scholarly journals MicroRNA exocytosis by large dense-core vesicle fusion

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Alican Gümürdü ◽  
Ramazan Yildiz ◽  
Erden Eren ◽  
Gökhan Karakülah ◽  
Turgay Ünver ◽  
...  
Keyword(s):  
Vesicle Fusion ◽  
Dense Core ◽  
Dense Core Vesicle ◽  
Large Dense Core Vesicle

scholarly journals Phosphatidylinositol phosphate kinase type I  regulates dynamics of large dense-core vesicle fusion

2005 ◽  
Vol 102 (14) ◽  
pp. 5204-5209 ◽  
Author(s):  
L.-W. Gong ◽  
G. Di Paolo ◽  
E. Diaz ◽  
G. Cestra ◽  
M.-E. Diaz ◽  
...  
Keyword(s):  
Vesicle Fusion ◽  
Dense Core ◽  
Dense Core Vesicle ◽  
Type I ◽  
Large Dense Core Vesicle ◽  
Phosphatidylinositol Phosphate ◽  
Phosphatidylinositol Phosphate Kinase

scholarly journals Quantitative analysis of dense-core vesicle fusion in rodent CNS neurons

2021 ◽  
Vol 2 (1) ◽  
pp. 100325
Author(s):  
Alessandro Moro ◽  
Rein I. Hoogstraaten ◽  
Claudia M. Persoon ◽  
Matthijs Verhage ◽  
Ruud F. Toonen
Keyword(s):  
Quantitative Analysis ◽  
Vesicle Fusion ◽  
Dense Core ◽  
Dense Core Vesicle ◽  
Cns Neurons

scholarly journals Intracellular calcium dependence of large dense-core vesicle exocytosis in the absence of synaptotagmin I

2001 ◽  
Vol 98 (20) ◽  
pp. 11680-11685 ◽  
Author(s):  
T. Voets ◽  
T. Moser ◽  
P.-E. Lund ◽  
R. H. Chow ◽  
M. Geppert ◽  
...  
Keyword(s):  
Intracellular Calcium ◽  
Dense Core ◽  
Dense Core Vesicle ◽  
Calcium Dependence ◽  
Large Dense Core Vesicle ◽  
Synaptotagmin I ◽  
Vesicle Exocytosis

scholarly journals MicroRNA exocytosis by large dense-core vesicle fusion

2016 ◽  
Author(s):  
Alican Gümürdü ◽  
Ramazan Yildiz ◽  
Erden Eren ◽  
Gökhan Karakülah ◽  
Turgay Ünver ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Vesicle Fusion ◽  
Dense Core ◽  
Snare Complex ◽  
Dense Core Vesicle ◽  
Next Generation ◽  
Dense Core Vesicles ◽  
Large Dense Core Vesicles ◽  
Extracellular Mirna ◽  
Generation Sequencing

AbstractNeurotransmitters and peptide hormones are secreted into outside the cell by a vesicle fusion process. Although non-coding RNA (ncRNA) that include microRNA (miRNA) regulates gene expression inside the cell where they are transcribed, extracellular miRNA has been recently discovered outside the cells, proposing that miRNA might be released to participate in cell-to-cell communication. Despite its importance of extracellular miRNA, the molecular mechanisms by which miRNA can be stored in vesicles and released by vesicle fusion remain enigmatic. Using next-generation sequencing, vesicle purification techniques, and synthetic neurotransmission, we observe that large dense-core vesicles (LDCVs) contain a variety of miRNAs including miR-375. Furthermore, miRNA exocytosis is mediated by the SNARE complex and accelerated by Ca2+. Our results suggest that miRNA can be a novel neuromodulator that can be stored in vesicles and released by vesicle fusion together with classical neurotransmitters.One Sentence SummaryUsing next-generation sequencing (NGS) for microRNA (miRNA) and synthetic neurotransmission, we observed that large dense-core vesicles (LDCVs) contain a variety of miRNA together with classical neurotransmitters, and that miRNA can be released by vesicle fusion mediated by SNARE.

scholarly journals Tetanus insensitive VAMP2 differentially restores synaptic and dense core vesicle fusion in tetanus neurotoxin treated neurons

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Rein I. Hoogstraaten ◽  
Linda van Keimpema ◽  
Ruud F. Toonen ◽  
Matthijs Verhage
Keyword(s):  
Vesicle Fusion ◽  
Dense Core ◽  
Dense Core Vesicle ◽  
Tetanus Neurotoxin

Large dense-core vesicle exocytosis from mouse dorsal root ganglion neurons is regulated by neuropeptide Y

Neuroscience ◽  
2017 ◽  
Vol 346 ◽  
pp. 1-13 ◽  
Author(s):  
Anneka Bost ◽  
Ali H. Shaib ◽  
Yvonne Schwarz ◽  
Barbara A. Niemeyer ◽  
Ute Becherer
Keyword(s):  
Dorsal Root Ganglion ◽  
Neuropeptide Y ◽  
Dorsal Root ◽  
Dense Core ◽  
Dorsal Root Ganglion Neurons ◽  
Dense Core Vesicle ◽  
Large Dense Core Vesicle ◽  
Vesicle Exocytosis ◽  
Mouse Dorsal Root Ganglion ◽  
Ganglion Neurons
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