scholarly journals Characterization of the effects of cannabinoids on guinea-pig tracheal smooth muscle tone: role in the modulation of acetylcholine release from parasympathetic nerves

2000 ◽  
Vol 130 (7) ◽  
pp. 1720-1726 ◽  
Author(s):  
Lucia Spicuzza ◽  
El-Bdaoui Haddad ◽  
Mark Birrell ◽  
Andrea Ling ◽  
Deborah Clarke ◽  
...  
2003 ◽  
Vol 551 (3) ◽  
pp. 955-969 ◽  
Author(s):  
T. K Smith ◽  
G. R Oliver ◽  
G. W Hennig ◽  
D. M O'Shea ◽  
P. V. Berghe ◽  
...  

1986 ◽  
Vol 20 (6) ◽  
pp. 492-495 ◽  
Author(s):  
Vinod K Bhutani ◽  
Randy J Koslo ◽  
Thomas H Shaffer

2005 ◽  
Vol 24 (2) ◽  
pp. 95-97
Author(s):  
Gvozden Rosic ◽  
Zorica Lazic ◽  
Suzana Pantovic ◽  
Mirko Rosic

Histamine produces constriction of tracheal smooth muscle via H1 receptors, but it also decreases tracheal smooth muscle tone via H2 and H3 receptors. In addition, it has already been reported that phenylethylamine is competitive antagonist of histamine N-methyl-transferase (HMT), enzyme responsible for rapid inactivation of histamine. Our results suggest possibility that phenylethylamine as competitive antagonist of histamine N-methyl-transferase leads to potentiation of histamine induced constriction of isolated guinea-pig trachea, which could be consequence of decreased histamine methylation and subsequent histamine inactivation. At the same time, phenylethylamine had no direct effect on basal tone of intact isolated trachea rings, as well as on other mechanisms leading to increased responsiveness of guinea-pig tracheal smooth muscle (acetylcholine, KCl, electro stimulation).


1986 ◽  
Vol 64 (3) ◽  
pp. 351-363 ◽  
Author(s):  
Musa A. Haxhui ◽  
E.Chandler Deal ◽  
Matthew P. Norcia ◽  
Erik Van Lunteren ◽  
Jyoti Mitra ◽  
...  

1999 ◽  
Vol 88 (6) ◽  
pp. 1232-1238
Author(s):  
Michiaki Yamakage ◽  
Takashi Matsuzaki ◽  
Naoki Tsujiguchi ◽  
Tomohisa Mori ◽  
Akiyoshi Namiki

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