Chapter 3. Targeted Intracellular Protein Degradation as a Potential Therapeutic Strategy

New Frontiers in Chemical Biology - Drug Discovery ◽

10.1039/9781849732178-00064 ◽

2010 ◽

pp. 64-96

Author(s):

A.R. Schneekloth ◽

C.M. Crews

Keyword(s):

Protein Degradation ◽

Therapeutic Strategy ◽

Intracellular Protein ◽

Intracellular Protein Degradation

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Faculty Opinions recommendation of Structural disorder serves as a weak signal for intracellular protein degradation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717968046.793467711 ◽

2012 ◽

Author(s):

Vladimir Uversky

Keyword(s):

Protein Degradation ◽

Structural Disorder ◽

Weak Signal ◽

Intracellular Protein ◽

Intracellular Protein Degradation

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Intracellular protein degradation in Neurospora crassa.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)50282-9 ◽

1979 ◽

Vol 254 (15) ◽

pp. 7047-7054

Author(s):

E Martegani ◽

L Alberghina

Keyword(s):

Neurospora Crassa ◽

Protein Degradation ◽

Intracellular Protein ◽

Intracellular Protein Degradation

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Intracellular protein degradation in Leishmania tropica promastigotes

Molecular and Biochemical Parasitology ◽

10.1016/0166-6851(83)90113-5 ◽

1983 ◽

Vol 7 (1) ◽

pp. 19-26 ◽

Author(s):

Michael W. Simon ◽

Antony J. Mukkada

Keyword(s):

Protein Degradation ◽

Leishmania Tropica ◽

Intracellular Protein ◽

Intracellular Protein Degradation

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Altered intracellular protein degradation in aging: A possible cause of proliferative arrest

Experimental Gerontology ◽

10.1016/0531-5565(89)90051-x ◽

1989 ◽

Vol 24 (5-6) ◽

pp. 451-459 ◽

Author(s):

J. Fred Dice

Keyword(s):

Protein Degradation ◽

Intracellular Protein ◽

Intracellular Protein Degradation ◽

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Ubiquitin and the enigma of intracellular protein degradation

EJB Reviews ◽

10.1007/978-3-642-85252-7_14 ◽

1995 ◽

pp. 191-220

Author(s):

Herbert P. Jennissen

Keyword(s):

Protein Degradation ◽

Intracellular Protein ◽

Intracellular Protein Degradation

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Intracellular Protein Degradation: From a Vague Idea, Through the Lysosome and the Ubiquitin—Proteasome System, and onto Human Diseases and Drug Targeting (Nobel Lecture)

10.1002/chin.200549272 ◽

2005 ◽

Vol 36 (49) ◽

Author(s):

Aaron Ciechanover

Keyword(s):

Protein Degradation ◽

Drug Targeting ◽

Ubiquitin Proteasome System ◽

Human Diseases ◽

Intracellular Protein ◽

Nobel Lecture ◽

Intracellular Protein Degradation ◽

Ubiquitin Proteasome

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An abnormality in intracellular protein degradation in fibroblasts from patients with I-cell disease

Clinica Chimica Acta ◽

10.1016/0009-8981(84)90207-9 ◽

1984 ◽

Vol 140 (3) ◽

pp. 257-265

Author(s):

Sheena M. Cockle ◽

Roger T. Dean

Keyword(s):

Protein Degradation ◽

Cell Disease ◽

Intracellular Protein ◽

Intracellular Protein Degradation

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Intracellular Protein Degradation: From a Vague Idea, through the Lysosome and the Ubiquitin-Proteasome System, and onto Human Diseases and Drug Targeting (Nobel Lecture)

Angewandte Chemie International Edition ◽

10.1002/anie.200501428 ◽

2005 ◽

Vol 44 (37) ◽

pp. 5944-5967 ◽

Author(s):

Aaron Ciechanover

Keyword(s):

Protein Degradation ◽

Drug Targeting ◽

Ubiquitin Proteasome System ◽

Human Diseases ◽

Intracellular Protein ◽

Nobel Lecture ◽

Intracellular Protein Degradation ◽

Ubiquitin Proteasome

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Measuring in vivo intracellular protein degradation rates in animal systems1

Journal of Animal Science ◽

10.2527/jas.2007-0430 ◽

2008 ◽

Vol 86 (suppl_14) ◽

pp. E3-E12 ◽

Author(s):

W. G. Bergen

Keyword(s):

Protein Degradation ◽

Intracellular Protein ◽

Degradation Rates ◽

Intracellular Protein Degradation

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Modulation of intracellular protein degradation by SSB1-SIS1 chaperon system in yeastS. cerevisiae

FEBS Letters ◽

10.1016/s0014-5793(97)00535-8 ◽

1997 ◽

Vol 409 (2) ◽

pp. 307-311 ◽

Author(s):

Masayuki Ohba

Keyword(s):

Protein Degradation ◽

Intracellular Protein ◽

Intracellular Protein Degradation

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