scholarly journals RNA-binding protein RBM3 prevents NO-induced apoptosis in human neuroblastoma cells by modulating p38 signaling and miR-143

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Hai-Jie Yang ◽  
Fei Ju ◽  
Xin-Xin Guo ◽  
Shuang-Ping Ma ◽  
Lei Wang ◽  
...  
Keyword(s):  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Neuroblastoma Cells ◽  
Human Neuroblastoma Cells ◽  
Human Neuroblastoma ◽  
Induced Apoptosis

scholarly journals HuB and HuD repress telomerase activity by dissociating HuR from TERC

2021 ◽  
Author(s):  
Xiaolei Cheng ◽  
Xiaoping Gu ◽  
Tianjiao Xia ◽  
Zhengliang Ma ◽  
Zhongzhou Yang ◽  
...  
Keyword(s):  
Noncoding Rna ◽  
Rna Binding ◽  
Rna Binding Protein ◽  
Neuroblastoma Cells ◽  
Telomerase Activity ◽  
Core Complex ◽  
Human Neuroblastoma Cells ◽  
Human Neuroblastoma ◽  
Specific Proteins

Abstract The ubiquitous RNA-binding protein HuR (ELAVL1) promotes telomerase activity by associating with the telomerase noncoding RNA TERC. However, the role of the neural-specific members HuB, HuC, and HuD (ELAVL2–4) in telomerase activity is unknown. Here, we report that HuB and HuD, but not HuC, repress telomerase activity in human neuroblastoma cells. By associating with AU-rich sequences in TERC, HuB and HuD repressed the assembly of the TERT–TERC core complex. Furthermore, HuB and HuD competed with HuR for binding to TERC and antagonized the function of HuR that was previously shown to enhance telomerase activity to promote cell growth. Our findings reveal a novel mechanism controlling telomerase activity in human neuroblastoma cells that involves a competition between HuR and the related, neural-specific proteins HuB and HuD.

Bax-activation during lidocaine-induced apoptosis in human neuroblastoma cells

2007 ◽  
Vol 32 (Suppl. 1) ◽  
pp. 186
Author(s):  
M. F. Stevens ◽  
S. Braun ◽  
H. Hermanns ◽  
P. Lipfert ◽  
F. Essmann ◽  
...  
Keyword(s):  
Neuroblastoma Cells ◽  
Human Neuroblastoma Cells ◽  
Human Neuroblastoma ◽  
Induced Apoptosis

Morroniside Prevents Peroxide-induced Apoptosis by Induction of Endogenous Glutathione in Human Neuroblastoma Cells

2007 ◽  
Vol 28 (2) ◽  
pp. 293-305 ◽  
Author(s):  
Wen Wang ◽  
Wenting Huang ◽  
Lin Li ◽  
Houxi Ai ◽  
Fangling Sun ◽  
...  
Keyword(s):  
Neuroblastoma Cells ◽  
Human Neuroblastoma Cells ◽  
Human Neuroblastoma ◽  
Induced Apoptosis

Fraxetin prevents rotenone-induced apoptosis by induction of endogenous glutathione in human neuroblastoma cells

2005 ◽  
Vol 53 (1) ◽  
pp. 48-56 ◽  
Author(s):  
María Isabel Sánchez-Reus ◽  
Irene Iglesias Peinado ◽  
María Francisca Molina-Jiménez ◽  
Juana Benedí
Keyword(s):  
Neuroblastoma Cells ◽  
Human Neuroblastoma Cells ◽  
Human Neuroblastoma ◽  
Induced Apoptosis

Expression and Down-Regulation by Retinoic Acid of IGF Binding Protein-2 and -4 in Medium from Human Neuroblastoma Cells

1994 ◽  
Vol 6 (4) ◽  
pp. 409-413 ◽  
Author(s):  
Sergio Bernardini ◽  
Stefano Cianfarani ◽  
Anna Spagnoli ◽  
Margherita Annicchiarico-Petruzzelli ◽  
Gerry Melino ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Binding Protein ◽  
Neuroblastoma Cells ◽  
Human Neuroblastoma Cells ◽  
Down Regulation ◽  
Human Neuroblastoma ◽  
Igf Binding ◽  
Igf Binding Protein
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