Association of the angiotensin-converting enzyme (ACE) gene G2350A dimorphism with essential hypertension

The aim of the present study was to assess the effect of treatment with the angiotensin II receptor blocker telmisartan for 24 weeks on myocardial structure and function in patients with essential hypertension, and the relationship between this effect and the structural polymorphism of the angiotensin-converting enzyme (ACE) gene. Thirty-five patients with essential hypertension and left ventricular hypertrophy (LVH) without other associated morbidity were included in an open-label, non-comparative study. The patients were treated with telmisartan 40-80 mg once daily. In the final analysis, there were 29 patients who received the full course of treatment and were evaluated echocardiographically before and after treatment by the same blinded investigator, and myocardial structure and function were analysed. The myocardial mass of the left ventricle was determined in M-mode. Assessment of diastolic function of transmitral blood flow was performed using pulsed Doppler echocardiography. All patients were genotyped for insertion/deletion (I/D) polymorphism of the ACE gene. Telmisartan produced a significant reduction in left ventricular mass index from 140.4 ± 48.6 to 128.7 ± 40.6 g/m2 that was accompanied by an improvement in characteristics of diastolic function. The decrease in LVH was more significant in the ID genotype group than in the II and DD groups. Thus, prolonged treatment with telmisartan is accompanied by an improvement in myocardial structure, expressed as a reduction in left ventricular mass and function that is more marked in patients with ID genotype of the ACE gene.

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Association of essential hypertension in elderly Japanese with I/D polymorphism of the angiotensin-converting enzyme (ACE) gene

Journal of Human Genetics ◽

10.1007/s100380070019 ◽

2000 ◽

Vol 45 (5) ◽

pp. 294-298 ◽

Cited By ~ 11

Author(s):

K. Yoshida ◽

T. Ishigami ◽

I. Nakazawa ◽

A. Ohno ◽

K. Tamura ◽

...

Keyword(s):

Essential Hypertension ◽

Angiotensin Converting Enzyme ◽

Converting Enzyme ◽

Ace Gene ◽

Elderly Japanese

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Association between angiotensin converting enzyme gene polymorphism and essential hypertension: A systematic review and meta-analysis

Journal of the Renin-Angiotensin-Aldosterone System ◽

10.1177/1470320321995074 ◽

2021 ◽

Vol 22 (1) ◽

pp. 147032032199507

Author(s):

Mingyu Liu ◽

Jian Yi ◽

Wenwen Tang

Keyword(s):

Essential Hypertension ◽

Gene Polymorphism ◽

Angiotensin Converting Enzyme ◽

Asian Population ◽

Mixed Population ◽

Caucasian Population ◽

Converting Enzyme ◽

Ace Gene ◽

Regressive Model ◽

Allelic Model

Background: The current meta-analytic study explored the relation between ACE gene insertion/deletion (I/D), and the risk of EH by reviewing relevant trials so as to determine the association between Angiotensin Converting Enzyme (ACE) gene polymorphism and essential hypertension (EH) susceptibility. Methods: Relevant studies published before May 2019 were collected from the PubMed, Cochrane, Embase, CNKI, VANFUN, and VIP databases. Results: Fifty-seven studies involving a total of 32,862 patients were included. These studies found that ACE gene D allele was associated with higher EH susceptibility in allelic model, homozygote model, dominant model, and regressive model, and that Asian population with ACE gene D allele showed a higher EH susceptibility in all these models. Moreover, ACE gene D allele was found closely related to a higher EH susceptibility in the subgroups of HWE, NO HWE, Caucasian population, and Mixed population, with the majority being males in allelic model, homozygote model, and regressive model and the majority being females in allelic model. Conclusion: ACE gene D allele is associated with an overall higher EH susceptibility, which is confirmed in the subgroup analysis of Asian population, HWE, NO HWE, Caucasian population, and Mixed population.

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