CHAPTER 6. Discovery and Use of Natural Products and Derivatives as Chemical Probes

2020 ◽  
pp. 124-149
Author(s):  
Masaki Kita ◽  
Hideo Kigoshi
Keyword(s):  
Natural Products ◽  
Chemical Probes

scholarly journals Natural Products as Chemical Probes

2010 ◽  
Vol 5 (7) ◽  
pp. 639-653 ◽  
Author(s):  
Erin E. Carlson
Keyword(s):  
Natural Products ◽  
Chemical Probes

scholarly journals Natural products triptolide, celastrol, and withaferin A inhibit the chaperone activity of peroxiredoxin I

2015 ◽  
Vol 6 (7) ◽  
pp. 4124-4130 ◽  
Author(s):  
Qian Zhao ◽  
Yu Ding ◽  
Zhangshuang Deng ◽  
On-Yi Lee ◽  
Peng Gao ◽  
...  
Keyword(s):  
Natural Products ◽  
Chaperone Activity ◽  
Withaferin A ◽  
Chemical Probes ◽  
Peroxiredoxin I

The natural products triptolide, withaferin A and celastrol have been discovered to be novel Prx I chaperone inhibitors using synthetic chemical probes.

scholarly journals Chemical proteomics approaches for identifying the cellular targets of natural products

2016 ◽  
Vol 33 (5) ◽  
pp. 681-708 ◽  
Author(s):  
M. H. Wright ◽  
S. A. Sieber
Keyword(s):  
Natural Products ◽  
Protein Binding ◽  
Living Systems ◽  
Chemical Probes ◽  
Chemical Proteomics ◽  
Cellular Targets ◽  
Binding Partners

This review focuses on chemical probes to identify the protein binding partners of natural products in living systems.

Detectives and helpers: Natural products as resources for chemical probes and compound libraries

2020 ◽  
Vol 216 ◽  
pp. 107688
Author(s):  
Anutthaman Parthasarathy ◽  
Pavan K. Mantravadi ◽  
Karunakaran Kalesh
Keyword(s):  
Natural Products ◽  
Chemical Probes ◽  
Compound Libraries

scholarly journals Bicyclic enol cyclocarbamates inhibit penicillin-binding proteins

2017 ◽  
Vol 15 (4) ◽  
pp. 894-910 ◽  
Author(s):  
Paul Dockerty ◽  
Jerre G. Edens ◽  
Menno B. Tol ◽  
Danae Morales Angeles ◽  
Arnau Domenech ◽  
...  
Keyword(s):  
Natural Products ◽  
Binding Proteins ◽  
Chemical Probes ◽  
Penicillin Binding Proteins

Natural products form attractive leads for the development of chemical probes and drugs.

scholarly journals Diastereoselective synthesis and biological evaluation of enantiomerically pure tricyclic indolines

2017 ◽  
Vol 15 (19) ◽  
pp. 4241-4245 ◽  
Author(s):  
W. He ◽  
B. M. Griffiths ◽  
W. Wang ◽  
X. Wang
Keyword(s):  
Natural Products ◽  
Biological Evaluation ◽  
Diastereoselective Synthesis ◽  
Chemical Probes ◽  
Enantiomerically Pure ◽  
Synthesis And Biological Evaluation

Tricyclic indolines are common in both natural products and synthetic chemical probes.

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