Oligonucleotide analogues containing (2″S )- and (2″R)-2′-O,3′-C-((2″-C-hydroxymethyl)ethylene)-linked bicyclic nucleoside monomers: † Synthesis, RNA-selective binding, and diastereoselective formation of a very stable homocomplex based on T∶T base pairing

1999 ◽  
pp. 2543-2551 ◽  
Author(s):  
Michael Raunkjr ◽  
Carl E. Olsen ◽  
Jesper Wengel
Keyword(s):  
Base Pairing ◽  
Selective Binding ◽  
Oligonucleotide Analogues

Cambiarenes: Single-Step Synthesis and Anion Binding of a Clip- Shaped Macrocycle with a Redox-Active Core

2019 ◽  
Author(s):  
Riley J. Petersen ◽  
Brett J. Rozeboom ◽  
Shalisa Oburn ◽  
Nolan Blythe ◽  
Tanner Rathje ◽  
...  
Keyword(s):  
Electron Density ◽  
Single Step ◽  
Anion Binding ◽  
Host Molecule ◽  
Selective Binding ◽  
The Core ◽  
Redox Active ◽  
Active Core ◽  
Guest Binding

<div>We report the synthesis of a novel macrocyclic host molecule that forms in a single step from commercially available starting materials. The core of the macrocycle backbone possesses two quinone rings and, thus, is redox-active. Host-guest binding involving the clip-shaped cavity indicates selective binding of pyridine <i>N</i>-oxides based of the electron density of and steric bulk of the anionic oxygen.</div>

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