Synthesis and characterization of valproic acid ester pro-drug micelles via an amphiphilic polycaprolactone block copolymer design

2015 ◽  
Vol 6 (13) ◽  
pp. 2386-2389 ◽  
Author(s):  
Suchithra A. Senevirathne ◽  
Suthida Boonsith ◽  
David Oupicky ◽  
Michael C. Biewer ◽  
Mihaela C. Stefan

The attachment of Histone deacetylase (HDAC) inhibitors via covalent bonds to biocompatible and biodegradable block copolymers provides a new research direction for cancer treatment.


2013 ◽  
Vol 13 (1) ◽  
pp. 81-88 ◽  
Author(s):  
Rajesh Pandit ◽  
Albrecht Berkessel ◽  
Ralf Lach ◽  
Wolfgang Grellmann ◽  
Rameshwar Adhikari

Polystyrene–polybutadiene block copolymers having different molecular architectures were epoxidized by using meta-chloroperoxybenzoic acid (MCPBA). Then, the blends with epoxy resin (diglycidyl ether of bisphenol-A; DGEBA) and their nanocomposites with boehmite and layered silicate nanofiller in presence of methylene dianiline (MDA) as a hardener were prepared. The epoxidized copolymers and the composites were characterized by Fourier transform infrared (FTIR) spectroscopy and microindentation technique. In this way, it was possible to tune the morphology of the nanostructured blends of the epoxy resin using the functionalized block copolymer as the template. The presence of nanostructured morphology was attested by the optical transparency of the blends as well as of the composites with nanofiller. The microhardness properties were improved by the incorporation of the nanoparticles, viz. boehmite and layered silicate. Nepal Journal of Science and Technology Vol. 13, No. 1 (2012) 81-88 DOI: http://dx.doi.org/10.3126/njst.v13i1.7445



1986 ◽  
Vol 31 (1) ◽  
pp. 55-63 ◽  
Author(s):  
Subhas C. Shit ◽  
Beni Madhab Mahato ◽  
Mrinal M. Maiti ◽  
Sukumar Maiti


2015 ◽  
Vol 48 (24) ◽  
pp. 8806-8822 ◽  
Author(s):  
Lian R. Hutchings ◽  
Serena Agostini ◽  
Ian W. Hamley ◽  
Daniel Hermida-Merino


Polymer ◽  
1987 ◽  
Vol 28 (11) ◽  
pp. 1977-1981 ◽  
Author(s):  
J.R.M. Giles ◽  
F.M. Gray ◽  
J.R. MacCallum ◽  
C.A. Vincent


2008 ◽  
Vol 492 (1) ◽  
pp. 172/[536]-183/[547] ◽  
Author(s):  
Young Koo Kwon ◽  
Young Jun Kim


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