-mimetic peptide epitopes for peripheral nerve regeneration.

scholarly journals Investigation of Cancer Cell Migration and Proliferation on Synthetic Extracellular Matrix Peptide Hydrogels

2020 ◽  
Vol 8 ◽  
Author(s):  
Zbigniev Balion ◽  
Emilija Sipailaite ◽  
Gabija Stasyte ◽  
Agne Vailionyte ◽  
Airina Mazetyte-Godiene ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Cell Migration ◽  
Cancer Cell ◽  
Cancer Cell Migration ◽  
Cell Migration And Proliferation ◽  
Peptide Hydrogels

scholarly journals Self-assembling peptide hydrogels functionalized with LN- and BDNF- mimicking epitopes synergistically enhance peripheral nerve regeneration

Theranostics ◽  
2020 ◽  
Vol 10 (18) ◽  
pp. 8227-8249
Author(s):  
Shuhui Yang ◽  
Chong Wang ◽  
Jinjin Zhu ◽  
Changfeng Lu ◽  
Haitao Li ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Peripheral Nerve Regeneration ◽  
Self Assembling ◽  
Peptide Hydrogels

Self-Assembling Peptide Hydrogels for 3D Microarrays

2020 ◽  
pp. 179-189
Author(s):  
Greta Bergamaschi ◽  
Alessandro Strada ◽  
Roberto Frigerio ◽  
Marina Cretich ◽  
Alessandro Gori
Keyword(s):  
Self Assembling ◽  
Peptide Hydrogels
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