scholarly journals Clinical features, epidemiology, autoantibody status, HLA haplotypes and genetic mechanisms of type 1 diabetes mellitus among children in Qatar

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Basma Haris ◽  
Ikhlak Ahmed ◽  
Najeeb Syed ◽  
Hakeem Almabrazi ◽  
Saras Saraswathi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Clinical Features ◽  
Arab Population ◽  
Hla Dq ◽  
Genetic Mechanisms ◽  
Autoantibody Status ◽  
Hla Haplotypes

AbstractTo describe the clinical features, epidemiology, autoantibody status, HLA haplotypes and genetic mechanisms of type 1 diabetes mellitus (T1DM). Patients (0–18 years) with diabetes were recruited. Clinical data was collected, autoantibodies and c-peptide were measured. Whole Genome Sequencing was performed. Genomic data analysis was compared with the known genes linked with T1DM and HLA alleles were studied. 1096 patients had one or more antibody positivity. The incidence of T1DM in 2020 was 38.05 per 100,000 children and prevalence was 249.73. GADA was the most common autoantibody followed by IAA. Variants in GSTCD, SKAP2, SLC9B1, BANK1 were most prevalent. An association of HLA haplotypes DQA1*03:01:01G (OR = 2.46, p value = 0.011) and DQB1*03:02:01G (OR = 2.43, p value = 0.022) was identified. The incidence of T1DM in Qatar is the fourth highest in the world, IA2 autoantibody was the most specific with some patients only having ZnT8 or IA2 autoantibodies thus underlining the necessity of profiling all 4 autoantibodies. The genes associated with T1DM in the Arab population were different from those that are common in the Caucasian population. HLA-DQ was enriched in the Qatari patients suggesting that it can be considered a major risk factor at an early age.

scholarly journals Clinical features, Epidemiology, Autoantibody status, HLA Haplotypes and Genetic Mechanisms of Type 1 diabetes mellitus among Children in Qatar

2021 ◽  
Author(s):  
Basma Haris ◽  
Ikhlak Ahmed ◽  
Najeeb Syed ◽  
Hakeem Almabrazi ◽  
Saras Saraswathi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Clinical Features ◽  
P Value ◽  
Hla Dq ◽  
Genetic Mechanisms ◽  
Autoantibody Status ◽  
Hla Haplotypes

Abstract Aims - To describe the clinical features, epidemiology, autoantibody status, HLA haplotypes and genetic mechanisms of type 1 diabetes mellitus (T1DM). Methods - Patients (0–18 years) with diabetes were recruited. Clinical data was collected, autoantibodies and c-peptide were measured. Whole Genome Sequencing was performed. Genomic data analysis was compared with the known genes linked with T1DM and HLA alleles were studied. Results - 1096 patients had one or more antibody positivity. The incidence of T1DM in 2020 was 38.05 per 100,000 children and prevalence was 249.73. GAD65 was the most common autoantibody and IA2 was most specific. Variants in GSTCD, SKAP2, SLC9B1, BANK1 were most prevalent. An association of HLA haplotypes DQA1*03:01:01G (OR = 2.46, pvalue = 0.011) and DQB1*03:02:01G (OR = 2.43, p value = 0.022) was identified. Conclusions - In this first prospective study, IA2 autoantibody was the most specific, some patients only have ZnT8 or IA2 autoantibodies thus underlining the necessity of profiling all 4 antibodies. The genes associated with T1DM in the Arab population were different from those that are common in the Caucasian population. HLA-DQ was enriched in the Qatari patients suggesting that it can be considered a major risk factor at an early age.

Interleukin-12p40 gene (IL-12B) polymorphism and Type 1 diabetes mellitus in Japanese: Possible role in subjects without having high-risk HLA haplotypes

2006 ◽  
Vol 71 (2) ◽  
pp. 164-169 ◽  
Author(s):  
Jian Mei Yang ◽  
Shoichiro Nagasaka ◽  
Toshimitsu Yatagai ◽  
Tomoatsu Nakamura ◽  
Ikuyo Kusaka ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
High Risk ◽  
Type 1 Diabetes Mellitus ◽  
Hla Haplotypes

scholarly journals Shoulder Periarthritis and its Imaging Features in Patients with Type 1 Diabetes Mellitus

2017 ◽  
Vol 53 (04) ◽  
pp. 222-229
Author(s):  
Abhilash Nair ◽  
Devasenathipathy Kandasamy ◽  
Raju Sharma ◽  
HL Nag ◽  
Upiderpal Singh ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Clinical Features ◽  
External Rotation ◽  
Adhesive Capsulitis ◽  
Imaging Features ◽  
Limited Information ◽  
Limited Joint Mobility

ABSTRACT Aim: There is limited information on periarthritis/adhesive capsulitis of the shoulder (ACS) in patients with type-1-diabetes mellitus (T1D). We assessed the prevalence and characteristics of ACS in patients with type-1-diabetes mellitus. Methods: Consecutive 267 patients attending 'Diabetes of Young Clinic' were screened for ACS. Those with clinical features of ACS were further assessed by 'shoulder pain and disability index' (SPADI), radiograph and MRI of the shoulder. The average glycemic status (HbA1c) during preceding 2 years was assessed in patients with and without ACS. Controls were age and sex matched healthy subjects (1:1 ratio). Results: Sixteen of 267 patients (6.0%) with type-1-diabetes had clinical features of ACS, unlike none of the healthy controls (P < 0.001). Internal and external rotation of the shoulders was the most frequently restricted movements in ACS. Thickened coracohumeral ligament and axillary pouch obliteration was characteristic MRI feature, present in 80.0% in 73.3% cases, respectively. Though 14/16 type-1-diabetes patients with ACS were symptomatic, they never reported these complaints in diabetic clinic with the treating physicians. On regression analysis (odds ratio; 95% CI), duration of diabetes (1.1; 1.03-1.17, P < 0.01), retinopathy (3.6; 1.05-12.52, P = 0.04), and limited joint mobility (6.4; 1.88-21.95, P < 0.01) were independent predictors for presence of ACS in type-1-diabetes. The mean HbA1c and lipid levels were comparable in patients with or without ACS. Conclusions: Six percent of patients with type-1-diabetes had ACS, which can be detected on clinical screening and confirmed by imaging to help initiate early treatment.

scholarly journals HLA‐DQ genotype and biochemical characterization of anti‐transglutaminase 2 antibodies in patients with type 1 diabetes mellitus in Taiwan

2020 ◽  
Vol 34 (6) ◽  
pp. 8459-8474
Author(s):  
Yann‐Jinn Lee ◽  
Wei‐Hsin Ting ◽  
Yi‐Wen Yang ◽  
Cheng‐Jui Lin ◽  
Yu‐Ting Hsieh ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Biochemical Characterization ◽  
Transglutaminase 2 ◽  
Hla Dq

HLA haplotypes associated with type 1 diabetes mellitus in north indian children

2004 ◽  
Vol 65 (1) ◽  
pp. 47-53 ◽  
Author(s):  
Uma Kanga ◽  
Balu Vaidyanathan ◽  
Ritika Jaini ◽  
Puthezath S.N Menon ◽  
Narinder K Mehra
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Indian Children ◽  
Hla Haplotypes

scholarly journals Markers for hepatic autoimmune disorders in patients with type 1 diabetes mellitus

2014 ◽  
Vol 17 (1) ◽  
pp. 29-33
Author(s):  
Olga Sergeevna Derevyanko ◽  
Nadejda Sergeevna Dalantaeva ◽  
Olga Nikolaevna Ivanova ◽  
Nikolay Petrovich Goncharov ◽  
Tatiana Vasil'evna Nikonova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Autoimmune Hepatitis ◽  
Clinical Features ◽  
Autoimmune Disorders ◽  
Diagnostic Methods

Aim. To assess the occurrence of autoantibodies characteristic of autoimmune hepatitis in patients with type 1 diabetes mellitus (T1DM), and to analyze clinical features of positive subjects. Materials and Methods. . 84 patients (39 male, 45 female) with T1DM were subdivided into two groups and underwent biochemical, immunologic and instrumental examination. Results. Markers for hepatic autoimmune disorders were found to be highly prevalent in patients with T1DM, even in those asymptomatic according to clinical and instrumental diagnostic methods. Conclusion.  Our data suggests that T1DM patients are at higher risk of corresponding, though possibly asymptomatic autoimmune disorders.

Sign in / Sign up

Export Citation Format

Share Document