scholarly journals Sequence dependence of electron-induced DNA strand breakage revealed by DNA nanoarrays

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Adrian Keller ◽  
Jenny Rackwitz ◽  
Emilie Cauët ◽  
Jacques Liévin ◽  
Thomas Körzdörfer ◽  
...  
Keyword(s):  
Sequence Dependence ◽  
Dna Nanoarrays ◽  
Strand Breakage ◽  
Dna Strand ◽  
Dna Strand Breakage

scholarly journals Synthesis and DNA Strand Breakage Activity of Some 1,4-Diazepines

2003 ◽  
Vol 51 (1) ◽  
pp. 27-31 ◽  
Author(s):  
Nobuko Mibu ◽  
Miho Yukawa ◽  
Nobuhiro Kashige ◽  
Yukiko Iwase ◽  
Yoshinobu Goto ◽  
...  
Keyword(s):  
Strand Breakage ◽  
Dna Strand ◽  
Dna Strand Breakage

Factors which affect DNA strand breakage in human leukocytes exposed to a tumor promoter, phorbol myristate acetate

1982 ◽  
Vol 60 (11) ◽  
pp. 1359-1366 ◽  
Author(s):  
H. C. Birnboim
Keyword(s):  
Hydrogen Peroxide ◽  
Dna Damage ◽  
Phorbol Myristate Acetate ◽  
Respiratory Burst ◽  
Superoxide Anion ◽  
Tumor Promoter ◽  
Myristate Acetate ◽  
Strand Breakage ◽  
Dna Strand ◽  
Dna Strand Breakage

We have recently reported that phorbol myristate acetate (PMA) induces extensive DNA strand break damage in human peripheral blood leukocytes. The mechanism of action involves superoxide anion and hydrogen peroxide which are generated by phagocytes during the "respiratory burst." In this report, we describe the effect of various inhibitors and scavengers on PMA-induced DNA damage. Azide and cyanide greatly increased the level of damage; sulfhydryl compounds (glutathione, cysteine, and cysteamine) and ascorbate markedly decreased the level of damage. Hydroxyl radical scavengers such as dimethyl sulfoxide (DMSO) and glycerol also decreased the level of damage but apparently did so by inhibiting the respiratory burst. Diethyldithiocarbamate (DDC) increased the level of DNA damage at low concentrations (<1 mM), but decreased DNA damage at ≥1 mM. The results are consistent with a mechanism involving superoxide anion and hydrogen peroxide, but the precise reaction (free radical or enzymatic) responsible for DNA strand breakage has not been determined. The PMA-stimulated phagocyte is an interesting model system for looking at "active oxygen" mediated DNA damage and factors which influence it.

Assessment of DNA strand breakage by comet assay in diabetic patients and the role of antioxidant supplementation

2001 ◽  
Vol 490 (2) ◽  
pp. 123-129 ◽  
Author(s):  
Semra Şardaş ◽  
Murat Yilmaz ◽  
Umut Öztok ◽  
Nuri Çakir ◽  
Ali Esat Karakaya
Keyword(s):  
Comet Assay ◽  
Diabetic Patients ◽  
Antioxidant Supplementation ◽  
Strand Breakage ◽  
Dna Strand ◽  
Dna Strand Breakage

Genetic effects of mercury contamination on aquatic snail populations: Allozyme genotypes and DNA strand breakage

2002 ◽  
Vol 21 (3) ◽  
pp. 584-589 ◽  
Author(s):  
Michael J. Benton ◽  
Michelle L. Malott ◽  
Jan Trybula ◽  
Deborah M. Dean ◽  
Sheldon I. Guttman
Keyword(s):  
Genetic Effects ◽  
Mercury Contamination ◽  
Strand Breakage ◽  
Dna Strand ◽  
Dna Strand Breakage

INHIBITION OF UV-INDUCED DNA STRAND BREAKAGE IN DICTYOSTELIUM DISCOIDEUM BY 2,4–DINITROPHENOL

1976 ◽  
Vol 24 (4) ◽  
pp. 331-336 ◽  
Author(s):  
A. Guialis ◽  
R. A. Deering
Keyword(s):  
Dictyostelium Discoideum ◽  
Strand Breakage ◽  
Dna Strand ◽  
Dna Strand Breakage

Thermal enhancement of dna strand breakage in mammalian cells treated with bleomycin

1979 ◽  
Vol 5 (9) ◽  
pp. 1487-1489 ◽  
Author(s):  
Raymond E Meyn ◽  
Peter M Corry ◽  
S.E FLetcher ◽  
Marie Demetriades
Keyword(s):  
Mammalian Cells ◽  
Thermal Enhancement ◽  
Strand Breakage ◽  
Dna Strand ◽  
Dna Strand Breakage
Sign in / Sign up

Export Citation Format

Share Document