Bolus transit of upper esophageal sphincter on high-resolution impedance manometry study correlate with the laryngopharyngeal reflux symptoms

AbstractLaryngopharyngeal reflux symptom is a troublesome upper esophageal problem, and reflux symptom index (RSI) is commonly applied for the assessment of clinical severity. We investigated the relationship between the upper esophageal sphincter impedance integral (UESII) and RSI scores in this study. Totally 158 subjects with high-resolution esophageal impedance manometry (HRIM) with RSI questionnaire assessment were recruited. There are 57 (36.08%), 74 (46.84%), 21 (13.29%), and 6 (3.79%) patients were categorized as normal, ineffective esophageal motility disorder, absent contractility, and achalasia by HRIM examination, respectively. Subjects with RSI > 13 were noted to have lower UESII than others with RSI ≦ 13 (7363.14 ± 1085.58 vs. 11,833.75 ± 918.77 Ω s cm; P < 0.005). The ROC analysis yielded a UESII cutoff of < 2900 Ω s cm for the best prediction of subjects with RSI > 13 (P = 0.002). Both female gender and UESII cutoff of < 2900 Ω s cm were significant predictors of RSI > 13 in logistic regression analysis (OR = 3.84 and 2.83; P = 0.001 and 0.01; respectively). Lower UESII on HRIM study, indicating poor bolus transit of UES during saline swallows, is significantly associated with prominent laryngopharyngeal reflux symptoms scored by RSI score.

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Upper Esophageal Sphincter (UES) Abnormalities Assessed by High Resolution Esophageal Manometry (HREM) in Patients With Gastroesophageal Reflux Disease (GERD) and Laryngopharyngeal Reflux (LPR)

The American Journal of Gastroenterology ◽

10.14309/00000434-201510001-01697 ◽

2015 ◽

Vol 110 ◽

pp. S720-S721

Author(s):

Shamiq Zackria ◽

Rocio Lopez ◽

Prashanthi Thota

Keyword(s):

High Resolution ◽

Gastroesophageal Reflux Disease ◽

Gastroesophageal Reflux ◽

Reflux Disease ◽

Esophageal Manometry ◽

Laryngopharyngeal Reflux ◽

Upper Esophageal Sphincter ◽

Esophageal Sphincter

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The association between the reflux symptoms index and nasal symptoms among patients with non-allergic rhinitis

The Journal of Laryngology & Otology ◽

10.1017/s0022215120002492 ◽

2021 ◽

pp. 1-5

Author(s):

A W Hamizan ◽

Y Y Choo ◽

P V Loh ◽

N F Abd Talib ◽

M F Mohd Ramli ◽

...

Keyword(s):

Allergic Rhinitis ◽

Laryngopharyngeal Reflux ◽

Nasal Symptom ◽

Reflux Symptom ◽

Reflux Symptom Index ◽

Symptom Index ◽

Cross Sectional ◽

Nasal Symptoms ◽

Reflux Symptoms ◽

Non Allergic Rhinitis

Abstract Background Laryngopharyngeal reflux symptoms assessed with the reflux symptom index can overlap with non-allergic rhinitis symptoms. This study aims to explore the association between the reflux symptom index and nasal symptoms in non-allergic rhinitis patients. Methods A cross-sectional study was conducted on consecutive adults with non-allergic rhinitis. The reflux symptom index (score of more than 13 = laryngopharyngeal reflux) and nasal symptoms (categorised as mild (total score of 0–3), moderate (4–7) or severe (8–12)) were assessed. Results The study included 227 participants (aged 58.64 ± 12.39 years, 59.5 per cent female). The reflux symptom index scores increased with total nasal symptom scores (mild vs moderate vs severe, 8.61 ± 6.27 vs 12.94 ± 7.4 vs 16.40 ± 8.10; p < 0.01). Logistic regression indicated that laryngopharyngeal reflux is more likely in patients with severe nose block (odds ratio 5.47 (95 per cent confidence interval = 2.16–13.87); p < 0.01). Conclusion Laryngopharyngeal reflux symptoms are associated with nasal symptom severity, and nasal symptoms should be primarily treated. Those with predominant nose block and laryngopharyngeal reflux symptoms are more likely to have laryngopharyngeal reflux.

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