scholarly journals Altered amygdala-based functional connectivity in individuals with attenuated psychosis syndrome and first-episode schizophrenia

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Woo-Sung Kim ◽  
Guangfan Shen ◽  
Congcong Liu ◽  
Nam-In Kang ◽  
Keon-Hak Lee ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Negative Relationship ◽  
First Episode ◽  
Frontal Pole ◽  
Resting State Functional Connectivity ◽  
Significant Group ◽  
Attenuated Psychosis Syndrome ◽  
The Right ◽  
First Episode Schizophrenia

Abstract Altered resting-state functional connectivity (FC) of the amygdala (AMY) has been demonstrated to be implicated in schizophrenia (SZ) and attenuated psychosis syndrome (APS). Specifically, no prior work has investigated FC in individuals with APS using subregions of the AMY as seed regions of interest. The present study examined AMY subregion-based FC in individuals with APS and first-episode schizophrenia (FES) and healthy controls (HCs). The resting state FC maps of the three AMY subregions were computed and compared across the three groups. Correlation analysis was also performed to examine the relationship between the Z-values of regions showing significant group differences and symptom rating scores. Individuals with APS showed hyperconnectivity between the right centromedial AMY (CMA) and left frontal pole cortex (FPC) and between the laterobasal AMY and brain stem and right inferior lateral occipital cortex compared to HCs. Patients with FES showed hyperconnectivity between the right superficial AMY and left occipital pole cortex and between the left CMA and left thalamus compared to the APS and HCs respectively. A negative relationship was observed between the connectivity strength of the CMA with the FPC and negative-others score of the Brief Core Schema Scales in the APS group. We observed different altered FC with subregions of the AMY in individuals with APS and FES compared to HCs. These results shed light on the pathogenetic mechanisms underpinning the development of APS and SZ.

Altered habenula resting state functional connectivity in deprived veteran tobacco smokers: A pilot study

2020 ◽  
Vol 84 (1) ◽  
pp. 21-34
Author(s):  
Cassandra Jennings ◽  
Savannah Gosnell ◽  
Kaylah N. Curtis ◽  
Thomas Kosten ◽  
Ramiro Salas
Keyword(s):  
Pilot Study ◽  
Functional Connectivity ◽  
Tobacco Smoking ◽  
Resting State ◽  
Nicotine Withdrawal ◽  
Frontal Pole ◽  
Resting State Functional Connectivity ◽  
Tobacco Withdrawal ◽  
Lingual Gyrus ◽  
The Right

This study aimed to examine habenular resting state functional connectivity (RSFC) abnormalities in tobacco-smoking veterans. The authors explored RSFC in sated smokers (n = 3D 18), overnight deprived smokers (n = 3D 13), and nonsmoker controls (n = 3D 26). Seed-to-voxel analysis was used to explore RSFC in the habenula. Compared to sated smokers, deprived smokers demonstrated higher RSFC between the right habenula and two clusters of voxels: one in the right fusiform gyrus, and one in the left lingual gyrus. To study nicotine withdrawal, the authors used the Shiffman-Jarvik Withdrawal Questionnaire (SJWQ) score as a regressor and found higher RSFC between the right habenula and the left frontal pole in deprived compared to sated smokers. Right habenula RSFC distinguished between sated and deprived smokers and differentiated between sated and deprived smokers when using SJWQ as a regressor, suggesting a habenular role in tobacco withdrawal.

Aberrant Resting-State Functional Connectivity of the Globus Pallidus Subregions in First-Episode Schizophrenia

2021 ◽  
Vol 89 (9) ◽  
pp. S322
Author(s):  
Wei Qi ◽  
Zhenfu Wen ◽  
Jingyun Chen ◽  
Jijun Wang ◽  
Mohammed Milad ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Globus Pallidus ◽  
Resting State ◽  
First Episode ◽  
Resting State Functional Connectivity ◽  
First Episode Schizophrenia

scholarly journals SU101. Altered Resting-State Functional Connectivity of Striatum in First-Episode Schizophrenia

2017 ◽  
Vol 43 (suppl_1) ◽  
pp. S197-S198
Author(s):  
Yi Wang ◽  
Karen S. Y. Hung ◽  
Michelle Y. Deng ◽  
Simon S. Y. Lui ◽  
Joe C. Y. Lee ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
First Episode ◽  
Resting State Functional Connectivity ◽  
First Episode Schizophrenia

Altered resting-state functional connectivity of the insula in individuals with clinical high-risk and patients with first-episode schizophrenia

2019 ◽  
Vol 282 ◽  
pp. 112608
Author(s):  
Xian-Bin Li ◽  
Lu-Bin Wang ◽  
Yan-Bing Xiong ◽  
Qi-Jing Bo ◽  
Fan He ◽  
...  
Keyword(s):  
High Risk ◽  
Functional Connectivity ◽  
Resting State ◽  
First Episode ◽  
Clinical High Risk ◽  
Resting State Functional Connectivity ◽  
First Episode Schizophrenia

scholarly journals Examining resting-state functional connectivity in first-episode schizophrenia with 7T fMRI and MEG

2019 ◽  
Vol 24 ◽  
pp. 101959 ◽  
Author(s):  
Kristin K. Lottman ◽  
Timothy J. Gawne ◽  
Nina V. Kraguljac ◽  
Jeffrey F. Killen ◽  
Meredith A. Reid ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
First Episode ◽  
Resting State Functional Connectivity ◽  
First Episode Schizophrenia ◽  
7T Fmri

Dissociation of fractional anisotropy and resting-state functional connectivity alterations in antipsychotic-naive first-episode schizophrenia

2019 ◽  
Vol 204 ◽  
pp. 230-237
Author(s):  
Jieke Liu ◽  
Li Yao ◽  
Wenjing Zhang ◽  
Wei Deng ◽  
Yuan Xiao ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Fractional Anisotropy ◽  
Resting State ◽  
First Episode ◽  
Resting State Functional Connectivity ◽  
First Episode Schizophrenia

Aberrant resting-state functional connectivity of salience network in first-episode schizophrenia

2019 ◽  
Vol 14 (5) ◽  
pp. 1350-1360 ◽  
Author(s):  
Huan Huang ◽  
Zeng Botao ◽  
Yuchao Jiang ◽  
Yingying Tang ◽  
Tianhong Zhang ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
First Episode ◽  
Salience Network ◽  
Resting State Functional Connectivity ◽  
First Episode Schizophrenia

Resting-state Functional Connectivity of the Right Temporoparietal Junction Relates to Belief Updating and Reorienting during Spatial Attention

2020 ◽  
Vol 32 (6) ◽  
pp. 1130-1141
Author(s):  
Anne-Sophie Käsbauer ◽  
Paola Mengotti ◽  
Gereon R. Fink ◽  
Simone Vossel
Keyword(s):  
Functional Connectivity ◽  
Cognitive Processing ◽  
Resting State ◽  
Prior Information ◽  
Dependent Manner ◽  
Resting State Functional Connectivity ◽  
Belief Updating ◽  
Temporoparietal Junction ◽  
Right Temporoparietal Junction ◽  
The Right

Although multiple studies characterized the resting-state functional connectivity (rsFC) of the right temporoparietal junction (rTPJ), little is known about the link between rTPJ rsFC and cognitive functions. Given a putative involvement of rTPJ in both reorienting of attention and the updating of probabilistic beliefs, this study characterized the relationship between rsFC of rTPJ with dorsal and ventral attention systems and these two cognitive processes. Twenty-three healthy young participants performed a modified location-cueing paradigm with true and false prior information about the percentage of cue validity to assess belief updating and attentional reorienting. Resting-state fMRI was recorded before and after the task. Seed-based correlation analysis was employed, and correlations of each behavioral parameter with rsFC before the task, as well as with changes in rsFC after the task, were assessed in an ROI-based approach. Weaker rsFC between rTPJ and right intraparietal sulcus before the task was associated with relatively faster updating of the belief that the cue will be valid after false prior information. Moreover, relatively faster belief updating, as well as faster reorienting, were related to an increase in the interhemispheric rsFC between rTPJ and left TPJ after the task. These findings are in line with task-based connectivity studies on related attentional functions and extend results from stroke patients demonstrating the importance of interhemispheric parietal interactions for behavioral performance. The present results not only highlight the essential role of parietal rsFC for attentional functions but also suggest that cognitive processing during a task changes connectivity patterns in a performance-dependent manner.

scholarly journals Resting State Functional Connectivity Predicts Future Changes in Sedentary Behavior

2021 ◽  
Author(s):  
Timothy P. Morris ◽  
Aaron Kucyi ◽  
Sheeba Arnold Anteraper ◽  
Maiya Rachel Geddes ◽  
Alfonso Nieto-Castañon ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Exercise Intervention ◽  
Supplementary Motor Area ◽  
Anterior Insula ◽  
Motor Area ◽  
Anterior Cingulate ◽  
Sedentary Behaviors ◽  
Resting State Functional Connectivity ◽  
The Right

AbstractInformation about a person’s available energy resources is integrated in daily behavioral choices that weigh motor costs against expected rewards. It has been posited that humans have an innate attraction towards effort minimization and that executive control is required to overcome this prepotent disposition. With sedentary behaviors increasing at the cost of millions of dollars spent in health care and productivity losses due to physical inactivity-related deaths, understanding the predictors of sedentary behaviors will improve future intervention development and precision medicine approaches. In 64 healthy older adults participating in a 6-month aerobic exercise intervention, we use neuroimaging (resting state functional connectivity), baseline measures of executive function and accelerometer measures of time spent sedentary to predict future changes in objectively measured time spent sedentary in daily life. Using cross-validation and bootstrap resampling, our results demonstrate that functional connectivity between 1) the anterior cingulate cortex and the supplementary motor area and 2) the right anterior insula and the left temporoparietal/temporooccipital junction, predict changes in time spent sedentary, whereas baseline cognitive, behavioral and demographic measures do not. Previous research has shown activation in and between the anterior cingulate and supplementary motor area as well as in the right anterior insula during effort avoidance and tasks that integrate motor costs and reward benefits in effort-based decision making. Our results add important knowledge toward understanding mechanistic associations underlying complex sedentary behaviors.

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