Relative acidity scale of bile acids through ESI-MS measurements

The relative acidity of substituted picric acids has been determined using special non-aqueous titration techniques. Other organic and inorganic acids, whose acidities in water are well known, were also determined using this non-aqueous method. A correlation of the relative acidities of known acids in water with the relative acidities of these same acids, as measured under the non-aqueous conditions used, was excellent. Using this technique a single relative acidity scale was determined ranging from acids as strong as perchloric to acids as weak as acetic acid.

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Semi-empirical calculations on the structure of the oxonium ion in various crystal sites and relative acidity scale

Theoretica Chimica Acta ◽

10.1007/bf00547068 ◽

1976 ◽

Vol 42 (2) ◽

pp. 145-154 ◽

Cited By ~ 5

Author(s):

Michel Fournier ◽

Marcel Allavena ◽

Antoine Potier

Keyword(s):

Semi Empirical ◽

Acidity Scale ◽

Relative Acidity

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Improved analysis of bile acids in tissues and intestinal contents of rats using LC/ESI-MS

The Journal of Lipid Research ◽

10.1194/jlr.d800041-jlr200 ◽

2008 ◽

Vol 50 (1) ◽

pp. 173-180 ◽

Cited By ~ 91

Author(s):

Masahito Hagio ◽

Megumi Matsumoto ◽

Michihiro Fukushima ◽

Hiroshi Hara ◽

Satoshi Ishizuka

Keyword(s):

Bile Acids ◽

Esi Ms ◽

Intestinal Contents

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Detection of Δ4-3-oxo-steroid 5β-reductase deficiency by LC–ESI-MS/MS measurement of urinary bile acids

Journal of Chromatography B ◽

10.1016/j.jchromb.2012.05.023 ◽

2012 ◽

Vol 900 ◽

pp. 24-31 ◽

Cited By ~ 28

Author(s):

Akina Muto ◽

Hajime Takei ◽

Atsushi Unno ◽

Tsuyoshi Murai ◽

Takao Kurosawa ◽

...

Keyword(s):

Bile Acids ◽

Reductase Deficiency ◽

Esi Ms

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Improved synthesis of glycine, taurine and sulfate conjugated bile acids as reference compounds and internal standards for ESI–MS/MS urinary profiling of inborn errors of bile acid synthesis

Chemistry and Physics of Lipids ◽

10.1016/j.chemphyslip.2017.03.004 ◽

2017 ◽

Vol 204 ◽

pp. 43-56 ◽

Cited By ~ 9

Author(s):

Elena Donazzolo ◽

Antonina Gucciardi ◽

Daniela Mazzier ◽

Cristina Peggion ◽

Paola Pirillo ◽

...

Keyword(s):

Bile Acid ◽

Bile Acids ◽

Acid Synthesis ◽

Bile Acid Synthesis ◽

Inborn Errors ◽

Internal Standards ◽

Esi Ms ◽

Conjugated Bile Acids

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Identification of S-acyl glutathione conjugates of bile acids in human bile by means of LC/ESI-MS

Steroids ◽

10.1016/j.steroids.2011.10.001 ◽

2011 ◽

Vol 76 (14) ◽

pp. 1609-1614 ◽

Cited By ~ 9

Author(s):

Kuniko Mitamura ◽

Naohiro Hori ◽

Takashi Iida ◽

Mitsuyoshi Suzuki ◽

Toshiaki Shimizu ◽

...

Keyword(s):

Bile Acids ◽

Human Bile ◽

Glutathione Conjugates ◽

Esi Ms

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Coulometric-potentiometric determination of autoprotolysis constant and relative acidity scale of water

Journal of the Serbian Chemical Society ◽

10.2298/jsc100316094d ◽

2010 ◽

Vol 75 (11) ◽

pp. 1575-1582 ◽

Cited By ~ 1

Author(s):

Radmila Dzudovic ◽

Ljiljana Jaksic

Keyword(s):

Supporting Electrolyte ◽

Sodium Perchlorate ◽

Electrolytic Cell ◽

Electrode Pair ◽

Strong Base ◽

Palladium Electrode ◽

Oxidation Of Hydrogen ◽

The Difference ◽

Acidity Scale ◽

Relative Acidity

The autoprotolysis constant and relative acidity scale of water were determined by applying the coulometric-potentiometric method and a hydrogen/palladium (H2/Pd) generator anode. In the described procedure for the evaluation of autoprotolysis constant, a strong base generated coulometrically at the platinum cathode in situ in the electrolytic cell, in presence of sodium perchlorate as the supporting electrolyte, is titrated with hydrogen ions obtained by the anodic oxidation of hydrogen dissolved in palladium electrode. The titration was carried out with a glass-SCE electrode pair at 25.0?0.1?C. The value obtained pKw = 13.91 ? 0.06 is in agreement with literature data. The range of acidity scale of water is determined from the difference between the halfneutralization potentials of electrogenerated perchloric acid and that of sodium hydroxide in a sodium perchlorate medium. The halfneutralization potentials were measured using both a glass-SCE and a (H2/Pd)ind-SCE electrode pairs. A wider range of relative acidity scale of water was obtained with the glass-SCE electrode pair.

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