scholarly journals 3D reconstruction of coronary artery bifurcations from coronary angiography and optical coherence tomography: feasibility, validation, and reproducibility

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Wei Wu ◽  
Saurabhi Samant ◽  
Gijs de Zwart ◽  
Shijia Zhao ◽  
Behram Khan ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Coronary Artery ◽  
3D Reconstruction ◽  
Three Dimensional ◽  
Plaque Burden ◽  
Patient Specific ◽  
Optical Coherence ◽  
Micro Computed Tomography ◽  
Processing Times ◽  
Mean Differences

Abstract The three-dimensional (3D) representation of the bifurcation anatomy and disease burden is essential for better understanding of the anatomical complexity of bifurcation disease and planning of stenting strategies. We propose a novel methodology for 3D reconstruction of coronary artery bifurcations based on the integration of angiography, which provides the backbone of the bifurcation, with optical coherence tomography (OCT), which provides the vessel shape. Our methodology introduces several technical novelties to tackle the OCT frame misalignment, correct positioning of the OCT frames at the carina, lumen surface reconstruction, and merging of bifurcation lumens. The accuracy and reproducibility of the methodology were tested in n = 5 patient-specific silicone bifurcations compared to contrast-enhanced micro-computed tomography (µCT), which was used as reference. The feasibility and time-efficiency of the method were explored in n = 7 diseased patient bifurcations of varying anatomical complexity. The OCT-based reconstructed bifurcation models were found to have remarkably high agreement compared to the µCT reference models, yielding r2 values between 0.91 and 0.98 for the normalized lumen areas, and mean differences of 0.005 for lumen shape and 0.004 degrees for bifurcation angles. Likewise, the reproducibility of our methodology was remarkably high. Our methodology successfully reconstructed all the patient bifurcations yielding favorable processing times (average lumen reconstruction time < 60 min). Overall, our method is an easily applicable, time-efficient, and user-friendly tool that allows accurate and reproducible 3D reconstruction of coronary bifurcations. Our technique can be used in the clinical setting to provide information about the bifurcation anatomy and plaque burden, thereby enabling planning, education, and decision making on bifurcation stenting.

scholarly journals Three dimensional reconstruction of coronary artery stents from optical coherence tomography: experimental validation and clinical feasibility

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Wei Wu ◽  
Behram Khan ◽  
Mohammadali Sharzehee ◽  
Shijia Zhao ◽  
Saurabhi Samant ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Coronary Artery ◽  
Three Dimensional ◽  
Coronary Stents ◽  
Patient Specific ◽  
Optical Coherence ◽  
Micro Computed Tomography ◽  
Stent Deployment ◽  
Structural Morphology ◽  
Coronary Artery Stents

AbstractThe structural morphology of coronary stents (e.g. stent expansion, lumen scaffolding, strut apposition, tissue protrusion, side branch jailing, strut fracture), and the local hemodynamic environment after stent deployment are key determinants of procedural success and subsequent clinical outcomes. High-resolution intracoronary imaging has the potential to enable the geometrically accurate three-dimensional (3D) reconstruction of coronary stents. The aim of this work was to present a novel algorithm for 3D stent reconstruction of coronary artery stents based on optical coherence tomography (OCT) and angiography, and test experimentally its accuracy, reproducibility, clinical feasibility, and ability to perform computational fluid dynamics (CFD) studies. Our method has the following steps: 3D lumen reconstruction based on OCT and angiography, stent strut segmentation in OCT images, packaging, rotation and straightening of the segmented struts, planar unrolling of the segmented struts, planar stent wireframe reconstruction, rolling back of the planar stent wireframe to the 3D reconstructed lumen, and final stent volume reconstruction. We tested the accuracy and reproducibility of our method in stented patient-specific silicone models using micro-computed tomography (μCT) and stereoscopy as references. The clinical feasibility and CFD studies were performed in clinically stented coronary bifurcations. The experimental and clinical studies showed that our algorithm (1) can reproduce the complex spatial stent configuration with high precision and reproducibility, (2) is feasible in 3D reconstructing stents deployed in bifurcations, and (3) enables CFD studies to assess the local hemodynamic environment within the stent. Notably, the high accuracy of our algorithm was consistent across different stent designs and diameters. Our method coupled with patient-specific CFD studies can lay the ground for optimization of stenting procedures, patient-specific computational stenting simulations, and research and development of new stent scaffolds and stenting techniques.

Serial three-dimensional optical coherence tomography to assess contained coronary artery perforation

2015 ◽  
Vol 26 ◽  
pp. e71-e72
Author(s):  
Cheng Yee Goh ◽  
Umair Hayat ◽  
Vikas Thondapu ◽  
Nicolas Foin ◽  
Peter Barlis
Keyword(s):  
Optical Coherence Tomography ◽  
Coronary Artery ◽  
Three Dimensional ◽  
Optical Coherence ◽  
Coronary Artery Perforation

scholarly journals Combining IVUS and Optical Coherence Tomography for More Accurate Coronary Cap Thickness Quantification and Stress/Strain Calculations: A Patient-Specific Three-Dimensional Fluid-Structure Interaction Modeling Approach

2018 ◽  
Vol 140 (4) ◽  
Author(s):  
Xiaoya Guo ◽  
Don P. Giddens ◽  
David Molony ◽  
Chun Yang ◽  
Habib Samady ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Fluid Structure Interaction ◽  
Three Dimensional ◽  
Patient Specific ◽  
Data Sets ◽  
Optical Coherence ◽  
Stress Strain ◽  
Fluid Structure ◽  
Structure Interaction ◽  
Modeling Approach

Accurate cap thickness and stress/strain quantifications are of fundamental importance for vulnerable plaque research. Virtual histology intravascular ultrasound (VH-IVUS) sets cap thickness to zero when cap is under resolution limit and IVUS does not see it. An innovative modeling approach combining IVUS and optical coherence tomography (OCT) is introduced for cap thickness quantification and more accurate cap stress/strain calculations. In vivo IVUS and OCT coronary plaque data were acquired with informed consent obtained. IVUS and OCT images were merged to form the IVUS + OCT data set, with biplane angiography providing three-dimensional (3D) vessel curvature. For components where VH-IVUS set zero cap thickness (i.e., no cap), a cap was added with minimum cap thickness set as 50 and 180 μm to generate IVUS50 and IVUS180 data sets for model construction, respectively. 3D fluid–structure interaction (FSI) models based on IVUS + OCT, IVUS50, and IVUS180 data sets were constructed to investigate cap thickness impact on stress/strain calculations. Compared to IVUS + OCT, IVUS50 underestimated mean cap thickness (27 slices) by 34.5%, overestimated mean cap stress by 45.8%, (96.4 versus 66.1 kPa). IVUS50 maximum cap stress was 59.2% higher than that from IVUS + OCT model (564.2 versus 354.5 kPa). Differences between IVUS and IVUS + OCT models for cap strain and flow shear stress (FSS) were modest (cap strain <12%; FSS <6%). IVUS + OCT data and models could provide more accurate cap thickness and stress/strain calculations which will serve as basis for further plaque investigations.

scholarly journals 3D Reconstruction of Coronary Artery Stents From Optical Coherence Tomography: Experimental Validation and Clinical Feasibility

2021 ◽  
Author(s):  
Wei Wu ◽  
Khan Behram A. ◽  
Mohammadali Sharzehee ◽  
Shijia Zhao ◽  
Saurabhi Samant ◽  
...  
Keyword(s):  
Coronary Artery ◽  
3D Reconstruction ◽  
Coronary Arteries ◽  
Side Branch ◽  
Patient Specific ◽  
Micro Computed Tomography ◽  
Stent Deployment ◽  
Structural Morphology ◽  
Stent Strut ◽  
Coronary Artery Stents

Abstract The structural morphology of stents (e.g. expansion, lumen scaffolding, strut apposition, tissue protrusion, side branch jailing, strut fracture), and the local hemodynamic environment after stent deployment in coronary arteries are key determinants of procedural success and subsequent clinical outcomes. High-resolution intracoronary imaging has the potential to enable the geometrically correct 3D reconstruction of coronary stents. The aim of this work was to present a novel algorithm for 3D stent reconstruction of coronary artery stents by OCT and angiography, and test experimentally its accuracy, reproducibility, clinical feasibility and ability to perform CFD studies. Our method has the following steps: 3D lumen reconstruction by OCT and angiography, stent strut segmentation on OCT images, packaging, rotation and straightening of the segmented struts, and planar unrolling of the segmented struts, planar stent wireframe reconstruction, rolling back of the planar stent wireframe to the 3D reconstructed lumen, and stent volume reconstruction. We tested the accuracy and reproducibility of our method in stented patient-specific silicone models using micro computed tomography and stereoscopy as reference. The clinical feasibility and CFD studies were performed in clinically stented coronary bifurcations. Our experimental and clinical studies showed that our proposed algorithm can reproduce the complex stent configuration in space with high precision and reproducibility. Furthermore, our studies showed that the algorithm is feasible in clinical cases with stents deployed in diseased, bifurcated coronary arteries, enabling CFD studies to assess the hemodynamic environment. Notably, the high accuracy of our algorithm was consistent across different stent designs and diameters. Our method coupled with patient-specific CFD studies can facilitate stenting optimization, training in stenting techniques, and stent research and development.

Sign in / Sign up

Export Citation Format

Share Document