scholarly journals Epithelial and stromal remodelling following femtosecond laser–assisted stromal lenticule addition keratoplasty (SLAK) for keratoconus

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mario Nubile ◽  
Niccolò Salgari ◽  
Jodhbir S. Mehta ◽  
Roberta Calienno ◽  
Emanuele Erroi ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Observational Study ◽  
Femtosecond Laser ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Anterior Segment ◽  
Corneal Epithelial ◽  
Cadaveric Donor ◽  
Epithelial Thickness ◽  
Corneal Epithelial Thickness

AbstractThe purpose of this study was to evaluate corneal epithelium and stromal remodelling with anterior segment optical coherence tomography in patients who have undergone stromal lenticule addition keratoplasty (SLAK) for advanced keratoconus. This was a prospective non-comparative observational study. Fifteen eyes of 15 patients with advanced keratoconus underwent implantation with a cadaveric, donor negative meniscus-shaped intrastromal lenticule, produced with a femtosecond laser, into a stromal pocket dissected in the recipient cornea at a depth of 120 μm. Simulated keratometry, central corneal thickness (CTT), corneal thinnest point (CTP), central epithelial thickness (CET), central and peripheral lenticule thickness, anterior and posterior stromal thickness were measured. Regional central corneal epithelial thickness (CET) and variations in the inner annular area (IAT) and outer annular area (OAT) were also analysed. All parameters were measured preoperatively and 1, 3, and 6 months postoperatively. The average anterior Sim-k decreased from 59.63 ± 7.58 preoperatively to 57.19 ± 6.33 D 6 months postoperatively. CCT, CTP, CET, and OAT increased and IAT decreased significantly after 1 month. All parameters appeared unchanged at 6-months except that of OAT that further increased. Lenticule thickness was stable. In conclusion we observed that SLAK reshapes the cornea by central flattening with stromal thickening and epithelial thickness restoration.

Effects of topical antiglaucomatous medications on central corneal epithelial thickness by anterior segment optical coherence tomography

2020 ◽  
Vol 30 (6) ◽  
pp. 1519-1524
Author(s):  
Emine Doğan ◽  
Burçin Köklü Çakır ◽  
Nilgün Özkan Aksoy ◽  
Erkan Celik ◽  
Ünal Erkorkmaz
Keyword(s):  
Optical Coherence Tomography ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Anterior Segment ◽  
Tear Film ◽  
Optical Coherence ◽  
Corneal Epithelial ◽  
Duration Of Therapy ◽  
Epithelial Thickness ◽  
Corneal Epithelial Thickness

Purpose: To evaluate the effect of topical antiglaucomatous medications on central corneal epithelial thickness measured by anterior segment optical coherence tomography. Materials and methods: A total of 153 eyes of 153 patients using topical antiglaucomatous medications and 110 eyes of 110 control subjects were enrolled. Glaucoma type, duration of therapy, the number of drugs, and drops/day were noted in the patient group. Patients and control subjects underwent ocular examinations including Schirmer test, slit lamp examination for tear film break-up time, and anterior segment optical coherence tomography for central corneal thickness and central corneal epithelial thickness. Central corneal epithelial thickness and other data were evaluated separately with regard to glaucoma type, duration of therapy, the number of drops, and drugs in the patient group. Results: The mean ages of the patients and controls were 60.1 ± 10.8 and 58.7 ± 11.2 years, respectively. The groups were similar with regard to mean age and gender (p = 0.058, p = 0.734, respectively). The median (interquartile range) central corneal thickness was 536 (54) µm in patients and 552 (53) µm in controls (p = 0.011). The median (interquartile range) central corneal epithelial thickness of patients and controls were 56 (4) µm and 60 (8) µm, respectively (p < 0.001). The median (interquartile range) tear film break-up time and Schirmer were 12 (6) s and 10 (8) mm in patients and 16 (2) s and 18 (4) mm in controls, respectively (p < 0.001, p < 0.001). In patient group, there was no significant difference in the median central corneal thickness, central corneal epithelial thickness, and tear film break-up time in terms of glaucoma type, duration of therapy, the number of drugs, and the number of daily drops. Only the median Schirmer test was found to be statistically lower in terms of number of daily eye drops (p = 0.039). Conclusion: Using topical antiglaucomatous medications seems to affect the central corneal epithelial thickness in glaucoma patients. Central corneal epithelial thickness was thinner in glaucoma patients than controls. Anterior segment optical coherence tomography might be helpful to evaluate the effect of antiglaucomatous medications on central corneal epithelial thickness during treatment.

Graft epithelial mapping following penetrating keratoplasty using anterior segment optical coherence tomography

2021 ◽  
Vol 2 (1) ◽  
pp. 20-24
Author(s):  
Shaimaa A Arfeen ◽  
◽  
Noha M Khalil ◽  
Ghada A Nassar ◽  
◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Graft Rejection ◽  
Allograft Rejection ◽  
Penetrating Keratoplasty ◽  
Thickness Distribution ◽  
Anterior Segment ◽  
Study Group ◽  
Corneal Epithelial ◽  
Epithelial Thickness ◽  
Corneal Epithelial Thickness

AIM: To evaluate the changes in corneal epithelial thickness in corneal grafts following penetrating keratoplasty (PK) using anterior segment optical coherence tomography (AS-OCT), and to determine the role of epithelial thickness mapping in the early detection of graft rejection. METHODS: This prospective comparative observational study included 20 patients (20 eyes) who underwent PK as study group and 16 patients (16 eyes) as control group. Corneal epithelial thickness mapping using AS-OCT was performed at 2wk, 1 and 3mo postoperatively. The parameters of epithelial thickness and distribution at the 3mo were compared to 16 patients (16 eyes) with allograft rejection following PK. RESULTS: There was significant decline in the superior, inferior, maximum, and minimum epithelial thickness values of the study group at 1mo compared to 2wk (P=0.0004, 0.0001, 0.0001, 0.04 respectively) with no significant differences at 3mo compared to 1mo (P=0.4, 0.1, 0.8) respectively. Percentage of reduction in epithelial thickness was significantly higher than that of stromal thickness at 1mo compared to 2wk (P=0.04). The epithelial thickness maps showed a similar pattern of epithelial thickness distribution in the study group and in the rejection group showing considerable corneal edema. However, the allograft rejection group showed irregular pattern of epithelial thickness distribution in patients showing relatively higher central corneal thickness (CCT) as measured by pachymetry map. CONCLUSION: Quantitative assessment of graft epithelial remodeling following PK shows early changes that contribute to significant corneal graft thickness changes. Changes in corneal epithelial thickness and pattern of distribution could be used as an indicator for corneal graft rejection.

Sign in / Sign up

Export Citation Format

Share Document