scholarly journals Reconstruction of diaminopimelic acid biosynthesis allows characterisation of Mycobacterium tuberculosis N-succinyl-L,L-diaminopimelic acid desuccinylase

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Veeraraghavan Usha ◽  
Adrian J. Lloyd ◽  
David I. Roper ◽  
Christopher G. Dowson ◽  
Guennadi Kozlov ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Diaminopimelic Acid ◽  
Acid Biosynthesis

Inhibition of the Synthesis of Wax D Peptidoglycolipid of Mycobacterium tuberculosis by d -Cycloserine

1970 ◽  
Vol 1 (1) ◽  
pp. 74-77 ◽  
Author(s):  
Hugo L. David ◽  
Dexter S. Goldman ◽  
Kuni Takayama
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Functional Group ◽  
Diaminopimelic Acid ◽  
Inhibition Of Growth ◽  
In Cells

The antibiotic d -cycloserine inhibits the synthesis of the wax D peptidoglycolipid in cells of the H37Ra strain of Mycobacterium tuberculosis . This inhibition occurs at a lower concentration of the drug than that required for the inhibition of growth. The inhibition is completely reversed by d -alanine. An arabino-galactan-galactosamine-(diaminopimelic acid)-mycolate accumulates in H37Ra cells exposed to the antibiotic. The chemical and functional group analyses of this lipid suggests it to be a possible precursor to the synthesis of wax D.

Peptides of 2-aminopimelic acid: antibacterial agents that inhibit diaminopimelic acid biosynthesis

1986 ◽  
Vol 29 (1) ◽  
pp. 89-95 ◽  
Author(s):  
David A. Berges ◽  
Walter E. DeWolf ◽  
George L. Dunn ◽  
Sarah F. Grappel ◽  
David J. Newman ◽  
...  
Keyword(s):  
Antibacterial Agents ◽  
Diaminopimelic Acid ◽  
Acid Biosynthesis
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