scholarly journals Using electrocochleography to detect sensory and neural damages in a gerbil model

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sebastiaan W. F. Meenderink ◽  
Xiaohui Lin ◽  
Wei Dong
Keyword(s):  
Otoacoustic Emissions ◽  
Round Window ◽  
Auditory Pathway ◽  
Distortion Product Otoacoustic Emissions ◽  
Treatment Intervention ◽  
Distortion Product ◽  
Neural Damage ◽  
Distortion Products ◽  
Appropriate Treatment ◽  
Distinct Level

AbstractHearing is one of the five sensory organs that allows us to interact with society and our environment. However, one in eight Americans suffers from sensorineural hearing loss that is great enough to adversely impact their daily life. There is an urgent need to identify what part/degree of the auditory pathway (sensory or neural) is compromised so that appropriate treatment/intervention can be implemented. Single- or two-tone evoked potentials, the electrocochleography (eCochG), were measured along the auditory pathway, i.e., at the round window and remotely at the vertex, with simultaneous recordings of ear canal distortion product otoacoustic emissions. Sensory (cochlear) and neural components in the (remote-) eCochG responses showed distinct level- and frequency-dependent features allowing to be differentiated from each other. Specifically, the distortion products in the (remote-)eCochGs can precisely localize the sensory damage showing that they are effective to determine the sensory or neural damage along the auditory pathway.

scholarly journals Reliability of Contralateral Suppression in Evoked Distortion Product Otoacoustic Emissions

2021 ◽  
Author(s):  
Ana Carolina dos Santos ◽  
Ludimila Labanca ◽  
Larissa Resende Assumpção ◽  
Patricia Cotta Mancini ◽  
Sirley Alves da Silva Carvalho ◽  
...  
Keyword(s):  
Otoacoustic Emissions ◽  
Auditory Pathway ◽  
Inhibitory Effect ◽  
Wilcoxon Test ◽  
Distortion Product Otoacoustic Emissions ◽  
Cochlear Function ◽  
Cross Sectional ◽  
Distortion Product ◽  
Clinical Applicability ◽  
Contralateral Suppression

Abstract Introduction Distortion product otoacoustic emissions (DPOAE) and their suppression may be considered useful in monitoring cochlear function and the efferent auditory pathway inhibitory effect. Nonetheless, the establishment of reliable parameters of response variations is of great importance. Objectives To verify the replicability of test and retest in the research of the inhibitory effect of the efferent pathway using contralateral suppressing stimulus during DPOAE recording for clinical applicability. Methods Cross-sectional study with 48 volunteers, aged 18 to 30 years, with normal audiometric thresholds. The procedures included were audiometric and immittance measures to overrule any conductive or sensorineural conditions and DPOAE recordings without and with contralateral suppression with a 60 dBHL white noise. Distortion product otoacoustic emissions amplitudes were analyzed and compared in both conditions with Wilcoxon test, and the Spearman correlation test was used to assess test-retest reliability. Results The comparative analysis showed differences between amplitudes in test and retest conditions only in 1,500 Hz for DPOAE measures with all other tested frequencies showing no differences, and no difference was observed in all recorded frequencies in the test and retest comparison for DPOAE suppression. The degree of correlation between test and retest of DPOAE amplitude was good at 6,000 Hz and strong (r > 0.880) at the other frequencies. For DPOAE with suppression, all frequencies presented strong correlation between test and retest: 1,500 Hz (r = 0.880), 2,000 Hz (r = 0.882), 3,000 Hz (r = 0.940), and 6,000 Hz (r = 0.957). Conclusions The study found good replicability in contralateral suppression of DPOAE with potential clinical applicability, and we recommend conducting the test from 2000Hz to higher frequencies for more reliable results.

Evaluation of Efferent Auditory System and Hearing Quality in Parkinson's Disease: Is the Difficulty in Speech Understanding in Complex Listening Conditions Related to Neural Degeneration or Aging?

2020 ◽  
pp. 1-9
Author(s):  
Nuriye Yıldırım Gökay ◽  
Bülent Gündüz ◽  
Fatih Söke ◽  
Recep Karamert
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Auditory System ◽  
Otoacoustic Emissions ◽  
Pure Tone ◽  
Pure Tone Audiometry ◽  
Auditory Pathway ◽  
Normal Hearing ◽  
System Function ◽  
Distortion Product

Purpose The effects of neurological diseases on the auditory system have been a notable issue for investigators because the auditory pathway is closely associated with neural systems. The purposes of this study are to evaluate the efferent auditory system function and hearing quality in Parkinson's disease (PD) and to compare the findings with age-matched individuals without PD to present a perspective on aging. Method The study included 35 individuals with PD (mean age of 48.50 ± 8.00 years) and 35 normal-hearing peers (mean age of 49 ± 10 years). The following tests were administered for all participants: the first section of the Speech, Spatial and Qualities of Hearing Scale; pure-tone audiometry, speech audiometry, tympanometry, and acoustic reflexes; and distortion product otoacoustic emissions (DPOAEs) and contralateral suppression of DPOAEs. SPSS Version 25 was used for statistical analyses, and values of p < .05 were considered statistically significant. Results There were no statistically significant differences in the pure-tone audiometry thresholds and DPOAE responses between the individuals with PD and their normal-hearing peers ( p = .732). However, statistically significant differences were found between the groups in suppression levels of DPOAEs and hearing quality ( p < .05). In addition, a statistically significant and positive correlation was found between the amount of suppression at some frequencies and the Speech, Spatial and Qualities of Hearing Scale scores. Conclusions This study indicates that medial olivocochlear efferent system function and the hearing quality of individuals with PD were affected adversely due to the results of PD pathophysiology on the hearing system. For optimal intervention and follow-up, tasks related to hearing quality in daily life can also be added to therapies for PD.

Relationship Between Distortion Product Otoacoustic Emissions and Hearing Loss

2006 ◽  
Vol 2 (1) ◽  
pp. 2-9
Author(s):  
Tiffany A. Johnson ◽  
Stephen T. Neely ◽  
Michael P. Gorga
Keyword(s):  
Hearing Loss ◽  
Otoacoustic Emissions ◽  
Distortion Product Otoacoustic Emissions ◽  
Distortion Product

Distortion product otoacoustic emissions upon ear canal pressurization

2013 ◽  
Vol 133 (4) ◽  
pp. EL331-EL337 ◽  
Author(s):  
Makram Zebian ◽  
Volker Schirkonyer ◽  
Johannes Hensel ◽  
Sven Vollbort ◽  
Thomas Fedtke ◽  
...  
Keyword(s):  
Otoacoustic Emissions ◽  
Distortion Product Otoacoustic Emissions ◽  
Ear Canal ◽  
Distortion Product

Dependence of distortion‐product otoacoustic emissions on primary levels in normal and impaired ears. II. Asymmetry in L1,L2 space

1995 ◽  
Vol 97 (4) ◽  
pp. 2359-2377 ◽  
Author(s):  
M. L. Whitehead ◽  
B. B. Stagner ◽  
M. J. McCoy ◽  
B. L. Lonsbury‐Martin ◽  
G. K. Martin
Keyword(s):  
Otoacoustic Emissions ◽  
Distortion Product Otoacoustic Emissions ◽  
Distortion Product
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