Computational study of the mechanism of half-reactions in class 1A dihydroorotate dehydrogenase from Trypanosoma cruzi

2013 ◽  
Vol 15 (43) ◽  
pp. 18863 ◽  
Author(s):  
Natália de Farias Silva ◽  
Jerônimo Lameira ◽  
Cláudio Nahum Alves ◽  
Sergio Martí
Keyword(s):  
Trypanosoma Cruzi ◽  
Computational Study ◽  
Dihydroorotate Dehydrogenase

Genetic diversity and kinetic properties of Trypanosoma cruzi dihydroorotate dehydrogenase isoforms

2006 ◽  
Vol 55 (1) ◽  
pp. 11-16 ◽  
Author(s):  
Idalia Sariego ◽  
Takeshi Annoura ◽  
Takeshi Nara ◽  
Muneaki Hashimoto ◽  
Akiko Tsubouchi ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Trypanosoma Cruzi ◽  
Kinetic Properties ◽  
Dihydroorotate Dehydrogenase

Characterization of the dihydroorotate dehydrogenase as a soluble fumarate reductase in Trypanosoma cruzi

2002 ◽  
Vol 122 (2) ◽  
pp. 189-200 ◽  
Author(s):  
Eizo Takashima ◽  
Daniel Ken Inaoka ◽  
Arihiro Osanai ◽  
Takeshi Nara ◽  
Masao Odaka ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Fumarate Reductase ◽  
Dihydroorotate Dehydrogenase

scholarly journals Computational and Investigative Study of Flavonoids Active against Trypanosoma cruzi and Leishmania spp

2015 ◽  
Vol 10 (6) ◽  
pp. 1934578X1501000 ◽  
Author(s):  
Frederico F. Ribeiro ◽  
Francisco J.B.M. Junior ◽  
Marcelo S. da Silva ◽  
Marcus Tullius Scotti ◽  
Luciana Scotti
Keyword(s):  
Antioxidant Activity ◽  
Trypanosoma Cruzi ◽  
Dimethyl Ether ◽  
Leishmania Species ◽  
Dihydroorotate Dehydrogenase ◽  
In Silico Docking ◽  
Leishmania Spp ◽  
Parasitic Activity ◽  
Molecular Maps ◽  
Quantum Parameters

Flavonoid compounds active against Trypanosoma cruzi and Leishmania species were submitted to several methodologies in silico: docking with the enzymes cruzain and trypanothione reductase (from T. cruzi), and N-myristoyltransferase, dihydroorotate dehydrogenase, and trypanothiona reductase (from Leishmania spp). Molecular maps of the complexes and the ligands were calculated. In order to compare and evaluate the antioxidant activity of the flavonoids with their antiprotozoal activity, quantum parameters were calculated. Considering the energies, interactions, and hydrophobic surfaces calculated, the flavonoids chrysin dimethyl ether against T. cruzi, and ladanein against Leishmania sp. presented the best results. The antioxidant activity did not show any correlation with anti-parasitic activity; only chrysin and its dimethyl ether showed favorable anti-parasitic results. This study hopes to contribute to existing research on these natural products against these tropical parasites.

Kinetic mechanism and catalysis of Trypanosoma cruzi dihydroorotate dehydrogenase enzyme evaluated by isothermal titration calorimetry

2010 ◽  
Vol 399 (1) ◽  
pp. 13-22 ◽  
Author(s):  
Juliana Cheleski ◽  
Helton José Wiggers ◽  
Ana Paula Citadini ◽  
Antônio José da Costa Filho ◽  
Maria Cristina Nonato ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Isothermal Titration Calorimetry ◽  
Kinetic Mechanism ◽  
Titration Calorimetry ◽  
Dihydroorotate Dehydrogenase ◽  
Dehydrogenase Enzyme

Design and synthesis of potent substrate-based inhibitors of the Trypanosoma cruzi dihydroorotate dehydrogenase

2017 ◽  
Vol 25 (4) ◽  
pp. 1465-1470 ◽  
Author(s):  
Daniel Ken Inaoka ◽  
Maiko Iida ◽  
Satoshi Hashimoto ◽  
Toshiyuki Tabuchi ◽  
Takefumi Kuranaga ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Dihydroorotate Dehydrogenase ◽  
Design And Synthesis
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