scholarly journals Erratum: Corrigendum: Integrated analysis of the involvement of nitric oxide synthesis in mitochondrial proliferation, mitochondrial deficiency and apoptosis in skeletal muscle fibres

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Gabriela Silva Rodrigues ◽  
Rosely Oliveira Godinho ◽  
Beatriz Hitomi Kiyomoto ◽  
Juliana Gamba ◽  
Acary Souza Bulle Oliveira ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Skeletal Muscle ◽  
Integrated Analysis ◽  
Muscle Fibres ◽  
Nitric Oxide Synthesis ◽  
Skeletal Muscle Fibres

scholarly journals Nitric oxide synthase in skeletal muscle fibres of patients with type 2 diabetes

2012 ◽  
Author(s):  
Karla Punkt ◽  
Katharina Kandt ◽  
Andreas Oberbach ◽  
Volker Adams ◽  
Igor Buchwalow ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Type 2 Diabetes ◽  
Skeletal Muscle ◽  
Nitric Oxide Synthase ◽  
Muscle Fibres ◽  
Oxide Synthase ◽  
Skeletal Muscle Fibres

scholarly journals Integrated analysis of the involvement of nitric oxide synthesis in mitochondrial proliferation, mitochondrial deficiency and apoptosis in skeletal muscle fibres

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Gabriela Silva Rodrigues ◽  
Rosely Oliveira Godinho ◽  
Beatriz Hitomi Kiyomoto ◽  
Juliana Gamba ◽  
Acary Souza Bulle Oliveira ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Mitochondrial Function ◽  
Mitochondrial Diseases ◽  
Integrated Analysis ◽  
Muscle Fibres ◽  
Mitochondrial Content ◽  
Mitochondrial Dna Mutation ◽  
Dna Mutation ◽  
Mitochondrial Abnormalities ◽  
Skeletal Muscle Fibres

Abstract Nitric oxide (NO) is an important signaling messenger involved in different mitochondrial processes but only few studies explored the participation of NO in mitochondrial abnormalities found in patients with genetic mitochondrial deficiencies. In this study we verified whether NO synthase (NOS) activity was altered in different types of mitochondrial abnormalities and whether changes in mitochondrial function and NOS activity could be associated with the induction of apoptosis. We performed a quantitative and integrated analysis of NOS activity in individual muscle fibres of patients with mitochondrial diseases, considering mitochondrial function (cytochrome-c-oxidase activity), mitochondrial content, mitochondrial DNA mutation and presence of apoptotic nuclei. Our results indicated that sarcolemmal NOS activity was increased in muscle fibres with mitochondrial proliferation, supporting the relevance of neuronal NOS in the mitochondrial biogenesis process. Sarcoplasmic NOS activity was reduced in cytochrome-c-oxidase deficient fibres, probably as a consequence of the involvement of NO in the regulation of the respiratory chain. Alterations in NOS activity or mitochondrial abnormalities were not predisposing factors to apoptotic nuclei. Taken together, our results show that NO can be considered a potential molecular target for strategies to increase mitochondrial content and indicate that this approach may not be associated with increased apoptotic events.

scholarly journals Increased Generation of Intracellular Nitric Oxide During Contraction of Isolated Skeletal Muscle Fibres

2006 ◽  
Vol 20 (5) ◽  
Author(s):  
Deborah Pye ◽  
Jesus Palomero ◽  
Tabitha Kabayo ◽  
Malcolm J Jackson
Keyword(s):  
Nitric Oxide ◽  
Skeletal Muscle ◽  
Muscle Fibres ◽  
Skeletal Muscle Fibres

Effect of passive stretch on intracellular nitric oxide and superoxide activities in single skeletal muscle fibres: Influence of ageing

2011 ◽  
Vol 46 (1) ◽  
pp. 30-40 ◽  
Author(s):  
Jesus Palomero ◽  
Deborah Pye ◽  
Tabitha Kabayo ◽  
Malcolm J. Jackson
Keyword(s):  
Nitric Oxide ◽  
Skeletal Muscle ◽  
Muscle Fibres ◽  
Skeletal Muscle Fibres ◽  
Passive Stretch

scholarly journals Effect of nitric oxide on single skeletal muscle fibres from the mouse

1998 ◽  
Vol 509 (2) ◽  
pp. 577-586 ◽  
Author(s):  
Francisco H. Andrade ◽  
Michael B. Reid ◽  
David G. Allen ◽  
Håkan Westerblad
Keyword(s):  
Nitric Oxide ◽  
Skeletal Muscle ◽  
Muscle Fibres ◽  
Skeletal Muscle Fibres

scholarly journals Real-time measurement of nitric oxide in single mature mouse skeletal muscle fibres during contractions

2007 ◽  
Vol 581 (1) ◽  
pp. 309-318 ◽  
Author(s):  
Deborah Pye ◽  
Jesus Palomero ◽  
Tabitha Kabayo ◽  
Malcolm J. Jackson
Keyword(s):  
Nitric Oxide ◽  
Skeletal Muscle ◽  
Real Time ◽  
Time Measurement ◽  
Muscle Fibres ◽  
Mouse Skeletal Muscle ◽  
Real Time Measurement ◽  
Mature Mouse ◽  
Skeletal Muscle Fibres
Sign in / Sign up

Export Citation Format

Share Document