scholarly journals Crystal structure of a COG4313 outer membrane channel

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Bert van den Berg ◽  
Satya Prathyusha Bhamidimarri ◽  
Mathias Winterhalter
Keyword(s):  
Crystal Structure ◽  
Outer Membrane ◽  
Membrane Channel ◽  
Outer Membrane Channel

scholarly journals Crystal Structure of the Open State of the Neisseria gonorrhoeae MtrE Outer Membrane Channel

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e97475 ◽  
Author(s):  
Hsiang-Ting Lei ◽  
Tsung-Han Chou ◽  
Chih-Chia Su ◽  
Jani Reddy Bolla ◽  
Nitin Kumar ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Neisseria Gonorrhoeae ◽  
Outer Membrane ◽  
Membrane Channel ◽  
Outer Membrane Channel

scholarly journals Crystal structure of theCampylobacter jejuniCmeC outer membrane channel

2014 ◽  
Vol 23 (7) ◽  
pp. 954-961 ◽  
Author(s):  
Chih-Chia Su ◽  
Abhijith Radhakrishnan ◽  
Nitin Kumar ◽  
Feng Long ◽  
Jani Reddy Bolla ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Outer Membrane ◽  
Membrane Channel ◽  
Outer Membrane Channel

Regulation of the mitochondrial outer membrane channel, VDAC

1987 ◽  
Vol 19 (4) ◽  
pp. 309-320 ◽  
Author(s):  
Marco Colombini
Keyword(s):  
Outer Membrane ◽  
Mitochondrial Outer Membrane ◽  
Membrane Channel ◽  
Outer Membrane Channel

scholarly journals The Salmonella Enteritidis TolC outer membrane channel is essential for egg white survival

2019 ◽  
Vol 98 (5) ◽  
pp. 2281-2289 ◽  
Author(s):  
R. Raspoet ◽  
V. Eeckhaut ◽  
K. Vermeulen ◽  
L. De Smet ◽  
Y. Wen ◽  
...  
Keyword(s):  
Outer Membrane ◽  
Salmonella Enteritidis ◽  
Egg White ◽  
Membrane Channel ◽  
Outer Membrane Channel

scholarly journals Metabolic shutdown in Escherichia coli cells lacking the outer membrane channel TolC

2010 ◽  
Vol 77 (3) ◽  
pp. 743-754 ◽  
Author(s):  
Girija Dhamdhere ◽  
Helen I. Zgurskaya
Keyword(s):  
Escherichia Coli ◽  
Outer Membrane ◽  
Membrane Channel ◽  
Escherichia Coli Cells ◽  
Outer Membrane Channel

scholarly journals An Excretory Function for the Escherichia coli Outer Membrane Pore TolC: Upregulation of marA and soxS Transcription and Rob Activity Due to Metabolites Accumulated in tolC Mutants

2009 ◽  
Vol 191 (16) ◽  
pp. 5283-5292 ◽  
Author(s):  
Judah L. Rosner ◽  
Robert G. Martin
Keyword(s):  
Escherichia Coli ◽  
Outer Membrane ◽  
Bile Salts ◽  
Efflux Pumps ◽  
Membrane Channel ◽  
Protein Activity ◽  
Membrane Pore ◽  
Excretory Function ◽  
Outer Membrane Channel ◽  
Transcriptional Fusions

ABSTRACT Efflux pumps function to rid bacteria of xenobiotics, including antibiotics, bile salts, and organic solvents. TolC, which forms an outer membrane channel, is an essential component of several efflux pumps in Escherichia coli. We asked whether TolC has a role during growth in the absence of xenobiotics. Because tolC transcription is activated by three paralogous activators, MarA, SoxS, and Rob, we examined the regulation of these activators in tolC mutants. Using transcriptional fusions, we detected significant upregulation of marRAB and soxS transcription and Rob protein activity in tolC mutants. Three mechanisms could be distinguished: (i) activation of marRAB transcription was independent of marRAB, soxR, and rob functions; (ii) activation of soxS transcription required SoxR, a sensor of oxidants; and (iii) Rob protein was activated posttranscriptionally. This mechanism is similar to the mechanisms of upregulation of marRAB, soxS, and Rob by treatment with certain phenolics, superoxides, and bile salts, respectively. The transcription of other marA/soxS/rob regulon promoters, including tolC itself, was also elevated in tolC mutants. We propose that TolC is involved in the efflux of certain cellular metabolites, not only xenobiotics. As these metabolites accumulate during growth, they trigger the upregulation of MarA, SoxS, and Rob, which in turn upregulate tolC and help rid the bacteria of these metabolites, thereby restoring homeostasis.

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