scholarly journals Increased burst coding in deep layers of the ventral anterior cingulate cortex during neuropathic pain

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Fernando Kasanetz ◽  
Thomas Nevian
Keyword(s):  
Neuropathic Pain ◽  
Anterior Cingulate Cortex ◽  
Neuronal Excitability ◽  
Treatment Strategies ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Electrophysiological Recordings ◽  
Deep Layers ◽  
Noxious Stimuli

AbstractNeuropathic pain induces changes in neuronal excitability and synaptic connectivity in deep layers of the anterior cingulate cortex (ACC) that play a central role in the sensory, emotional and affective consequences of the disease. However, how this impacts ACC in vivo activity is not completely understood. Using a mouse model, we found that neuropathic pain caused an increase in ACC in vivo activity, as measured by the indirect activity marker c-Fos and juxtacellular electrophysiological recordings. The enhanced firing rate of ACC neurons in lesioned animals was based on a change in the firing pattern towards bursting activity. Despite the proportion of ACC neurons recruited by noxious stimuli was unchanged during neuropathic pain, responses to noxious stimuli were characterized by increased bursting. Thus, this change in coding pattern may have important implications for the processing of nociceptive information in the ACC and could be of great interest to guide the search for new treatment strategies for chronic pain.

The Increased In Vivo Firing of Pyramidal Cells But not Interneurons in the Anterior Cingulate Cortex After Neuropathic Pain

2021 ◽  
Author(s):  
Da-Yu Zhu ◽  
Ting-Ting Cao ◽  
Hong-Wei Fan ◽  
Ming-Zhe Zhang ◽  
Hao-Kai Duan ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Neuropathic Pain ◽  
Firing Rate ◽  
Anterior Cingulate Cortex ◽  
Pyramidal Cells ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
High Frequency Stimulation ◽  
Nociceptive Information

Abstract Chronic pain damages the balance between excitation and inhibition in the sensory cortex. It has been confirmed that the activity of cortical glutamatergic pyramidal cells increases after chronic pain. However, whether the activity of inhibitory interneurons synchronized changed remains obscure, especially in in vivo conditions. In the present study, we checked the firing rate of pyramidal cells and interneurons in the anterior cingulate cortex, a main cortical area for the regulation of nociceptive information in mice with spared nerve injury by using in vivo multi-channel recording system. We found that the firing rate of pyramidal cells but not interneurons increased in the ACC, which is further confirmed by the increased FOS expression in pyramidal cells but not interneurons, in mice with neuropathic pain. Selectively high frequency stimulation of the ACC nociceptive afferent fibers only potentiated the activity of pyramidal cells either. Our results thus suggest that the increased activity of pyramidal cells contributes to the damaged E/I balance in the ACC and is important for the pain hypersensitivity in mice with neuropathic pain.

Role for NMDA receptors in visceral nociceptive transmission in the anterior cingulate cortex of viscerally hypersensitive rats

2008 ◽  
Vol 294 (4) ◽  
pp. G918-G927 ◽  
Author(s):  
Xiaoyin Wu ◽  
Jun Gao ◽  
Jin Yan ◽  
Jing Fan ◽  
Chung Owyang ◽  
...  
Keyword(s):  
Nmda Receptors ◽  
Receptor Antagonist ◽  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Neuronal Firing ◽  
Anterior Cingulate ◽  
High Dose ◽  
Glutamatergic Transmission ◽  
Reverse Microdialysis

We have identified colorectal distension (CRD)-responsive neurons in the anterior cingulate cortex (ACC) and demonstrated that persistence of a heightened visceral afferent nociceptive input to the ACC induces ACC sensitization. In the present study, we confirmed that rostral ACC neurons of sensitized rats [induced by chicken egg albumin (EA)] exhibit enhanced spike responses to CRD. Simultaneous in vivo recording and reverse microdialysis of single ACC neurons showed that a low dose of glutamate (50 μM) did not change basal ACC neuronal firing in normal rats but increased ACC neuronal firing in EA rats from 18 ± 2 to 32 ± 3.8 impulses/10 s. A high dose of glutamate (500 μM) produced 1.95-fold and a 4.27-fold increases of ACC neuronal firing in sham-treated rats and in EA rats, respectively, suggesting enhanced glutamatergic transmission in the ACC neurons of EA rats. Reverse microdialysis of the 3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)/kainite receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX; 10 μM) reduced basal and abolished CRD-induced ACC neuronal firing in normal rats. In contrast, microdialysis of N-methyl-d-aspartate (NMDA) receptor antagonist AP5 had no effect on ACC neuronal firing in normal rats. However, AP5 produced 86% inhibition of ACC neuronal firing evoked by 50 mmHg CRD in the EA rats. In conclusion, ACC nociceptive transmissions are mediated by glutamate AMPA receptors in the control rats. ACC responses to CRD are enhanced in viscerally hypersensitive rats. The enhancement of excitatory glutamatergic transmission in the ACC appears to mediate this response. Furthermore, NMDA receptors mediate ACC synaptic responses after the induction of visceral hypersensitivity.

scholarly journals A transcriptomic analysis of neuropathic pain in the anterior cingulate cortex after nerve injury

Bioengineered ◽  
2022 ◽  
Vol 13 (2) ◽  
pp. 2058-2075
Author(s):  
Yu Zhang ◽  
Shiwei Jiang ◽  
Fei Liao ◽  
Zhifeng Huang ◽  
Xin Yang ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Anterior Cingulate Cortex ◽  
Nerve Injury ◽  
Cingulate Cortex ◽  
Transcriptomic Analysis ◽  
Anterior Cingulate

In vivo evidence for early neurodevelopmental anomaly of the anterior cingulate cortex in bipolar disorder

2007 ◽  
Vol 116 (6) ◽  
pp. 467-472 ◽  
Author(s):  
A. Fornito ◽  
G. S. Malhi ◽  
J. Lagopoulos ◽  
B. Ivanovski ◽  
S. J. Wood ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Anterior Cingulate

scholarly journals Metabolite activity in the anterior cingulate cortex during a painful stimulus using functional MRS

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
J. Archibald ◽  
E. L. MacMillan ◽  
C. Graf ◽  
P. Kozlowski ◽  
C. Laule ◽  
...  
Keyword(s):  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Noxious Stimulation ◽  
Resonance Spectroscopy ◽  
Large Effect Size ◽  
Brain Responses ◽  
Pain Outcomes ◽  
Healthy Participants

Abstract To understand neurochemical brain responses to pain, proton magnetic resonance spectroscopy (1H-MRS) is used in humans in vivo to examine various metabolites. Recent MRS investigations have adopted a functional approach, where acquisitions of MRS are performed over time to track task-related changes. Previous studies suggest glutamate is of primary interest, as it may play a role during cortical processing of noxious stimuli. The objective of this study was to examine the metabolic effect (i.e., glutamate) in the anterior cingulate cortex during noxious stimulation using fMRS. The analysis addressed changes in glutamate and glutamate + glutamine (Glx) associated with the onset of pain, and the degree by which fluctuations in metabolites corresponded with continuous pain outcomes. Results suggest healthy participants undergoing tonic noxious stimulation demonstrated increased concentrations of glutamate and Glx at the onset of pain. Subsequent reports of pain were not accompanied by corresponding changes in glutamate of Glx concentrations. An exploratory analysis on sex revealed large effect size changes in glutamate at pain onset in female participants, compared with medium-sized effects in male participants. We propose a role for glutamate in the ACC related to the detection of a noxious stimulus.

Author response: Insular and anterior cingulate cortex deep stimulation for central neuropathic pain: Disassembling the percept of pain

Neurology ◽  
2020 ◽  
Vol 94 (16) ◽  
pp. 721-722
Author(s):  
Daniel Ciampi de Andrade ◽  
Ricardo Galhardoni ◽  
Valquíria Aparecida da Silva ◽  
Luís García-Larrea ◽  
Camila Dale ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Author Response ◽  
Central Neuropathic Pain

Expression of muscarinic M1 and M2 receptors in the anterior cingulate cortex associated with neuropathic pain

2010 ◽  
Vol 14 (9) ◽  
pp. 901-910 ◽  
Author(s):  
J. Manuel Ortega-Legaspi ◽  
Martha León-Olea ◽  
Patricia de Gortari ◽  
María Isabel Amaya ◽  
Ulises Coffeen ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Anterior Cingulate

Astrocytic activation in the anterior cingulate cortex is critical for sleep disorder under neuropathic pain

Synapse ◽  
2014 ◽  
Vol 68 (6) ◽  
pp. 235-247 ◽  
Author(s):  
Akira Yamashita ◽  
Asami Hamada ◽  
Yuki Suhara ◽  
Rui Kawabe ◽  
Makoto Yanase ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Sleep Disorder ◽  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Anterior Cingulate
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