Type 2 diabetes impacts colorectal adenoma detection in screening colonoscopy

Background. The association between celiac disease and colorectal neoplasia has been previously studied, but the question whether recently diagnosed celiac patients show an increased colorectal adenoma prevalence remains unanswered. Aims. To compare the prevalence of colorectal adenomas between adult patients with a recent diagnosis of celiac disease versus healthy controls. Materials and Methods. A retrospective case-control study was undertaken. Patients with a diagnosis of celiac disease at an age of 45 years or more who undertook colonoscopy six months before or six months after the initiation of a gluten-free diet were enrolled as cases. Asymptomatic subjects undertaking screening colonoscopy were recruited as controls in a 2 : 1 fashion. The prevalence of colorectal adenomas and the prevalence of advanced adenomas were compared between groups. Results. 57 celiac disease patients and 118 controls were enrolled. There was a greater prevalence of female patients among the celiac group, with no significant differences in terms of age. There were more obese patients among controls and a higher proportion of tabaquism among celiac patients. Adenoma prevalence was significantly higher among celiac patients (47.37% versus 27.97%, p=0.01). Advanced adenoma detection was not different between groups. Conclusion. Adult patients with a recent diagnosis of celiac disease have an increased prevalence of colorectal adenomas.

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Insulin Therapy and Colorectal Adenoma Risk Among Patients with Type 2 Diabetes Mellitus: A Case-Control Study in Korea

Diseases of the Colon & Rectum ◽

10.1007/s10350-007-9184-1 ◽

2008 ◽

Vol 51 (5) ◽

pp. 593-597 ◽

Cited By ~ 52

Author(s):

Yong Woo Chung ◽

Dong Soo Han ◽

Kwang Hyuk Park ◽

Chang Soo Eun ◽

Kyo-Sang Yoo ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Insulin Therapy ◽

Colorectal Adenoma ◽

Case Control Study ◽

Case Control ◽

Adenoma Risk ◽

Control Study

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Type 2 Diabetes Mellitus: The Impact on Colorectal Adenoma Risk in Women

The American Journal of Gastroenterology ◽

10.1111/j.1572-0241.2006.00651.x ◽

2006 ◽

Vol 101 (8) ◽

pp. 1866-1871 ◽

Cited By ~ 56

Author(s):

Jill E. Elwing ◽

Feng Gao ◽

Nicholas O. Davidson ◽

Dayna S. Early

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Colorectal Adenoma ◽

The Impact ◽

Adenoma Risk

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S0301 Impact of Type 2 Diabetes Mellitus on Colorectal Adenoma-Carcinoma Progression: Which Metabolic Factors Play a Role?

The American Journal of Gastroenterology ◽

10.14309/01.ajg.0000703252.41684.3c ◽

2020 ◽

Vol 115 (1) ◽

pp. S147-S147

Author(s):

Kenneth Chow ◽

Lorenzo F. Ottaviano ◽

Joseph F. Lacomb ◽

Ying Yi Zhang ◽

Dimitri Joseph ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Colorectal Adenoma ◽

Metabolic Factors

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Effect of Obesity and Demographic Factors on Advanced Adenoma Detection Rate Among Type 2 Diabetes Mellitus Patients

The American Journal of Gastroenterology ◽

10.14309/00000434-201410002-02337 ◽

2014 ◽

Vol 109 ◽

pp. S679-S680

Author(s):

Deepanshu Jain ◽

Jorge Uribe

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Detection Rate ◽

Demographic Factors ◽

Adenoma Detection Rate ◽

Advanced Adenoma ◽

Adenoma Detection

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Impact of type 2 diabetes on adenoma detection in screening colonoscopies performed in disparate populations

World Journal of Clinical Cases ◽

10.12998/wjcc.v9.i11.2433 ◽

2021 ◽

Vol 9 (11) ◽

pp. 2433-2445

Author(s):

Dimitri F Joseph ◽

Ellen Li ◽

Samuel L Stanley III ◽

Yi-Cong Zhu ◽

Xiao-Ning Li ◽

...

Keyword(s):

Type 2 Diabetes ◽

Adenoma Detection

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THE IMPACT OF COLORECTAL CHROMENDOSCOPY WITH ENHANCED MUCOSAL IMAGING ON ADENOMA MISS RATE IN SCREENING COLONOSCOPY

Arquivos de Gastroenterologia ◽

10.1590/s0004-2803.202100000-82 ◽

2021 ◽

Vol 58 (4) ◽

pp. 450-455

Author(s):

Bruna Suelen Raymundo LUZ ◽

Juliana Carneiro Cabral Dourado CANTERAS ◽

Karen de Carvalho GON ◽

Maria Luisa de Deus BATISTA ◽

Thomy Jun AHN ◽

...

Keyword(s):

Colorectal Adenoma ◽

Detection Rate ◽

Colorectal Neoplasia ◽

Screening Colonoscopy ◽

Neoplastic Lesion ◽

Adenoma Detection ◽

Incidence And Mortality ◽

Group 2 ◽

The Impact ◽

Group 1

ABSTRACT BACKGROUND: Colonoscopy is the gold standard for the diagnosis and treatment of adenomas. It is related with decreased colorectal cancer incidence and mortality. However, an important problem is missed colorectal adenoma. All efforts should be undertaken to reduce this rate. Enhancing imaging technologies including electronic chromoendoscopy and magnification has been increasingly adopted for improving the colorectal neoplasia detection rate and the detailed study of its surface, as well. I-scan images (Pentax, Tokyo, Japan) provides virtual chromoendoscopy in real-time during the examination to view the surface pattern, highlighting the microvasculature of the neoplastic lesion. The evidence on the impact of the use of I-scan on the colorectal adenoma detection rate is scarce. OBJECTIVE: To evaluate whether the use of I-scan has impact on the adenoma miss rate (AMR) of screening colonoscopy exams. METHODS: Observational and prospective study conducted by monitoring patients over 50 years undergoing colonoscopy. There were two groups: Group 1 - first inspection with standard high-definition white-light (HDWL) followed by a second inspection with I-scan 1; Group 2 - first inspection with I-scan 1 followed by a second inspection with standard HDWL. The primary outcome was the AMR from the first exam, calculated with the number of adenomas detected in the second exam, divided by the total number of adenomas detected in both exams. RESULTS: A total of 85 patients participated in the study. 14 were excluded, with a final sample of 71 patients, in the Group 1, 34 patients, and the Group 2, 37. A total of 58 adenomas were detected, 40 in the first inspection (20 in each group) and 18 in the second inspection in group 1. The overall AMR was higher for the Group 1 than the Group 2 (47.4% vs 0% P=0.0002). CONCLUSION: The use of I-scan 1 during colonoscopy exam reduces the AMR.

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