scholarly journals Two Genetic Variations in the IRF8 region are associated with Behçet’s disease in Han Chinese

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Yanni Jiang ◽  
Hong Wang ◽  
Hongsong Yu ◽  
Lin Li ◽  
Dengfeng Xu ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Genetic Variations ◽  
Han Chinese ◽  
Behcet's Disease

scholarly journals Genetic Variations of IL-12B, IL-12Rβ1, IL-12Rβ2 in Behcet's Disease and VKH Syndrome

PLoS ONE ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. e98373 ◽  
Author(s):  
Xinyu Li ◽  
Lin Bai ◽  
Jing Fang ◽  
Shengping Hou ◽  
Qingyun Zhou ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Genetic Variations ◽  
Behcet's Disease ◽  
Vkh Syndrome

Association ofERAP1Gene Polymorphisms With Behçet's Disease in Han Chinese

2015 ◽  
Vol 56 (10) ◽  
pp. 6029 ◽  
Author(s):  
Lijun Zhang ◽  
Hongsong Yu ◽  
Minming Zheng ◽  
Hua Li ◽  
Yunjia Liu ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Han Chinese ◽  
Behcet's Disease

scholarly journals Analysis of the association between Fc receptor family gene polymorphisms and ocular Behçet’s disease in Han Chinese

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Donglei Zhang ◽  
Jieying Qin ◽  
Lin Li ◽  
Guannan Su ◽  
Guo Huang ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Gene Polymorphisms ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Fc Receptor ◽  
Han Chinese ◽  
Behcet's Disease ◽  
Family Gene ◽  
Receptor Family

scholarly journals Association of a TNIP1 Polymorphism with Vogt-Koyanagi-Harada Syndrome but Not with Ocular Behcet’s Disease in Han Chinese

PLoS ONE ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. e95573 ◽  
Author(s):  
Yanyun Shi ◽  
Yading Jia ◽  
Shengping Hou ◽  
Jing Fang ◽  
Yan Zhou ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Han Chinese ◽  
Behcet's Disease

scholarly journals Associations between TNFSF4, TNFSF8 and TNFSF15 and Behçet's disease but not VKH syndrome in Han Chinese

Oncotarget ◽  
2017 ◽  
Vol 8 (62) ◽  
pp. 105037-105046 ◽  
Author(s):  
Yan Jiang ◽  
Ling Cheng ◽  
Xin Li ◽  
Wenke Zhou ◽  
Li Zhang
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Han Chinese ◽  
Behcet's Disease ◽  
Vkh Syndrome

scholarly journals Identification of susceptibility SNPs in IL10 and IL23R-IL12RB2 for Behçet's disease in Han Chinese

2017 ◽  
Vol 139 (2) ◽  
pp. 621-627 ◽  
Author(s):  
Hongsong Yu ◽  
Minming Zheng ◽  
Lijun Zhang ◽  
Hua Li ◽  
Yunyun Zhu ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Han Chinese ◽  
Behcet's Disease

scholarly journals Association of genetic variations in PTPN2 and CD122 with ocular Behcet’s disease

2018 ◽  
Vol 102 (7) ◽  
pp. 996-1002 ◽  
Author(s):  
Qi Zhang ◽  
Hua Li ◽  
Shengping Hou ◽  
Hongsong Yu ◽  
Guannan Su ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Mononuclear Cells ◽  
Behçet's Disease ◽  
Genetic Variations ◽  
Janus Kinase ◽  
Behcet's Disease ◽  
Pathergy Test ◽  
Significant Difference

BackgroundProtein tyrosine phosphatases (PTPs) play critical roles in human autoimmunity. Previous studies found that PTPN2 may be the key regulatory factor in the T-cell-mediated immune response. PTPN2 regulates the Janus kinase/signal transducers and activators of transcription pathway by inhibiting signalling via the interleukin (IL)-2 receptor (CD122). An association between genetic variations in PTPN2 and CD122 with ocular Behcet’s disease (BD) has not yet been addressed and was therefore the purpose of this study.MethodsA two-stage case–control study was performed in 906 patients with ocular BD and 2178 healthy controls. Genotyping analysis of 11 single nucleotide polymorphisms was carried out. The expression of PTPN2 in peripheral blood mononuclear cells (PBMCs) was quantified by real-time PCR and cytokine production was measured by ELISA.ResultsThe frequency of the GG genotype of PTPN2-rs7234029 was significantly lower in patients with ocular BD (p=1.94×10−5, pc=8.34×10−4, OR=0.466). Stratification according to gender showed that rs7234029 was significantly associated with BD in men. A stratified analysis according to the main clinical features showed that rs7234029 was significantly associated with genital ulcers, skin lesions and a positive pathergy test. No association could be detected between BD and CD122 gene polymorphisms. Functional studies showed that rs7234029 GG genotype carriers had a higher PNPT2 mRNA expression level than those which carrying the AA or AG genotype, and a decreased secretion of IL-17 and tumour necrosis factor-alpha was seen by PBMCs from GG carriers. No significant difference could be detected concerning IL-1β or IL-6 production by stimulated PBMCs between the different genotype groups.ConclusionsThis study shows that a PTPN2-rs7234029 polymorphism is associated with ocular BD and is strongly influenced by gender. In addition, our results suggest that the genetic association with PTPN2 may involve the regulation of PTPN2 mRNA expression and cytokine secretion.

scholarly journals Association of TNFSF4 Polymorphisms with Vogt-Koyanagi-Harada and Behcet’s Disease in Han Chinese

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Sha Lu ◽  
Shengfang Song ◽  
Shengping Hou ◽  
Hua Li ◽  
Peizeng Yang
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Han Chinese ◽  
Behcet's Disease

Genetic variants in the JAK1 gene confer higher risk of Behcet’s disease with ocular involvement in Han Chinese

2013 ◽  
Vol 132 (9) ◽  
pp. 1049-1058 ◽  
Author(s):  
Shengping Hou ◽  
Jian Qi ◽  
Qi Zhang ◽  
Dan Liao ◽  
Qi Li ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Genetic Variants ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Han Chinese ◽  
Ocular Involvement ◽  
Behcet's Disease

Genetic Variations of IL17F and IL23A Show Associations with Behçet’s Disease and Vogt-Koyanagi-Harada Syndrome

Ophthalmology ◽  
2015 ◽  
Vol 122 (3) ◽  
pp. 518-523 ◽  
Author(s):  
Shengping Hou ◽  
Dan Liao ◽  
Jun Zhang ◽  
Jing Fang ◽  
Lu Chen ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Genetic Variations ◽  
Behcet's Disease
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