Effect of amphetamine on dopamine D2 receptor binding in the primate brain with the agonist ligand [11C]MNPA

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S646-S646
Author(s):  
Nicholas Seneca ◽  
Sjoerd Finnema ◽  
Masanori Ichise ◽  
Balazs Gulyas ◽  
Håkan Wikstrom ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Dopamine D2 ◽  
Primate Brain

Effect of amphetamine on dopamine D2 receptor binding in nonhuman primate brain: A comparison of the agonist radioligand [11C]MNPA and antagonist [11C]raclopride

Synapse ◽  
2006 ◽  
Vol 59 (5) ◽  
pp. 260-269 ◽  
Author(s):  
Nicholas Seneca ◽  
Sjoerd J. Finnema ◽  
Lars Farde ◽  
Balázs Gulyás ◽  
Håkan V. Wikström ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Nonhuman Primate ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Dopamine D2 ◽  
Primate Brain

2-Phenyl-4-(aminomethyl)imidazoles as Potential Antipsychotic Agents. Synthesis and Dopamine D2 Receptor Binding

1995 ◽  
Vol 38 (12) ◽  
pp. 2251-2255 ◽  
Author(s):  
Andrew Thurkauf ◽  
Alan Hutchison ◽  
John Peterson ◽  
Linda Cornfield ◽  
Robin Meade ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Antipsychotic Agents ◽  
Dopamine D2

Association between striatal and extrastriatal dopamine D2-receptor binding and social desirability

NeuroImage ◽  
2010 ◽  
Vol 50 (1) ◽  
pp. 323-328 ◽  
Author(s):  
Simon Cervenka ◽  
J. Petter Gustavsson ◽  
Christer Halldin ◽  
Lars Farde
Keyword(s):  
Social Desirability ◽  
Receptor Binding ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Dopamine D2

A Double-Injection Technique for in vivo Measurement of Dopamine D2-Receptor Density in Monkeys with 3-(2'-[18F] Fluoroethyl)Spiperone and Dynamic Positron Emission Tomography

1989 ◽  
Vol 9 (6) ◽  
pp. 850-858 ◽  
Author(s):  
Sung-Cheng Huang ◽  
Mark M. Bahn ◽  
Jorge R. Barrio ◽  
John M. Hoffman ◽  
Nagichettiar Satyamurthy ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Receptor Binding ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Emission Tomography ◽  
Injection Technique ◽  
Receptor Density ◽  
Dopamine D2 ◽  
Positron Emission ◽  
Kinetics Of

Dopamine D2-receptor density in striatum of monkey was measured with 3-(2'-[18F]fluoroethyl)spiperone (FESP) and dynamic positron emission tomography (PET), using a double-injection technique. A first bolus of high specific activity (SA) FESP (5 mCi; ≃ 1 Ci/μmol) was injected i.v.; 90 min later, a second bolus of lower SA FESP (5 mCi; ≃ 0.04 Ci/μmol) was injected. A dynamic PET study was performed to measure the kinetics of FESP in striatum over 180 min, and the metabolite-corrected concentration of FESP in plasma as a function of time was obtained from arterial blood samples. A nonlinear compartmental model that took into account the saturability of the receptor binding was used to describe the kinetics of FESP in striatum. Model parameters were estimated by regression with a constraint based on information about the equilibrium dissociation constant of the ligand–receptor binding. Dopamine D2-receptor density in striatum was estimated to be 25.9 ± 12.7 pmol/g in seven Macaca nemestrina monkeys. The method does not require the use of cerebellum as a reference tissue region and an estimate of dopamine D2-receptor density can be obtained from a single study.

REM sleep deprivation alters dopamine D2 receptor binding in the rat frontal cortex

1995 ◽  
Vol 52 (1) ◽  
pp. 43-48 ◽  
Author(s):  
Jeffery W. Brock ◽  
Anwar Hamdi ◽  
Keith Ross ◽  
Shorye Payne ◽  
Chandan Prasad
Keyword(s):  
Sleep Deprivation ◽  
Frontal Cortex ◽  
Receptor Binding ◽  
Rem Sleep ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Rem Sleep Deprivation ◽  
Dopamine D2 ◽  
Rat Frontal Cortex

Quantitative analysis of dopamine D2 receptor binding in human brain using PET with an agonist radioligand [11C]MNPA

NeuroImage ◽  
2008 ◽  
Vol 41 ◽  
pp. T134 ◽  
Author(s):  
Tatsui Otsuka ◽  
H. Ito ◽  
H. Takahashi ◽  
H. Takano ◽  
R. Arakawa ◽  
...  
Keyword(s):  
Quantitative Analysis ◽  
Human Brain ◽  
Receptor Binding ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Dopamine D2

Selective alterations of brain dopamine D2 receptor binding in cirrhotic patients: results of a 11C-N-methylspiperone PET study

2008 ◽  
Vol 23 (3) ◽  
pp. 265-274 ◽  
Author(s):  
Yuki Watanabe ◽  
Akinobu Kato ◽  
Kei Sawara ◽  
Roger F. Butterworth ◽  
Toshiaki Sasaki ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Brain Dopamine ◽  
Dopamine D2 ◽  
Cirrhotic Patients
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